Zobrazeno 1 - 10
of 40
pro vyhledávání: '"James A, Nieman"'
Autor:
Elena Arutyunova, Alexandr Belovodskiy, Pu Chen, Muhammad Bashir Khan, Michael Joyce, Holly Saffran, Jimmy Lu, Zoe Turner, Bing Bai, Tess Lamer, Howard S. Young, John C. Vederas, D. Lorne Tyrrell, M. Joanne Lemieux, James A. Nieman
Publikováno v:
ACS Bio & Med Chem Au, Vol 3, Iss 6, Pp 528-541 (2023)
Externí odkaz:
https://doaj.org/article/b8e37dea5f004761a5ac48cc97ba66e2
Autor:
Sizhu Amelia Chen, Elena Arutyunova, Jimmy Lu, Muhammad Bashir Khan, Wioletta Rut, Mikolaj Zmudzinski, Shima Shahbaz, Jegan Iyyathurai, Eman W. Moussa, Zoe Turner, Bing Bai, Tess Lamer, James A. Nieman, John C. Vederas, Olivier Julien, Marcin Drag, Shokrollah Elahi, Howard S. Young, M. Joanne Lemieux
Publikováno v:
ACS Central Science. 9:696-708
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::06bc781507dacd5fb23130306731addf
https://doi.org/10.1021/acscentsci.3c00054
https://doi.org/10.1021/acscentsci.3c00054
Autor:
Sizhu Amelia Chen, Elena Arutyunova, Jimmy Lu, Muhammad Bashir Khan, Wioletta Rut, Mikolaj Zmudzinski, Shima Shahbaz, Jegan Iyyathurai, Eman Moussa, Zoe Turner, Bing Bai, Tess Lamer, James A. Nieman, John C. Vederas, Olivier Julien, Marcin Drag, Shokrollah Elahi, Howard S. Young, M. Joanne Lemieux
Main protease of SARS-CoV-2 (Mpro) is the most promising drug target against coronaviruses due to its essential role in virus replication. With newly emerging variants there is a concern that mutations in Mpromay alter structural and functional prope
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0ee9208612c8234925406e453eff6a5a
https://doi.org/10.1101/2023.01.28.525917
https://doi.org/10.1101/2023.01.28.525917
Autor:
Appan Srinivas Kandadai, Bing Bai, Mohammad Rahim, Fusen Lin, Zhengxian Gu, Xinyi Qi, Xuecheng Zhang, Haiheng Dong, Ying Chen, John Shen, James A. Nieman
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1f619abf91740763cf5762591a1d7d98
https://doi.org/10.2139/ssrn.4352003
https://doi.org/10.2139/ssrn.4352003
Autor:
Muhammad Bashir Khan, Jimmy Lu, Elena Arutyunova, John C. Vederas, James A. Nieman, Howard S. Young, Mohammad Rahim, Yanhua Du, Wayne Vuong, M. Joanne Lemieux, Marco J. van Belkum, Holly A. Saffran, Conrad Fischer, Bing Bai, Alexandr Belovodskiy, Michael A. Joyce, Fusen Lin, Jia Xu, Hena Mostafa, Justin Shields, Darren Hockman, Tess Lamer, D. Lorne Tyrrell, Appan Srinivas Kandadai, Sardeev K Bajwa, Zhengxian Gu
Publikováno v:
Journal of Medicinal Chemistry. 65:2905-2925
Recurring coronavirus outbreaks, such as the current COVID-19 pandemic, establish a necessity to develop direct-acting antivirals that can be readily administered and are active against a broad spectrum of coronaviruses. Described in this Article are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::134b04d6422ffafa8fa4be69bcd0a43a
https://doi.org/10.1021/acs.jmedchem.1c00616
https://doi.org/10.1021/acs.jmedchem.1c00616
Autor:
Appan Srinivas Kandadai, Bing Bai, Mohammad Rahim, Fusen Lin, Zhengxian Gu, Xinyi Qi, Xuecheng Zhang, Haiheng Dong, Ying Chen, John Shen, James A. Nieman
Publikováno v:
Bioorganic & Medicinal Chemistry. 85:117276
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f62652040132f8baa9879c7d1f449a62
https://doi.org/10.1016/j.bmc.2023.117276
https://doi.org/10.1016/j.bmc.2023.117276
Autor:
Howard S. Young, Muhammad Bashir Khan, Hena Mostafa, Tess Lamer, Alexandr Belovodskiy, Justin Shields, Wayne Vuong, Holly A. Saffran, Michael A. Joyce, Elena Arutyunova, Jimmy Lu, James A. Nieman, D. Lorne Tyrrell, Appan Srinivas Kandadai, Bing Bai, John C. Vederas, M. Joanne Lemieux
Publikováno v:
RSC Med Chem
Tragically, the death toll from the COVID-19 pandemic continues to rise, and with variants being observed around the globe new therapeutics, particularly direct-acting antivirals that are easily administered, are desperately needed. Studies targeting
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bcc67e136d0b12f76b4688d739f493ae
https://doi.org/10.1039/d1md00247c
https://doi.org/10.1039/d1md00247c
Autor:
Holly Freedman, Matthias Götte, Michael Houghton, D. Lorne Tyrrell, James A. Nieman, John Lok Man Law, Egor P. Tchesnokov, Raymond F. Schinazi, Juthika Kundu
Publikováno v:
J Chem Inf Model
The RNA-dependent RNA polymerase (RdRp) of norovirus is an attractive target of antiviral agents aimed at providing protection against norovirusassociated gastroenteritis. Here, we perform molecular dynamics simulations of the crystal structure of no
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46730a0955cc68f920f6989a27d93d1c
https://doi.org/10.1021/acs.jcim.0c00742
https://doi.org/10.1021/acs.jcim.0c00742
Autor:
Bing, Bai, Alexandr, Belovodskiy, Mostofa, Hena, Appan Srinivas, Kandadai, Michael A, Joyce, Holly A, Saffran, Justin A, Shields, Muhammad Bashir, Khan, Elena, Arutyunova, Jimmy, Lu, Sardeev K, Bajwa, Darren, Hockman, Conrad, Fischer, Tess, Lamer, Wayne, Vuong, Marco J, van Belkum, Zhengxian, Gu, Fusen, Lin, Yanhua, Du, Jia, Xu, Mohammad, Rahim, Howard S, Young, John C, Vederas, D Lorne, Tyrrell, M Joanne, Lemieux, James A, Nieman
Publikováno v:
Journal of Medicinal Chemistry
Recurring coronavirus outbreaks, such as the current COVID-19 pandemic, establish a necessity to develop direct-acting antivirals that can be readily administered and are active against a broad spectrum of coronaviruses. Described in this Article are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1ba0e09460619e979a4ea92d8978fe08
https://pubmed.ncbi.nlm.nih.gov/34242027
https://pubmed.ncbi.nlm.nih.gov/34242027
Autor:
Robert L. Hoffman, Robert S. Kania, Mary A. Brothers, Jay F. Davies, Rose A. Ferre, Ketan S. Gajiwala, Mingying He, Robert J. Hogan, Kirk Kozminski, Lilian Y. Li, Jonathan W. Lockner, Jihong Lou, Michelle T. Marra, Lennert J. Mitchell, Brion W. Murray, James A. Nieman, Stephen Noell, Simon P. Planken, Thomas Rowe, Kevin Ryan, George J. Smith, James E. Solowiej, Claire M. Steppan, Barbara Taggart
Publikováno v:
Journal of Medicinal Chemistry
The novel coronavirus disease COVID-19 that emerged in 2019 is caused by the virus SARS CoV-2 and named for its close genetic similarity to SARS CoV-1 that caused severe acute respiratory syndrome (SARS) in 2002. Both SARS coronavirus genomes encode
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c849279282022a7854304d328352c0f1