Zobrazeno 1 - 10
of 184
pro vyhledávání: '"James C. Powers"'
Autor:
Sarina Gloeckl, Charles W. Armitage, Melisa Merdanovic, Joel D. A. Tyndall, Kenneth W. Beagley, Cynthia B. Whitchurch, Józef Oleksyszyn, Lynne Turnbull, Peter Timms, Pooja Patel, Vanissa A. Ong, Michael Ehrmann, Wilhelmina M. Huston, Matthew Bogyo, John A. Allan, James C. Powers, Martijn Verdoes
Publikováno v:
Molecular Microbiology. 89:676-689
The mechanistic details of the pathogenesis of Chlamydia, an obligate intracellular pathogen of global importance, have eluded scientists due to the scarcity of traditional molecular genetic tools to investigate this organism. Here we report a chemic
Autor:
Matthew Bogyo, Sanjay K. Jain, Charles S. Craik, Florencia La Greca, Anthony J. O’Donoghue, Alvaro A. Ordonez, Christian S. Lentz, James C. Powers, Marcin Drag, Christopher J. Schulze, Paulina Kasperkiewicz
Publikováno v:
ACS Infectious Diseases
Although serine proteases are important mediators of Mycobacterium tuberculosis (Mtb) virulence, there are currently no tools to selectively block or visualize members of this family of enzymes. Selective reporter substrates or activity-based probes
Autor:
Amy J. Campbell, Victoria E. Albrow, James C. Powers, Elizabeth L. Ponder, Junpeng Xiao, Miklós Békés, Edgar Deu, Urša Pečar Fonović, Marcin Drag, Jowita Mikolajczyk, Brittany A. Leader, Matthew Bogyo, Aimee Shen, Guy S. Salvesen
Publikováno v:
Chemistry & Biology. 18:711-721
SummarySmall ubiquitin-related modifier (SUMO) is implicated in the regulation of numerous biological processes including transcription, protein localization, and cell cycle control. Protein modification by SUMO is found in Plasmodium falciparum; how
Autor:
Michelle Brouner, Crystal Fagan, Asli Ovat, Jan Dvorák, Daniel Sojka, Petr Kopáček, Conor R. Caffrey, Elizabeth Hansell, James C. Powers, Fanuel Muindi, James H. McKerrow
Publikováno v:
Journal of Medicinal Chemistry. 52:7192-7210
Aza-peptide Michael acceptors and epoxides with the general structure of YCO-Ala-Ala-AAsn-trans-CH horizontal lineCHCOR and YCO-Ala-Ala-AAsn-EP-COR, respectively, are shown to be potent inhibitors of asparaginyl endopeptidases (legumains) from the bl
Autor:
Victoria E. Albrow, Aimee Shen, Andrew Guzzetta, K. Christopher Garcia, James C. Powers, Patrick J. Lupardus, Matthew Bogyo
Publikováno v:
Nature chemical biology
MARTX toxins modulate the virulence of a number of Gram-negative Vibrio species. This family of toxins is defined by the presence of a cysteine protease domain (CPD), which proteolytically activates the Vibrio cholerae MARTX toxin. Although recent st
Autor:
Jin Qian, Zhaozhao Li, Dominic Cuerrier, Robert L. Campbell, James C. Powers, Peter L. Davies
Publikováno v:
Journal of Medicinal Chemistry. 51:5264-5270
Calpains are intracellular cysteine proteases that catalyze the cleavage of target proteins in response to Ca(2+) signaling. When Ca(2+) homeostasis is disrupted, calpain overactivation causes unregulated proteolysis, which can contribute to diseases
Autor:
Karen Ellis James, Maia M. Cherney, Jie Liu, Ting-Wai Lee, James C. Powers, Michael N.G. James, Lindsay D. Eltis
Publikováno v:
Journal of Molecular Biology
The SARS coronavirus main peptidase (SARS-CoV M(pro)) plays an essential role in the life-cycle of the virus and is a primary target for the development of anti-SARS agents. Here, we report the crystal structure of M(pro) at a resolution of 1.82 Angs
Exploring the S4 and S1 Prime Subsite Specificities in Caspase-3 with Aza-Peptide Epoxide Inhibitors
Autor:
Stjepan Jelakovic, Juliana L. Asgian, Markus G. Grütter, Rajkumar Ganesan, Zhao Zhao Li, Amy J. Campbell, James C. Powers
Publikováno v:
Biochemistry. 45:9059-9067
Caspase-3 is a prototypic executioner caspase that plays a central role in apoptosis. Aza-peptide epoxides are a novel class of irreversible inhibitors that are highly specific for clan CD cysteine proteases. The five crystal structures of caspase-3-
Publikováno v:
Remediation Journal. 16:71-80
This article describes the design, implementation, and operating results for an ex situ ultraviolet/hydrogen peroxide (UVP) system to treat methyl tert-butyl ether (MTBE) in extracted groundwater. The UVP modification was designed to reduce the opera
Autor:
Carly Huitema, Karen Ellis James, Ting-Wai Lee, Maia M. Cherney, Jie Liu, James C. Powers, Michael N.G. James, Lindsay D. Eltis
Publikováno v:
Journal of Molecular Biology
The main peptidase (M(pro)) from the coronavirus (CoV) causing severe acute respiratory syndrome (SARS) is one of the most attractive molecular targets for the development of anti-SARS agents. We report the irreversible inhibition of SARS-CoV M(pro)