Consistent detection of Trypanosoma brucei but not T. congolense DNA in faeces of experimentally infected cattle

Autor: Isabel Saldanha, Martha Betson, Christina Vrettou, Edith Paxton, James Nixon, Peter Tennant, Adrian Ritchie, Keith R. Matthews, Liam J. Morrison, Stephen J. Torr, Lucas J. Cunningham

Publikováno v: Scientific Reports, Vol 14, Iss 1, Pp 1-15 (2024)

Abstract Animal African trypanosomiasis (AAT) is a significant food security and economic burden in sub-Saharan Africa. Current AAT empirical and immunodiagnostic surveillance tools suffer from poor sensitivity and specificity, with blood sampling re

Externí odkaz: https://doaj.org/article/07898443b1c145f8bea0260d12f3222b

Cross-species efficacy of enzyme replacement therapy for CLN1 disease in mice and sheep

Autor: Hemanth R. Nelvagal, Samantha L. Eaton, Sophie H. Wang, Elizabeth M. Eultgen, Keigo Takahashi, Steven Q. Le, Rachel Nesbitt, Joshua T. Dearborn, Nicholas Siano, Ana C. Puhl, Patricia I. Dickson, Gerard Thompson, Fraser Murdoch, Paul M. Brennan, Mark Gray, Stephen N. Greenhalgh, Peter Tennant, Rachael Gregson, Eddie Clutton, James Nixon, Chris Proudfoot, Stefano Guido, Simon G. Lillico, C. Bruce A. Whitelaw, Jui-Yun Lu, Sandra L. Hofmann, Sean Ekins, Mark S. Sands, Thomas M. Wishart, Jonathan D. Cooper

Publikováno v: The Journal of Clinical Investigation, Vol 132, Iss 20 (2022)

CLN1 disease, also called infantile neuronal ceroid lipofuscinosis (NCL) or infantile Batten disease, is a fatal neurodegenerative lysosomal storage disorder resulting from mutations in the CLN1 gene encoding the soluble lysosomal enzyme palmitoyl-pr

Externí odkaz: https://doaj.org/article/fb7adb2cd6174d5a9c38555ece25def7

Modelling Neurological Diseases in Large Animals: Criteria for Model Selection and Clinical Assessment

Autor: Samantha L. Eaton, Fraser Murdoch, Nina M. Rzechorzek, Gerard Thompson, Claudia Hartley, Benjamin Thomas Blacklock, Chris Proudfoot, Simon G. Lillico, Peter Tennant, Adrian Ritchie, James Nixon, Paul M. Brennan, Stefano Guido, Nadia L. Mitchell, David N. Palmer, C. Bruce A. Whitelaw, Jonathan D. Cooper, Thomas M. Wishart

Publikováno v: Cells, Vol 11, Iss 17, p 2641 (2022)

Issue: The impact of neurological disorders is recognised globally, with one in six people affected in their lifetime and few treatments to slow or halt disease progression. This is due in part to the increasing ageing population, and is confounded b

Externí odkaz: https://doaj.org/article/f845c8ece4d54008a0fb30760828a416

Precurved, Fiber-Reinforced Actuators Enable Pneumatically Efficient Replication of Complex Biological Motions

Autor: Melissa Klein, Yiling Fan, Gary Menary, Lucy Hu, Dominik Gau, Ellen T. Roche, James Nixon

Publikováno v: Soft Robotics. 9:293-308

Much of the research on bioinspired soft robotics has focused on capturing the interplay of biological form and function. However, existing soft robotic actuators are mostly made with linear or planar fabrication orientations that do not represent th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a51ad6ff8d0b58fd93a5f49aec4d5313
https://doi.org/10.1089/soro.2020.0087

Experimental characterisation on the behaviour of PLLA for stretch blowing moulding of bioresorbable vascular scaffolds

Autor: Huidong Wei, Shiyong Yan, James Nixon, Gary Menary, Fraser Buchanan

Publikováno v: Wei, H, Menary, G, Buchanan, F, Yan, S & Nixon, J 2020, ' Experimental characterisation on the behaviour of PLLA for stretch blowing moulding of bioresorbable vascular scaffolds ', International Journal of Material Forming . https://doi.org/10.1007/s12289-020-01539-y

Processing tubes from poly (l-lactic acid) (PLLA) by stretch blow moulding (SBM) is used in the manufacture of bioresorbable vascular scaffolds (BVS) to improve their mechanical performance. To better understand this processing technique, a novel exp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::885940bcf843067e345607637ce1221d
https://doi.org/10.1007/s12289-020-01539-y