Zobrazeno 1 - 10
of 55
pro vyhledávání: '"James Herrington"'
Autor:
Sateja Paradkar, Adam Hendricson, Mark Plummer, Ranjini K. Sundaram, James Herrington, Denton Hoyer, Ranjit S. Bindra, Yulia V. Surovtseva, Piyasena Hewawasam
Publikováno v:
Oncotarget
Glioblastoma (GBM) is the most common primary malignant tumor of the central nervous system with a dismal prognosis. Locoregional failure is common despite high doses of radiation therapy, which has prompted great interest in developing novel strateg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54b96f25b0746c867fcdee576b3c9434
https://doi.org/10.18632/oncotarget.27933
https://doi.org/10.18632/oncotarget.27933
Autor:
James W. Murphy, Eric M. Rosenberg, Georgios Pantouris, James Herrington, Elias Lolis, Deepa Rajasekaran
Publikováno v:
Acta Crystallographica. Section D, Structural Biology
The chemokine CXCL13 relies on its N-terminus for signaling, but minor length and side-chain variations still result in a agonistic forms of the protein. Two crystal structures reveal that both the N-terminus and the C-terminal extension of the prote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4878b14b6e42a11d853072b4bef65109
https://doi.org/10.1107/s2059798320011687
https://doi.org/10.1107/s2059798320011687
Autor:
Zachary T.K. Gannam, Haya Jamali, Oh Sang Kweon, James Herrington, Shanelle R. Shillingford, Christina Papini, Erik Gentzel, Elias Lolis, Anton M. Bennett, Jonathan A. Ellman, Karen S. Anderson
Publikováno v:
European Journal of Medicinal Chemistry. 243:114712
Mitogen-activated protein kinase (MAPK) phosphatase 5 (MKP5) is responsible for regulating the activity of the stress-responsive MAPKs and has been put forth as a potential therapeutic target for a number of diseases, including dystrophic muscle dise
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a750c6a3cfba0e7a03b2a7f970c46ac
https://doi.org/10.1016/j.ejmech.2022.114712
https://doi.org/10.1016/j.ejmech.2022.114712
Autor:
Carolyn Diane Dzierba, Linda J. Bristow, Ramkumar Rajamani, Jie Chen, Rick L. Pieschl, Sing-Yuen Sit, Brian Lee Venables, Michele Matchett, Ronald J. Knox, Lorin A. Thompson, Nicholas A. Meanwell, Yong-Jin Wu, Jason M. Guernon, James Herrington
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 29:659-663
Screening of 100 acylsulfonamides from the Bristol-Myers Squibb compound collection identified the C3-cyclohexyl indole 6 as a potent Nav1.7 inhibitor. Replacement of the C2 furanyl ring of 6 with a heteroaryl moiety or truncation of this group led t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2f347d20e2f2ebee9e7e423555c27787
https://doi.org/10.1016/j.bmcl.2018.12.013
https://doi.org/10.1016/j.bmcl.2018.12.013
Autor:
Dr. Callie Raulfs-Wang, PhD, Cameron Bess, PhD, Robert Gasior, Kathleen Handley, PhD, James Herrington, PhD, Elizabeth Higgs, MD, Vesna Kutlesic, PhD, Sybil Phillip, MS, Elizabeth Sharp, PhD, Annica Wayman, PhD
Publikováno v:
The Lancet Global Health, Vol 2, Iss S1, p S48 (2014)
Background: The Partnership for Enhanced Engagement in Research (PEER) Health programme, funded by the United States Agency for International Development (USAID), is a new research partnership programme that directly supports researchers from develop
Externí odkaz:
https://doaj.org/article/c03c8d7d5a7b4b989d2a7ff6c8810955
Autor:
Carolyn Diane Dzierba, Debra J. Post-Munson, Ronald J. Knox, Lorin A. Thompson, Shuya Wang, Matthew G. Soars, Michele Matchett, Linda J. Bristow, James Herrington, Clotilde Bourin, Amy Newton, Rick L. Pieschl, Eric Shields, Amy Easton, Kathy Mosure, Guanglin Luo, Kimberly Newberry, Ling Chen, John D. Graef, Arun K. Senapati, Nicholas A. Meanwell, Digavalli V. Sivarao
Publikováno v:
Journal of Medicinal Chemistry. 62:831-856
3-Aryl-indole and 3-aryl-indazole derivatives were identified as potent and selective Nav1.7 inhibitors. Compound 29 was shown to be efficacious in the mouse formalin assay and also reduced complete Freund’s adjuvant (CFA)-induced thermal hyperalge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8738aee38a77abf37b839d8d841c0ca8
https://doi.org/10.1021/acs.jmedchem.8b01550
https://doi.org/10.1021/acs.jmedchem.8b01550
Autor:
Jun Yu, Jonathan A. Ellman, Laura Abriola, Peter C. Gareiss, Kisuk Min, Haya Jamali, Lei Zhang, Argyrios Tzouvelekis, Karen S. Anderson, Elias Lolis, Shanelle R. Shillingford, Naftali Kaminski, Georgios Pantouris, Anton M. Bennett, Zachary T. K. Gannam, James Herrington, Xinbo Zhang
Publikováno v:
Sci Signal
The mitogen-activated protein kinase (MAPK) phosphatases (MKPs) have been considered "undruggable," but their position as regulators of the MAPKs makes them promising therapeutic targets. MKP5 has been suggested as a potential target for the treatmen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6944fd4e45381dd55a10a9fcde03d173
https://doi.org/10.1126/scisignal.aba3043
https://doi.org/10.1126/scisignal.aba3043
Autor:
Nicholas A. Meanwell, Kevin J. Robbins, Carolyn Diane Dzierba, Rick L. Pieschl, Ramkumar Rajamani, James Herrington, Lorin A. Thompson, Andrea McClure, Yong-Jin Wu, Michele Matchett, Ronald J. Knox, Brian Lee Venables, Jason M. Guernon, Linda J. Bristow, Richard E. Olson
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 28:958-962
Replacement of the piperidine ring in the lead benzenesulfonamide Nav1.7 inhibitor 1 with a weakly basic morpholine core resulted in a significant reduction in Nav1.7 inhibitory activity, but the activity was restored by shortening the linkage from m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e7ad493840369e26cbfb8ea5aabd0b90
https://doi.org/10.1016/j.bmcl.2018.01.035
https://doi.org/10.1016/j.bmcl.2018.01.035
Autor:
Kathleen W. Mosure, Michele Matchett, Ronald J. Knox, Richard E. Olson, Joanne J. Bronson, Nicholas A. Meanwell, Matthew G. Soars, Linda J. Bristow, Ramkumar Rajamani, James Herrington, Amy Easton, Digavalli V. Sivarao, Dawn D. Parker, Rick L. Pieschl, Ping Chen, Guanglin Luo, Omar S. Barnaby, Lorin A. Thompson, Yong-Jin Wu, Andrea McClure, Jason M. Guernon, Amy Newton, Alicia Ng, Clotilde Bourin, Carolyn Diane Dzierba
Publikováno v:
Bioorganic & Medicinal Chemistry. 25:5490-5505
Since zwitterionic benzenesulfonamide Nav1.7 inhibitors suffer from poor membrane permeability, we sought to eliminate this characteristic by replacing the basic moiety with non-basic bicyclic acetals and monocyclic ethers. These efforts led to the d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::120b30199f8465162b72cfc311e05f8b
https://doi.org/10.1016/j.bmc.2017.08.012
https://doi.org/10.1016/j.bmc.2017.08.012
Autor:
David R. Langley, Rick L. Pieschl, John Watson, Simon Low, Linda J. Bristow, Debra J. Post-Munson, Michael K. Ahlijanian, Ramkumar Rajamani, Sophie Wu, James Herrington, Mian Gao, Lisa Megson, Iyoncy Rodrigo, David L. Wensel
Publikováno v:
Molecular Pharmacology. 92:310-317
The NaV1.7 voltage-gated sodium channel is implicated in human pain perception by genetics. Rare gain of function mutations in NaV1.7 lead to spontaneous pain in humans whereas loss of function mutations results in congenital insensitivity to pain. H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::07940ab23c226013ba900bf2c7333fa2
https://doi.org/10.1124/mol.117.108712
https://doi.org/10.1124/mol.117.108712