Targeting Artificial Tumor Stromal Targets for Molecular Imaging of Tumor Vascular Hypoxia.

Autor: Nathan A Koonce, Joseph Levy, Matthew E Hardee, Azemat Jamshidi-Parsian, Kieng B Vang, Sunil Sharma, James A Raleigh, Ruud P M Dings, Robert J Griffin

Publikováno v: PLoS ONE, Vol 10, Iss 8, p e0135607 (2015)

Developed and tested for many years, a variety of tumor hypoxia detection methods have been inconsistent in their ability to predict treatment outcomes or monitor treatment efficacy, limiting their present prognostic capability. These variable result

Externí odkaz: https://doaj.org/article/6f48f27312984dc09266f175dcd34772

Reproducibility of peak oxygen consumption and the impact of test variability on classification of individual training responses in young recreationally active adults

Autor: Matthew D. Giles, Mario P. Rotundo, Brendon J. Gurd, Brittany A. Edgett, Jacob T. Bonafiglia, Jonathan P. Whittall, James P. Raleigh

Publikováno v: Clinical Physiology and Functional Imaging. 38:630-638

This study investigated whether VO2 peak is reproducible across repeated tests before (PRE) and after (POST) training, and whether variability across tests impacts how individual responses are classified following 3 weeks of aerobic exercise training

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f36b6997162110020941e907ad19e0b
https://doi.org/10.1111/cpf.12459

The impact of a 48-h fast on SIRT1 and GCN5 in human skeletal muscle

Autor: Craig A. Simpson, Brittany A. Edgett, Joe Quadrilatero, Kristen Boonstra, Brendon J. Gurd, James P. Raleigh, Christopher G. R. Perry, Trisha D. Scribbans, Jennifer B. L. Matusiak

Publikováno v: Applied Physiology, Nutrition, and Metabolism. 41:953-962

The present study examined the impact of a 48 h fast on the expression and activation status of SIRT1 and GCN5, the relationship between SIRT1/GCN5 and the gene expression of PGC-1α, and the PGC-1α target PDK4 in the skeletal muscle of 10 lean heal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd5e81f13fa8f74f3881122383d515be
https://doi.org/10.1139/apnm-2016-0130

PET imaging of tumor hypoxia using18F-labeled pimonidazole

Autor: Steen Jakobsen, Jens Overgaard, Michael R. Horsman, Lise SakesØ Mortensen, Xiaosheng Ji, James R. Raleigh, Marianne Nordsmark, Morten Busk, David Y.W. Lee, Ane B. Iversen

Publikováno v: Acta Oncologica
Busk, M, Jakobsen, S, Horsman, M R, Mortensen, L S, Iversen, A B, Overgaard, J, Nordsmark, M, Ji, X, Lee, D Y & Raleigh, J R 2013, ' PET imaging of tumor hypoxia using 18 F-labeled pimonidazole ', Acta Oncologica, vol. 52, no. 7, pp. 1300-1307 . https://doi.org/10.3109/0284186X.2013.815797
Acta Oncologica; Vol 52

Background. Tumor hypoxia contributes to loco-regional failure, and for optimal treatment planning, knowledge about tumor hypoxia in individual patients is required. Nitroimidazole-based tracers, which are retained in hypoxic cells, allow PET-based a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::204f70b909eb75a10f69f01c552e1aa5

Endogenous Myoglobin in Breast Cancer Is Hypoxia-inducible by Alternative Transcription and Functions to Impair Mitochondrial Activity

Autor: James A. Raleigh, Mahesh A. Varia, Josefine Gerhardt, Eva Gleixner, Daniel P. Stiehl, Patrick Subarsky, Francesca M. Scandurra, Max Gassmann, Michael Rose, Annette Bohnert, Annette Ten Haaf, Daniela Wichmann, Glen Kristiansen, Thomas Hankeln, Junmin Hu, Holger Moch, Thomas A. Gorr, Erich Gnaiger, Edgar Dahl, Anne Bicker

Publikováno v: Journal of Biological Chemistry. 286:43417-43428

Recently, immunohistochemical analysis of myoglobin (MB) in human breast cancer specimens has revealed a surprisingly widespread expression of MB in this nonmuscle context. The positive correlation with hypoxia-inducible factor 2α (HIF-2α) and carb

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8afcc98c9cdb972f30f7e7613cbd304b
https://doi.org/10.1074/jbc.m111.227553