Zobrazeno 1 - 10
of 597
pro vyhledávání: '"James A, Pearson"'
Autor:
Pai Wang, Xin Yang, Luyao Zhang, Sha Sha, Juan Huang, Jian Peng, Jianlei Gu, James Alexander Pearson, Youjia Hu, Hongyu Zhao, F. Susan Wong, Quan Wang, Li Wen
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Toll-like receptor 9 (TLR9) recognizes bacterial, viral and self DNA and play an important role in immunity and inflammation. However, the role of TLR9 in obesity is less well-studied. Here, we generate B-cell-specific Tlr9-deficient (Tlr9 f
Externí odkaz:
https://doaj.org/article/ddc6b00a11fc457385775e297ca7f58c
Autor:
Mark T. Waddingham, Hirotsugu Tsuchimochi, Takashi Sonobe, Vasco Sequeira, Md Junayed Nayeem, Mikiyasu Shirai, James T. Pearson, Takeshi Ogo
Publikováno v:
Journal of Molecular and Cellular Cardiology Plus, Vol 8, Iss , Pp 100072- (2024)
Background: Pulmonary hypertension (PH) often leads to right ventricle (RV) failure, a significant cause of morbidity and mortality. Despite advancements in PH management, progression to RV maladaptation and subsequent failure remain a clinical chall
Externí odkaz:
https://doaj.org/article/c799fd064dab4b7da859a49b8d77c099
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionThe incidence of the autoimmune disease, type 1 diabetes (T1D), has been increasing worldwide and recent studies have shown that the gut microbiota are associated with modulating susceptibility to T1D. Toll-like receptor 5 (TLR5) recogniz
Externí odkaz:
https://doaj.org/article/f49d25e268f04923a01b31f47da686c0
Autor:
Kaye N. Ballantyne, Stephanie Summersby, James R. Pearson, Katherine Nicol, Erin Pirie, Catherine Quinn, Rebecca Kogios
Publikováno v:
Forensic Science International: Synergy, Vol 8, Iss , Pp 100474- (2024)
There have been numerous calls for increased transparency and disclosure in forensic science. However, there is a paucity of guidance on how to achieve this transparency in reports, and the impacts it may have on criminal justice proceedings. We desc
Externí odkaz:
https://doaj.org/article/032e5310b2424d34baeda1f0a619b496
Publikováno v:
Journal of Molecular and Cellular Cardiology Plus, Vol 4, Iss , Pp 100036- (2023)
Hypertrophic cardiomyopathy (HCM) is a frequent inherited form of heart failure. The underlying cause of HCM is generally attributed to mutations in genes that encode for sarcomeric proteins, but the pathogenesis of the disease is also influenced by
Externí odkaz:
https://doaj.org/article/d22b4f365c34488b9d7765bb109279d5
Publikováno v:
Frontiers in Physiology, Vol 14 (2023)
Externí odkaz:
https://doaj.org/article/bd72aeacb50d40ec9615b80733eb17e8
Autor:
James A. Pearson, Jian Peng, Juan Huang, Xiaoqing Yu, Ningwen Tai, Youjia Hu, Sha Sha, Richard A. Flavell, Hongyu Zhao, F. Susan Wong, Li Wen
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionGut microbiota have been linked to modulating susceptibility to Type 1 diabetes; however, there are many ways in which the microbiota interact with host cells, including through microbial ligand binding to intracellular inflammasomes (lar
Externí odkaz:
https://doaj.org/article/e81605a24c0f43b481c0a75c772edb75
Publikováno v:
Frontiers in Endocrinology, Vol 13 (2022)
Type 2 diabetes mellitus, obesity and metabolic syndrome are becoming more prevalent worldwide and will present an increasingly challenging burden on healthcare systems. These interlinked metabolic abnormalities predispose affected individuals to a p
Externí odkaz:
https://doaj.org/article/ae4fd85be4244628a6dbe6afec0fa509
Autor:
Eng Leng Saw, James T. Pearson, Daryl O. Schwenke, Pujika Emani Munasinghe, Hirotsugu Tsuchimochi, Shruti Rawal, Sean Coffey, Philip Davis, Richard Bunton, Isabelle Van Hout, Yuko Kai, Michael J. A. Williams, Yoshihiko Kakinuma, Martin Fronius, Rajesh Katare
Publikováno v:
Cardiovascular Diabetology, Vol 20, Iss 1, Pp 1-16 (2021)
Abstract Background Acetylcholine (ACh) plays a crucial role in the function of the heart. Recent evidence suggests that cardiomyocytes possess a non-neuronal cholinergic system (NNCS) that comprises of choline acetyltransferase (ChAT), choline trans
Externí odkaz:
https://doaj.org/article/a7945995bbd64248a9c867a8dfe3eb4d
Publikováno v:
Ecosphere, Vol 13, Iss 5, Pp n/a-n/a (2022)
Abstract Climate change can act to facilitate or inhibit invasions of non‐native species. Here, we address the influence of climate change on control of non‐native common carp (hereafter, carp), a species recognized as one of the “world's worst
Externí odkaz:
https://doaj.org/article/233b9989a80c40a49b3ae87d7851c391