Zobrazeno 1 - 10
of 183
pro vyhledávání: '"James A, Mobley"'
Autor:
Harper S. Kim, Danitra J. Parker, Madison M. Hardiman, Erin Munkácsy, Nisi Jiang, Aric N. Rogers, Yidong Bai, Colin Brent, James A. Mobley, Steven N. Austad, Andrew M. Pickering
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract Protein translation (PT) declines with age in invertebrates, rodents, and humans. It has been assumed that elevated PT at young ages is beneficial to health and PT ends up dropping as a passive byproduct of aging. In Drosophila, we show that
Externí odkaz:
https://doaj.org/article/9b7c7453c2704f3090c9123524769e52
Publikováno v:
Frontiers in Endocrinology, Vol 14 (2023)
IntroductionAs a metabolic disease, diabetes often leads to health complications such as heart failure, nephropathy, neurological disorders, and vision loss. Diabetic retinopathy (DR) affects as many as 100 million people worldwide. The mechanism of
Externí odkaz:
https://doaj.org/article/f9c80f38e04b40e49094e9577abbe92a
Autor:
Erin Y. Earnhardt, Jennifer L. Tipper, Adonis D’Mello, Ming-Yuan Jian, Elijah S. Conway, James A. Mobley, Carlos J. Orihuela, Hervé Tettelin, Kevin S. Harrod
Publikováno v:
JCI Insight, Vol 8, Iss 14 (2023)
Influenza A virus (IAV) infection is commonly complicated by secondary bacterial infections that lead to increased morbidity and mortality. Our recent work demonstrates that IAV disrupts airway homeostasis, leading to airway pathophysiology resemblin
Externí odkaz:
https://doaj.org/article/7e87c160e938464ba226cadb630cb6cf
Autor:
Ava C. Wilson, Joe Chiles, Shah Ashish, Diptiman Chanda, Preeti L. Kumar, James A. Mobley, Enid R. Neptune, Victor J. Thannickal, Merry-Lynn N. McDonald
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-9 (2022)
Abstract Fibrosis is a leading cause of morbidity and mortality worldwide. Although fibrosis may involve different organ systems, transforming growth factor-β (TGFβ) has been established as a master regulator of fibrosis across organs. Pirfenidone
Externí odkaz:
https://doaj.org/article/9701304c485e469590dc260ebd8077b2
Autor:
Qiang-Qiang Xia, Angela K Walker, Chenghui Song, Jing Wang, Anju Singh, James A Mobley, Zhong X Xuan, Jeffrey D Singer, Craig M Powell
Publikováno v:
PLoS ONE, Vol 18, Iss 7, p e0283299 (2023)
Autism Spectrum Disorder (ASD) is a developmental disorder in which children display repetitive behavior, restricted range of interests, and atypical social interaction and communication. CUL3, coding for a Cullin family scaffold protein mediating as
Externí odkaz:
https://doaj.org/article/3822b5b797b9457ab8bef3f0813fc6a5
Autor:
Sajina GC, Kaysaw Tuy, Lucas Rickenbacker, Robert Jones, Asmi Chakraborty, C. Ryan Miller, Elizabeth A. Beierle, Vidya Sagar Hanumanthu, Anh N. Tran, James A. Mobley, Susan L. Bellis, Anita B. Hjelmeland
Publikováno v:
JCI Insight, Vol 7, Iss 21 (2022)
One of the least-investigated areas of brain pathology research is glycosylation, which is a critical regulator of cell surface protein structure and function. β-Galactoside α2,6-sialyltransferase (ST6GAL1) is the primary enzyme that α2,6 sialylat
Externí odkaz:
https://doaj.org/article/cf92d181c1a04f8787c7b10cecb716a3
Autor:
Brandon M. Roberts, Sarah E. Deemer, Daniel L. Smith, James A. Mobley, Nicolas Musi, Eric P. Plaisance
Publikováno v:
Frontiers in Nutrition, Vol 9 (2022)
Exogenous ketone ester supplementation provides a means to increase circulating ketone concentrations without the dietary challenges imposed by ketogenic diets. Our group has shown that oral R,S-1,3, butanediol diacetoacetate (BD-AcAc2) consumption r
Externí odkaz:
https://doaj.org/article/afdb28195c564855a4841bea8ca54b17
Autor:
Shannon E. Weeks, Sarah C. Kammerud, Brandon J. Metge, Heba A. AlSheikh, David A. Schneider, Dongquan Chen, Shi Wei, James A. Mobley, Akinyemi I. Ojesina, Lalita A. Shevde, Rajeev S. Samant
Publikováno v:
Cell Death and Disease, Vol 12, Iss 3, Pp 1-13 (2021)
Abstract Triple-negative breast cancer (TNBC) patients with upregulated Wnt/β-catenin signaling often have poor clinical prognoses. During pathological examinations of breast cancer sections stained for β-catenin, we made the serendipitous observat
Externí odkaz:
https://doaj.org/article/9501db756b5244c1bd2c083ff6d813b3
Autor:
Lin Jin, Yunjia Chen, David K. Crossman, Arunima Datta, Trung Vu, James A. Mobley, Malay Kumar Basu, Mariangela Scarduzio, Hengbin Wang, Chenbei Chang, Pran K. Datta
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
STRAP (serine threonine kinase receptor-associated protein) promotes tumorigenicity. Here the authors report that STRAP associates with spliceosome and regulates alternative splicing during embryonic stem cell lineage commitment and early mouse embry
Externí odkaz:
https://doaj.org/article/384c3fe5ae0a46a19a739286b1d0d257
Autor:
Ahmed Asfari, MD, Kristal M. Hock, MSN, RN, CNL, Jonathan W. Byrnes, MD, Santiago Borasino, MD, MPH, Brian A. Halloran, MD, James A. Mobley, MD, Namasivayam Ambalavanan, MD
Publikováno v:
Critical Care Explorations, Vol 3, Iss 9, p e0528 (2021)
OBJECTIVES:. Cardiopulmonary bypass triggers systemic inflammation, resulting in lung injury, and frequently leads to prolonged mechanical ventilation. Biomarkers of systemic inflammation are required to predict the risk of such complications. We hyp
Externí odkaz:
https://doaj.org/article/8456b93c2a3c46d19727f462cd2c342e