Zobrazeno 1 - 10
of 99
pro vyhledávání: '"James A, Roper"'
Autor:
Henry Kim, Louis Kretz, Céline Ronin, Christina Starck, James A. Roper, Barbro Kahl-Knutson, Kristoffer Peterson, Hakon Leffler, Ulf J. Nilsson, Anders Pedersen, Fredrik R. Zetterberg, Robert J. Slack
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 12, p 6704 (2024)
The beta-galactoside-binding mammalian lectin galectin-1 can bind, via its carbohydrate recognition domain (CRD), to various cell surface glycoproteins and has been implicated in a range of cancers. As a consequence of binding to sugar residues on ce
Externí odkaz:
https://doaj.org/article/401dc04e96c343c9aa7b54b26cf21dd8
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 12, p 6756 (2024)
Galectins are a family of beta-galactoside-binding proteins that are characterised by their carbohydrate recognition domain (CRD) and include galectin-1 and galectin-3. These galectins have been implicated in numerous diseases due to their pleiotropi
Externí odkaz:
https://doaj.org/article/1340e77a7f8b44028929455de3d1de9a
Autor:
Joseph Mabbitt, Ian D. Holyer, James A. Roper, Ulf J. Nilsson, Fredrik R. Zetterberg, Lynda Vuong, Alison C. Mackinnon, Anders Pedersen, Robert J. Slack
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
BackgroundGalectin-3 (Gal-3) is a β-galactoside-binding lectin that is highly expressed within the tumor microenvironment of aggressive cancers and has been suggested to predict a poor response to immune checkpoint therapy with the anti-PD-1 monoclo
Externí odkaz:
https://doaj.org/article/83c29c8c1ad94a898306e72ffb5e9687
Autor:
Alison E. John, Rebecca H. Graves, K. Tao Pun, Giovanni Vitulli, Ellen J. Forty, Paul F. Mercer, Josie L. Morrell, John W. Barrett, Rebecca F. Rogers, Maryam Hafeji, Lloyd I. Bibby, Elaine Gower, Valerie S. Morrison, Yim Man, James A. Roper, Jeni C. Luckett, Lee A. Borthwick, Ben S. Barksby, Rachel A. Burgoyne, Rory Barnes, Joelle Le, David J. Flint, Susan Pyne, Anthony Habgood, Louise A. Organ, Chitra Joseph, Rochelle C. Edwards-Pritchard, Toby M. Maher, Andrew J. Fisher, Natasja Stæhr Gudmann, Diana J. Leeming, Rachel C. Chambers, Pauline T. Lukey, Richard P. Marshall, Simon J. F. Macdonald, R. Gisli Jenkins, Robert J. Slack
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
The αvβ6 integrin is key in activating the pro-fibrotic cytokine TGFβ in idiopathic pulmonary fibrosis. Here, the authors show an inhaled small molecule αvβ6 inhibitor GSK3008348 induces prolonged inhibition of TGFβ signaling pathways in human
Externí odkaz:
https://doaj.org/article/0b6e5916f4cb4d2e9b4186f07f1b86ee
Publikováno v:
Austral Ecology. 48:121-133
Autor:
Lucas R.P. Gomes, Alejandro Restrepo González, Claudio J.B. de Carvalho, Márcia S. Couri, João M. Fogaça, James J. Roper
Publikováno v:
Zoologischer Anzeiger. 298:29-38
Publikováno v:
PeerJ, Vol 6, p e5898 (2018)
Food limitation may interact with nest predation and influence nesting patterns, such as breeding season length and renesting intervals. If so, reproductive effort should change with food availability. Thus, when food is limited, birds should have fe
Externí odkaz:
https://doaj.org/article/a752aeaf10164de19b518396f02865bc
Publikováno v:
Nature Reviews. Drug Discovery
Integrins are cell adhesion and signalling proteins crucial to a wide range of biological functions. Effective marketed treatments have successfully targeted integrins αIIbβ3, α4β7/α4β1 and αLβ2 for cardiovascular diseases, inflammatory bowel
Autor:
Marcio Mageski, Rodrigo B. Ferreira, Paulo R. Jesus, Larissa C. da Costa, James J. Roper, Paulo D. Ferreira
Publikováno v:
Zoologia (Curitiba), Vol 32, Iss 5, Pp 329-333 (2015)
ABSTRACT The island rule suggests that, when mainland animals are isolated on islands, large animals tend to become smaller, while small animals tend to become larger. A small frog in eastern Brazil, Phyllodytes luteolus (Wied-Neuwied, 1824), is wide
Externí odkaz:
https://doaj.org/article/cde7af73cead46459a2fc06018e2588d
Autor:
Fredrik R. Zetterberg, Alison MacKinnon, Thomas Brimert, Lise Gravelle, Richard E. Johnsson, Barbro Kahl-Knutson, Hakon Leffler, Ulf J. Nilsson, Anders Pedersen, Kristoffer Peterson, James A. Roper, Hans Schambye, Robert J. Slack, Susan Tantawi
Publikováno v:
Journal of medicinal chemistry. 65(19)
Galectin-3 is a carbohydrate-binding protein central to regulating mechanisms of diseases such as fibrosis, cancer, metabolic, inflammatory, and heart disease. We recently found a high affinity (nM) thiodigalactoside GB0139 which currently is in clin