Zobrazeno 1 - 10
of 21
pro vyhledávání: '"James, Wacker"'
Autor:
Ljubomir Buturovic, Hong Zheng, Benjamin Tang, Kevin Lai, Win Sen Kuan, Mark Gillett, Rahul Santram, Maryam Shojaei, Raquel Almansa, Jose Ángel Nieto, Sonsoles Muñoz, Carmen Herrero, Nikolaos Antonakos, Panayiotis Koufargyris, Marina Kontogiorgi, Georgia Damoraki, Oliver Liesenfeld, James Wacker, Uros Midic, Roland Luethy, David Rawling, Melissa Remmel, Sabrina Coyle, Yiran E. Liu, Aditya M. Rao, Denis Dermadi, Jiaying Toh, Lara Murphy Jones, Michele Donato, Purvesh Khatri, Evangelos J. Giamarellos-Bourboulis, Timothy E. Sweeney
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-16 (2022)
Abstract Predicting the severity of COVID-19 remains an unmet medical need. Our objective was to develop a blood-based host-gene-expression classifier for the severity of viral infections and validate it in independent data, including COVID-19. We de
Externí odkaz:
https://doaj.org/article/ee4e353ebc1a4a9cbf2de80046f1b3f4
Autor:
Michael B. Mayhew, Ljubomir Buturovic, Roland Luethy, Uros Midic, Andrew R. Moore, Jonasel A. Roque, Brian D. Shaller, Tola Asuni, David Rawling, Melissa Remmel, Kirindi Choi, James Wacker, Purvesh Khatri, Angela J. Rogers, Timothy E. Sweeney
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
Diagnosing acute infections based on transcriptional host response shows promise, but generalizability is wanting. Here, the authors use a co-normalization framework to train a classifier to diagnose acute infections and apply it to independent data
Externí odkaz:
https://doaj.org/article/1514bf7fdf6d4f5db8c9b6afeda1ce2b
Autor:
Scott C. Brakenridge, MD, Petr Starostik, MD, Gabriella Ghita, PhD, Uros Midic, PhD, Dijoia Darden, MD, Brittany Fenner, MD, James Wacker, MS, Philip A. Efron, MD, Oliver Liesenfeld, MD, Timothy E. Sweeney, MD, PhD, Lyle L. Moldawer, PhD
Publikováno v:
Critical Care Explorations, Vol 3, Iss 10, p e0554 (2021)
OBJECTIVES:. Clinically deployable methods for the rapid and accurate prediction of sepsis severity that could elicit a meaningful change in clinical practice are currently lacking. We evaluated a whole-blood, multiplex host-messenger RNA expression
Externí odkaz:
https://doaj.org/article/3754813dc9074e36a8aea4f72f4dd31d
Publikováno v:
Forests, Vol 12, Iss 4, p 492 (2021)
This paper is a review of published studies involving the use of ground penetrating radar (GPR) on wood structures. It also contains background information to help the reader understand how GPR functions. The use of GPR on wood structures began to gr
Externí odkaz:
https://doaj.org/article/96aca159dfaa41e9b3808788ae8979a7
Autor:
Noa Galtung, Eva Diehl-Wiesenecker, Dana Lehmann, Natallia Markmann, Wilma H. Bergström, James Wacker, Oliver Liesenfeld, Michael Mayhew, Ljubomir Buturovic, Roland Luethy, Timothy E. Sweeney, Rudolf Tauber, Kai Kappert, Rajan Somasundaram, Wolfgang Bauer
Publikováno v:
European Journal of Emergency Medicine. 29:357-365
mRNA-based host response signatures have been reported to improve sepsis diagnostics. Meanwhile, prognostic markers for the rapid and accurate prediction of severity in patients with suspected acute infections and sepsis remain an unmet need. IMX-SEV
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c65442d556c41db25dae11e313486f28
https://doi.org/10.1097/mej.0000000000000931
https://doi.org/10.1097/mej.0000000000000931
Publikováno v:
Forests, Vol 11, Iss 2, p 230 (2020)
An object detection method of ground-penetrating radar (GPR) signals using empirical mode decomposition (EMD) and dynamic time warping (DTW) is proposed in this study. Two groups of timber specimens were examined. The first group comprised of Douglas
Externí odkaz:
https://doaj.org/article/0f1971425dee4c7c8770d3be200012bf
Autor:
Scott C. Brakenridge, Uan-I Chen, Tyler Loftus, Ricardo Ungaro, Marvin Dirain, Austin Kerr, Luer Zhong, Rhonda Bacher, Petr Starostik, Gabriella Ghita, Uros Midic, Dijoia Darden, Brittany Fenner, James Wacker, Philip A. Efron, Oliver Liesenfeld, Timothy E. Sweeney, Lyle L. Moldawer
Publikováno v:
JAMA network open. 5(7)
Rapid and accurate discrimination of sepsis and its potential severity currently require multiple assays with slow processing times that are often inconclusive in discerning sepsis from sterile inflammation.To analyze a whole-blood, multivalent, host
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::396107a49b193f9dcb584274790b645a
https://pubmed.ncbi.nlm.nih.gov/35819783
https://pubmed.ncbi.nlm.nih.gov/35819783
Autor:
James Wacker, Timothy E. Sweeney, Oliver Liesenfeld, Wolfgang Bauer, Rajan Somasundaram, Ljubomir Buturovic, Roland Luethy, Dana Lehmann, Kai Kappert, Noa Galtung, Henry K Cheng, Rudolf Tauber
Publikováno v:
Critical Care Medicine
Supplemental Digital Content is available in the text.
OBJECTIVES: The rapid diagnosis of acute infections and sepsis remains a serious challenge. As a result of limitations in current diagnostics, guidelines recommend early antimicrobials for s
OBJECTIVES: The rapid diagnosis of acute infections and sepsis remains a serious challenge. As a result of limitations in current diagnostics, guidelines recommend early antimicrobials for s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1afa9269ea47e1bef96aad74a2f4e43b
https://pubmed.ncbi.nlm.nih.gov/34529611
https://pubmed.ncbi.nlm.nih.gov/34529611
Autor:
Kristopher, Johnson, Angela, VandenHull, Tyler, Remund, Kathryn, Pohlson, Valerie, Bares, James, Wacker, Patrick, Kelly
Publikováno v:
S D Med
INTRODUCTION: Pulmonary embolism (PE) is a significant disease process that affects an estimated 117 cases per 100,000 person-years. Chronic pulmonary hypertension (CPH) is a long-term complication associated with acute PE which has a significant cos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6047c30673c8db8e09bd80e3d81f72a7
https://pubmed.ncbi.nlm.nih.gov/34161687
https://pubmed.ncbi.nlm.nih.gov/34161687
Autor:
Oliver Liesenfeld, Miryam Martín-Ballesteros, Alicia Ortega, Luis García-Ortiz, Carmen Herrero-Rodríguez, Raquel Almansa, Maria del Pilar Vicente-Andres, Amanda de la Fuente, Maria del Mar Rodilla-Carvajal, Maria Jesus Alonso-Ramos, Misericordia Martínez-Huélamo, James Wacker, Timothy E. Sweeney, Jesus F. Bermejo-Martin, Jose Angel Nieto-Barbero
Publikováno v:
European Journal of Clinical Investigation. 51
BACKGROUND: Fever-7 is a test evaluating host mRNA expression levels of IFI27, JUP, LAX, HK3, TNIP1, GPAA1 and CTSB in blood able to detect viral infections. This test has been validated mostly in hospital settings. Here we have evaluated Fever-7 to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::532c6d145ab6664959160ba11b07accb
https://doi.org/10.1111/eci.13626
https://doi.org/10.1111/eci.13626