Zobrazeno 1 - 10
of 125
pro vyhledávání: '"James A, Cardelli"'
Publikováno v:
BMC Cancer, Vol 17, Iss 1, Pp 1-15 (2017)
Abstract Background Tumor invasion through a basement membrane is one of the earliest steps in metastasis, and growth factors, such as Epidermal Growth Factor (EGF) and Hepatocyte Growth Factor (HGF), stimulate this process in a majority of solid tum
Externí odkaz:
https://doaj.org/article/dd6e2247cebd4a56839f6b0e77fbb2b9
Supplementary Fig. S1 from Inhibition of fatty acid synthase by luteolin post-transcriptionally down-regulates c-Met expression independent of proteosomal/lysosomal degradation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47a37a8a62c848ef1497acd2ea95680a
https://doi.org/10.1158/1535-7163.22482606
https://doi.org/10.1158/1535-7163.22482606
Autor:
James A. Cardelli, Briana Jill Williams, Jennifer L. Carroll, Joshua J. Steffan, Rebecca L. Bigelow, David T. Coleman, Patrick Burke, Shawn A. Milligan
Purpose: Activation of the c-Met and epidermal growth factor receptors (EGFR) promotes the growth and survival of non–small cell lung cancer (NSCLC). Specific receptor antagonists have shown efficacy in the clinic, but tumors often become resistant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c58cc1a8a103ab0279df7b69c1d31dff
https://doi.org/10.1158/1078-0432.c.6518730
https://doi.org/10.1158/1078-0432.c.6518730
Publikováno v:
PLoS ONE, Vol 10, Iss 5, p e0125399 (2015)
Curcumin has been shown to mitigate cancer phenotypes such as invasive migration, proliferation, and survival by disrupting numerous signaling pathways. Our previous studies showed that curcumin inhibits integrin β4 (ITG β4)-dependent migration by
Externí odkaz:
https://doaj.org/article/893ee75b3007490f8c15f9d1e82fee8f
Autor:
Joshua J Steffan, Samantha S Dykes, David T Coleman, Lisa K Adams, Donna Rogers, Jennifer L Carroll, B Jill Williams, James A Cardelli
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e87882 (2014)
Invasion and subsequent metastasis is the major cause of death from most cancers including prostate cancer. Herein we report on the potential tumor suppressive properties of Rab7, a GTPase that regulates trafficking of lysosomes. The movement of lyso
Externí odkaz:
https://doaj.org/article/cd2fb7e980874e06bcd990e6a6d377bc
Publikováno v:
PLoS ONE, Vol 9, Iss 10, p e109208 (2014)
The presence of reactive stroma, predominantly composed of myofibroblasts, is directly associated with and drives prostate cancer progression. We have previously shown that (-)-Epigallocatechin-3-gallate (EGCG), in the form of Polyphenon E, significa
Externí odkaz:
https://doaj.org/article/61780c3c6649402aab5a42628ae3358b
Autor:
James A. Cardelli, Ahmed Abu-Fayyad, Ana-Maria Dragoi, Jennifer L. Carroll, Sami Nazzal, Mohammad M. Kamal, Robert Cody
Publikováno v:
International Journal of Pharmaceutics. 536:146-157
Vitamin E TPGS is a tocopherol (α-T) based nonionic surfactant that was used in the formulation of the Tocosol™ paclitaxel nanoemulsion, which was withdrawn from phase III clinical trials. Unlike tocopherols, however, the tocotrienol (T3) isomers
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::133ec85f3a41afd07331353b81b592bd
https://doi.org/10.1016/j.ijpharm.2017.11.062
https://doi.org/10.1016/j.ijpharm.2017.11.062
Autor:
Rebecca L. H. Bigelow, Jason M. Bodily, William K. Songock, James A. Cardelli, Samantha S. Dykes, George F. Vande Woude, Chong-Feng Gao
Publikováno v:
Molecular Carcinogenesis. 56:722-734
Tumor cell invasion through the extracellular matrix is facilitated by the secretion of lysosome-associated proteases. As a common mechanism for secretion, lysosomes must first traffic to the cell periphery (anterograde trafficking), consistent with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::016fa8ada89337b22dbf3121c0cae93b
https://doi.org/10.1002/mc.22528
https://doi.org/10.1002/mc.22528
Autor:
Ana-Maria Dragoi, James A. Cardelli, Belnaser A. Busnena, Mohamed M. Mohyeldin, Khalid A. El Sayed, Mohamed R. Akl
Publikováno v:
European Journal of Medicinal Chemistry. 118:299-315
Dysregulated receptor tyrosine kinase c-Met and its ligand HGF is valid and attractive molecular target for therapeutic blockade in cancer. Inspired by the chemical structure of the naturally occurring olive secoiridoid (-)-oleocanthal (1) and its do
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3aa326838fec1467b44e5f1aa9249ca1
https://doi.org/10.1016/j.ejmech.2016.04.043
https://doi.org/10.1016/j.ejmech.2016.04.043
Autor:
Alana L. Gray, Charles A. Stephens, Samantha S. Dykes, Madhurima Saxena, Kevin Pruitt, James A. Cardelli, Jennifer L. Carroll, David T. Coleman
Publikováno v:
Oncotarget
Cancer is a multistep process that requires cells to respond appropriately to the tumor microenvironment, both in early proliferative stages and in later invasive disease. Arl8b is a lysosome localized Arf-like GTPase that controls the spatial distri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f8bab48f90ab44578847a18ccbfce75
https://doi.org/10.18632/oncotarget.8832
https://doi.org/10.18632/oncotarget.8832