Výsledky vyhledávání - "James A Beswick"

Akademický článek

Squaramides enhance NLRP3 inflammasome activation by lowering intracellular potassium

Autor: Paula I. Seoane, James A. Beswick, Andrew G. Leach, Tessa Swanton, Lucy V. Morris, Kevin Couper, Martin Lowe, Sally Freeman, David Brough

Publikováno v: Cell Death Discovery, Vol 9, Iss 1, Pp 1-11 (2023)

Abstract The NLRP3 inflammasome is a component of the inflammatory response to infection and injury, orchestrating the maturation and release of the pro-inflammatory cytokines interleukin-1β (IL-1β), IL-18, and triggering pyroptotic cell death. App

Externí odkaz: https://doaj.org/article/38f74ab91955427e865abe6c6a9ba28b

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Selective inhibition of the K+ efflux sensitive NLRP3 pathway by Cl− channel modulation

Autor: Stephane de Cesco, Daniel Williams, Lucy V Morris, Lina Y El-Sharkawy, Tessa Swanton, Halah Hammadi, Catherine B. Lawrence, Jack Peter Green, David Brough, Shi Yu, Sally Freeman, James A Beswick, John B. Davis

Publikováno v: Swanton, T, Beswick, J, Hammadi, H, Morris, L, Williams, D, De Cesco, S, El-sharkawy, L, Yu, S, Green, J, Davis, J, Lawrence, C, Brough, D & Freeman, S 2020, ' Selective inhibition of the K+ efflux sensitive NLRP3 pathway by Cl-channel modulation ', Chemical Science, vol. 11, no. 43, pp. 11720-11728 . https://doi.org/10.1039/D0SC03828H
Chemical Science

The NLRP3 inflammasome regulates production of the pro-inflammatory cytokines interleukin-1β (IL-1β) and IL-18, and contributes to inflammation exacerbating disease. Fenamate non-steroidal anti-inflammatory drugs (NSAIDs) were recently described as

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d3a8b9179397a434db4dd5074272628
https://doi.org/10.1039/d0sc03828h

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Is Targeting the Inflammasome a Way Forward for Neuroscience Drug Discovery?

Autor: Sally Freeman, James A Beswick, David Brough, Tessa Swanton, James Cook, Catherine B. Lawrence

Publikováno v: Swanton, T, Cook, J, Beswick, J, Freeman, S, Lawrence, C B & Brough, D 2018, ' Is targeting the inflammasome a way forward for neuroscience drug discovery? ', SLAS Discovery . https://doi.org/10.1177/2472555218786210

Neuroinflammation is becoming increasingly recognized as a critical factor in the pathology of both acute and chronic neurological conditions. Inflammasomes such as the one formed by NACHT, LRR, and PYD domains containing protein 3 (NLRP3) are key re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bbf2c42d40ead616f255c9148ac7116
https://doi.org/10.1177/2472555218786210

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LRRC8A is essential for hypotonicity-, but not for DAMP-induced NLRP3 inflammasome activation

Autor: Antony Adamson, Tessa Swanton, Catherine B. Lawrence, Shi Yu, Richard A. Bryce, Sally Freeman, David Brough, Lina Y El-Sharkawy, Jack Peter Green, Lucy V Morris, James Cook, James A Beswick, Neil E. Humphreys

Publikováno v: eLife
eLife, Vol 9 (2020)
Green, J, Swanton, T, Morris, L, El-Sharkawy, L, Cook, J, Yu Shi, A, Beswick, J, Adamson, A, Humphreys, N, Bryce, R, Freeman, S, Lawrence, C B & Brough, D 2020, ' LRRC8A is essential for hypotonicity-, but not for DAMP-induced NLRP3 inflammasome activation ', eLife, vol. 2020, no. 9, e59704 . https://doi.org/10.7554/eLife.59704

The NLRP3 inflammasome is a multi-molecular protein complex that converts inactive cytokine precursors into active forms of IL-1β and IL-18. The NLRP3 inflammasome is frequently associated with the damaging inflammation of non-communicable disease s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a230cebaafbd78209469337b11d79a9
https://doi.org/10.7554/elife.59704

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