Zobrazeno 1 - 10
of 255
pro vyhledávání: '"James A, DeCaprio"'
Autor:
Rajarshi Choudhury, Thomas Bonacci, Anthony Arceci, Debojyoti Lahiri, Christine A. Mills, Jennifer L. Kernan, Timothy B. Branigan, James A. DeCaprio, Daniel J. Burke, Michael J. Emanuele
Publikováno v:
Cell Reports, Vol 43, Iss 3, Pp 113974- (2024)
Externí odkaz:
https://doaj.org/article/e9392c2bf406451da92c8591228d6143
Autor:
Thomas C. Frost, Ashley K. Gartin, Mofei Liu, Jingwei Cheng, Harita Dharaneeswaran, Derin B. Keskin, Catherine J. Wu, Anita Giobbie-Hurder, Manisha Thakuria, James A. DeCaprio
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 5 (2023)
Background Merkel cell carcinoma (MCC) is an aggressive neuroendocrine (NE) skin cancer caused by severe UV-induced mutations or expression of Merkel cell polyomavirus (MCPyV) large and small T antigens (LT and ST). Despite deep genetic differences b
Externí odkaz:
https://doaj.org/article/31f00fa0795e4d19a0af10a923b14cf7
Autor:
Ruchi Kumari, Holger Hummerich, Xu Shen, Martin Fischer, Larisa Litovchick, Sibylle Mittnacht, James A. DeCaprio, Parmjit S. Jat
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract Cellular senescence is a stable cell cycle arrest that normal cells undergo after a finite number of divisions, in response to a variety of intrinsic and extrinsic stimuli. Although senescence is largely established and maintained by the p53
Externí odkaz:
https://doaj.org/article/6e66597928294524a625be5f57918552
Autor:
Todd C. Knepper, Robyn A. Panchaud, Elnara Muradova, Leah Cohen, James A. DeCaprio, Nikhil I. Khushalani, Kenneth Y. Tsai, Andrew S. Brohl
Publikováno v:
Cancer Medicine, Vol 10, Iss 17, Pp 5889-5896 (2021)
Abstract Background The use of targeted therapy remains a treatment consideration for some patients with advanced Merkel cell carcinoma (MCC). However, supportive data on the use of targeted therapy approaches are limited. Thus, we sought to evaluate
Externí odkaz:
https://doaj.org/article/03143699f2cc4cb1b346c3d03f6e54ed
Autor:
Peng Wang, Esra Karakose, Carmen Argmann, Huan Wang, Metodi Balev, Rachel I. Brody, Hembly G. Rivas, Xinyue Liu, Olivia Wood, Hongtao Liu, Lauryn Choleva, Dan Hasson, Emily Bernstein, Joao A. Paulo, Donald K. Scott, Luca Lambertini, James A. DeCaprio, Andrew F. Stewart
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 15 (2022)
Resistance to regeneration of insulin-producing pancreatic β cells is a fundamental challenge for type 1 and type 2 diabetes. Recently, small molecule inhibitors of the kinase DYRK1A have proven effective in inducing adult human β cells to prolifer
Externí odkaz:
https://doaj.org/article/d63ba477fc65456b990c8a7587bff961
Autor:
Varsha Ananthapadmanabhan, Thomas C. Frost, Kara M. Soroko, Aine Knott, Brianna J. Magliozzi, Prafulla C. Gokhale, Vijaya G. Tirunagaru, Robert C. Doebele, James A. DeCaprio
Publikováno v:
JCI Insight, Vol 7, Iss 13 (2022)
Merkel cell carcinoma (MCC) is an aggressive neuroendocrine carcinoma of the skin with 2 etiologies. Merkel cell polyomavirus (MCPyV) integration is present in about 80% of all MCC. Virus-positive MCC (MCCP) tumors have few somatic mutations and usua
Externí odkaz:
https://doaj.org/article/48d1999c6108493896009222e6cd2895
Autor:
Patrick C. Lee, Susan Klaeger, Phuong M. Le, Keegan Korthauer, Jingwei Cheng, Varsha Ananthapadmanabhan, Thomas C. Frost, Jonathan D. Stevens, Alan Y.L. Wong, J. Bryan Iorgulescu, Anna Y. Tarren, Vipheaviny A. Chea, Isabel P. Carulli, Camilla K. Lemvigh, Christina B. Pedersen, Ashley K. Gartin, Siranush Sarkizova, Kyle T. Wright, Letitia W. Li, Jason Nomburg, Shuqiang Li, Teddy Huang, Xiaoxi Liu, Lucas Pomerance, Laura M. Doherty, Annie M. Apffel, Luke J. Wallace, Suzanna Rachimi, Kristen D. Felt, Jacquelyn O. Wolff, Elizabeth Witten, Wandi Zhang, Donna Neuberg, William J. Lane, Guanglan Zhang, Lars R. Olsen, Manisha Thakuria, Scott J. Rodig, Karl R. Clauser, Gabriel J. Starrett, John G. Doench, Sara J. Buhrlage, Steven A. Carr, James A. DeCaprio, Catherine J. Wu, Derin B. Keskin
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 13 (2022)
Cancers avoid immune surveillance through an array of mechanisms, including perturbation of HLA class I antigen presentation. Merkel cell carcinoma (MCC) is an aggressive, HLA-I–low, neuroendocrine carcinoma of the skin often caused by the Merkel c
Externí odkaz:
https://doaj.org/article/60397b52dbf342a38a8b4cfb3371eac6
Autor:
Megan E Spurgeon, Jingwei Cheng, Ella Ward-Shaw, Frederick A Dick, James A DeCaprio, Paul F Lambert
Publikováno v:
PLoS Pathogens, Vol 18, Iss 5, p e1010551 (2022)
Clear evidence supports a causal link between Merkel cell polyomavirus (MCPyV) and the highly aggressive human skin cancer called Merkel cell carcinoma (MCC). Integration of viral DNA into the human genome facilitates continued expression of the MCPy
Externí odkaz:
https://doaj.org/article/20d6ff3165f54718b5c7480b0f8a536c
Publikováno v:
Genome Medicine, Vol 12, Iss 1, Pp 1-14 (2020)
Abstract Background SARS-CoV-2, a positive-sense RNA virus in the family Coronaviridae, has caused a worldwide pandemic of coronavirus disease 2019 or COVID-19. Coronaviruses generate a tiered series of subgenomic RNAs (sgRNAs) through a process invo
Externí odkaz:
https://doaj.org/article/c9f8efce104246e099617568dda9fcdd
Autor:
Jason Nomburg, Wei Zou, Thomas C Frost, Chandreyee Datta, Shobha Vasudevan, Gabriel J Starrett, Michael J Imperiale, Matthew Meyerson, James A DeCaprio
Publikováno v:
PLoS Pathogens, Vol 18, Iss 4, p e1010401 (2022)
Polyomaviruses (PyV) are ubiquitous pathogens that can cause devastating human diseases. Due to the small size of their genomes, PyV utilize complex patterns of RNA splicing to maximize their coding capacity. Despite the importance of PyV to human di
Externí odkaz:
https://doaj.org/article/617256a3a1db4dce84c7251edeb7863b