Zobrazeno 1 - 10
of 347
pro vyhledávání: '"James, Versalovic"'
Autor:
Santosh Thapa, Ruth Ann Luna, Bruno P. Chumpitazi, Numan Oezguen, Susan M. Abdel‐Rahman, Uttam Garg, Salma Musaad, James Versalovic, Gregory L. Kearns, Robert J. Shulman
Publikováno v:
Clinical and Translational Science, Vol 15, Iss 4, Pp 1036-1049 (2022)
Abstract Peppermint oil (PMO) is effective in the treatment of functional abdominal pain disorders, but its mechanism of action is unclear. Evidence suggests PMO has microbicidal activity. We investigated the effect of three different doses of PMO on
Externí odkaz:
https://doaj.org/article/ef014f884ec24924b5923f470789c090
Autor:
Mahesh Krishna, Melinda Engevik, Karen Queliza, Savini Britto, Rajesh Shah, Wenly Ruan, Hongtao Wang, James Versalovic, Richard Kellermayer
Publikováno v:
FASEB BioAdvances, Vol 4, Iss 2, Pp 109-120 (2022)
Abstract The purpose of our experiment was to explore how stochastic (inter‐individual variation) gut microbiome composition may link to inflammatory bowel disease (IBD) susceptibility and guide the development of a perinatal preventative probiotic
Externí odkaz:
https://doaj.org/article/3f453d053cac4a7b8a5c9a8302470a66
Autor:
Zhongcheng Shi, PhD, Yuko Mori-Akiyama, MD, Wa Du, PhD, Robert Fultz, PhD, Yanling Zhao, PhD, Wenly Ruan, MD, Susan Venable, Melinda A. Engevik, PhD, James Versalovic, MD, PhD
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 13, Iss 3, Pp 717-737 (2022)
Background & Aims: We previously showed that histamine suppressed inflammation-associated colonic tumorigenesis through histamine type 2 receptor (H2R) signaling in mice. This study aimed to precisely elucidate the downstream effects of H2R activatio
Externí odkaz:
https://doaj.org/article/dede34a6854d4efa898e633b9abcc4bd
Autor:
Melinda A. Engevik, Heather A. Danhof, Anne Hall, Kristen A. Engevik, Thomas D. Horvath, Sigmund J. Haidacher, Kathleen M. Hoch, Bradley T. Endres, Meghna Bajaj, Kevin W. Garey, Robert A. Britton, Jennifer K. Spinler, Anthony M. Haag, James Versalovic
Publikováno v:
BMC Microbiology, Vol 21, Iss 1, Pp 1-26 (2021)
Abstract Background Bifidobacteria are commensal microbes of the mammalian gastrointestinal tract. In this study, we aimed to identify the intestinal colonization mechanisms and key metabolic pathways implemented by Bifidobacterium dentium. Results B
Externí odkaz:
https://doaj.org/article/4b0f1ff8289a499390185793dc45b7e1
Autor:
Thomas D. Horvath, Faith D. Ihekweazu, Sigmund J. Haidacher, Wenly Ruan, Kristen A. Engevik, Robert Fultz, Kathleen M. Hoch, Ruth Ann Luna, Numan Oezguen, Jennifer K. Spinler, Anthony M. Haag, James Versalovic, Melinda A. Engevik
Publikováno v:
iScience, Vol 25, Iss 5, Pp 104158- (2022)
Summary: Gut microbes can synthesize multiple neuro-active metabolites. We profiled neuro-active compounds produced by the gut commensal Bacteroides ovatus in vitro and in vivo by LC-MS/MS. We found that B. ovatus generates acetic acid, propionic aci
Externí odkaz:
https://doaj.org/article/9265eb55b5e3455eacfd6e2f6f4ffdf8
Autor:
Melinda A. Engevik, Berkley Luck, Chonnikant Visuthranukul, Faith D. Ihekweazu, Amy C. Engevik, Zhongcheng Shi, Heather A. Danhof, Alexandra L. Chang-Graham, Anne Hall, Bradley T. Endres, Sigmund J. Haidacher, Thomas D. Horvath, Anthony M. Haag, Sridevi Devaraj, Kevin W. Garey, Robert A. Britton, Joseph M. Hyser, Noah F. Shroyer, James Versalovic
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 11, Iss 1, Pp 221-248 (2021)
Background & Aims: The human gut microbiota can regulate production of serotonin (5-hydroxytryptamine [5-HT]) from enterochromaffin cells. However, the mechanisms underlying microbial-induced serotonin signaling are not well understood. Methods: Adul
Externí odkaz:
https://doaj.org/article/104cb38cf9ef42919922904300f90cbe
Autor:
Maxim D. Seferovic, Mahmoud Mohammad, Ryan M. Pace, Melinda Engevik, James Versalovic, Lars Bode, Morey Haymond, Kjersti M. Aagaard
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-18 (2020)
Abstract Human milk is the optimal nutrition source for infants, and oligosaccharides represent the third most abundant component in milk after lactose and fat. Human milk oligosaccharides (HMO) are favorable macromolecules which are, interestingly,
Externí odkaz:
https://doaj.org/article/6adbd5a8c9794016806a8a00b6fea471
Autor:
Sridevi Devaraj, Izmarie Poventud-Fuentes, Matthew Girotto, Jermaine Monroe, Julie Boom, George Delclos, James Versalovic
Publikováno v:
Practical Laboratory Medicine, Vol 28, Iss , Pp e00261- (2022)
To gain insights on the heterogeneity of immune responses to vaccination against SARS-CoV-2 and to identify factors that could make individuals vulnerable to infection due to lack of response to vaccination, our hospital started offering free volunta
Externí odkaz:
https://doaj.org/article/562f0dc9aa404c7ca4216ec985622911
Publikováno v:
Microbial Cell Factories, Vol 18, Iss 1, Pp 1-18 (2019)
Abstract Background Histamine is a key mediator of the anti-inflammatory activity conferred by the probiotic organism Lactobacillus reuteri ATCC PTA 6475 in animal models of colitis and colorectal cancer. In L. reuteri, histamine synthesis and secret
Externí odkaz:
https://doaj.org/article/0ff26f94d65446aea173821d023a9c20
Autor:
Prapaporn Boonma, Jordan M. Shapiro, Emily B. Hollister, Shyam Badu, Qinglong Wu, Erica M. Weidler, Bincy P. Abraham, Sridevi Devaraj, Ruth Ann Luna, James Versalovic, Margaret M. Heitkemper, Tor C. Savidge, Robert J. Shulman
Publikováno v:
Frontiers in Pain Research, Vol 2 (2021)
Background: Little is known regarding the clinical impact of treatment and treatment duration of probiotic VSL#3 on gut and microbiome function in irritable bowel syndrome (IBS). As part of a safety trial, we assessed the effect of VSL#3 treatment du
Externí odkaz:
https://doaj.org/article/b17dc45b76f14cabbd64631563111740