Zobrazeno 1 - 10
of 625
pro vyhledávání: '"James G. Krueger"'
Publikováno v:
Dermatology and Therapy, Vol 14, Iss 10, Pp 2827-2839 (2024)
Abstract Background Psoriasis, a chronic, immune-mediated, inflammatory disease, affects 2‒3% of the population. Tyrosine kinase 2 (TYK2) mediates cytokine signaling involved in adaptive [interleukin (IL)-12, IL-23] and innate (type-I interferons)
Externí odkaz:
https://doaj.org/article/d0ab2ef8ef8b48109a8a42b70e3e4efc
Autor:
Andrew Blauvelt, Yanqing Chen, Patrick J. Branigan, Xuejun Liu, Samuel DePrimo, Brice E. Keyes, Monica Leung, Steven Fakharzadeh, Ya-Wen Yang, Ernesto J. Muñoz-Elías, James G. Krueger, Richard G. Langley
Publikováno v:
JID Innovations, Vol 4, Iss 5, Pp 100297- (2024)
IL-23 is a cytokine produced by myeloid cells that drives the T helper 17 pathway and plays an essential role in the pathophysiology of plaque psoriasis. IL-23 activation initiates a cascade of cytokines subsequently inducing the expression of many p
Externí odkaz:
https://doaj.org/article/3cdb3a1625bb4d1bb4480d62cb6cb130
Autor:
Thomas Morgan Li, Victoria Zyulina, Ethan S Seltzer, Marija Dacic, Yurii Chinenov, Andrea R Daamen, Keila R Veiga, Noa Schwartz, David J Oliver, Pamela Cabahug-Zuckerman, Jose Lora, Yong Liu, William D Shipman, William G Ambler, Sarah F Taber, Karen B Onel, Jonathan H Zippin, Mehdi Rashighi, James G Krueger, Niroshana Anandasabapathy, Inez Rogatsky, Ali Jabbari, Carl P Blobel, Peter E Lipsky, Theresa T Lu
Publikováno v:
eLife, Vol 13 (2024)
The autoimmune disease lupus erythematosus (lupus) is characterized by photosensitivity, where even ambient ultraviolet radiation (UVR) exposure can lead to development of inflammatory skin lesions. We have previously shown that Langerhans cells (LCs
Externí odkaz:
https://doaj.org/article/1893d48ef7494361b3b8a171e812c346
Autor:
Peter E Lipsky, Yong Liu, Niroshana Anandasabapathy, Mehdi Rashighi, Jose Lora, Yurii Chinenov, Ali Jabbari, Carl P Blobel, Thomas M Li, William D Shipman, Theresa T Lu, Noa Schwartz, David J Oliver, Keila R Veiga, James G Krueger, William G Ambler, Andrea R Daamen, Karen B Onel, Ethan S Seltzer, Pamela Zuckerman, Victoria Zyulina, Marija Dacic, Sarah F Taber, Jonathan H Zippin, Inez Rogatsky
Publikováno v:
Lupus Science and Medicine, Vol 11, Iss Suppl 2 (2024)
Externí odkaz:
https://doaj.org/article/3f6a6b1f4dbb430b9f617fea6552add3
Autor:
James G. Krueger, Kilian Eyerich, Vijay K. Kuchroo, Christopher T. Ritchlin, Maria T. Abreu, M. Merle Elloso, Anne Fourie, Steven Fakharzadeh, Jonathan P. Sherlock, Ya-Wen Yang, Daniel J. Cua, Iain B. McInnes
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Interleukin (IL)-23, an IL-12 cytokine family member, is a hierarchically dominant regulatory cytokine in a cluster of immune-mediated inflammatory diseases (IMIDs), including psoriasis, psoriatic arthritis, and inflammatory bowel disease. We review
Externí odkaz:
https://doaj.org/article/3fb972d7f9ef4534a189cd8ccc187a46
Publikováno v:
Skin Health and Disease, Vol 4, Iss 2, Pp n/a-n/a (2024)
Abstract Background Generalised pustular psoriasis (GPP) is a rare and chronic skin disease historically treated with therapies that were originally intended to treat plaque psoriasis (PsO). However, GPP and plaque PsO have distinct pathogeneses and
Externí odkaz:
https://doaj.org/article/e004f29b201d4ed5ab55f39574df45b5
Autor:
Qian Xiao, Joseph Mears, Aparna Nathan, Kazuyoshi Ishigaki, Yuriy Baglaenko, Noha Lim, Laura A. Cooney, Kristina M. Harris, Mark S. Anderson, David A. Fox, Dawn E. Smilek, James G. Krueger, Soumya Raychaudhuri
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract Psoriasis is a chronic, systemic inflammatory condition primarily affecting skin. While the role of the immune compartment (e.g., T cells) is well established, the changes in the skin compartment are more poorly understood. Using longitudina
Externí odkaz:
https://doaj.org/article/dbc9e298d8244b0593bbd1a55d0a25b0
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Generalized pustular psoriasis (GPP) is a rare, chronic, inflammatory skin disorder characterized by recurrent flares associated with skin erythema, desquamation, and widespread superficial sterile pustules, which may be severe (“lakes of pus”).
Externí odkaz:
https://doaj.org/article/1ebaf70efb874a9e8f9a85113d0f2d54
Autor:
James G. Krueger
Good stewardship of nature and the earth--those foundations upon which life depends--is our most pressing challenge, requiring a monumental and relentlessly single-minded unity of purpose. Yet in America, the cause of conservation suffers while the p
Autor:
Joseph Han, Aneesh Agarwal, Jade N. Young, Shayan Owji, Yen Luu, Dina Poplausky, Daniel Yassky, Yeriel Estrada, Jonathan Ungar, James G. Krueger, Nicholas Gulati
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-7 (2022)
Abstract Immune checkpoint inhibitors (ICIs) such as pembrolizumab have revolutionized the treatment of advanced melanoma, but many patients do not respond to ICIs alone, and thus there is need for additional treatment options. Topical immunomodulato
Externí odkaz:
https://doaj.org/article/d6e67a2fe1c6416fb2a6433de815f5be