Zobrazeno 1 - 10
of 273
pro vyhledávání: '"James, Sneyd"'
Publikováno v:
Frontiers in Systems Biology, Vol 4 (2024)
The concentration of free cytosolic Ca2+ is a critical second messenger in almost every cell type, with the signal often being carried by the period of oscillations, or spikes, in the cytosolic Ca2+ concentration. We have previously studied how Ca2+
Externí odkaz:
https://doaj.org/article/b202a630471c4ed18986bdee9a74b97d
Autor:
Zijian Zeng, Mengxin Cheng, Meng Li, Tao Wang, Fuqiang Wen, Michael J. Sanderson, James Sneyd, Yongchun Shen, Jun Chen
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
BALB/c and C57BL/6 mouse strains are widely used as animal model in studies of respiratory diseases, such as asthma. Asthma is characterized by airway hyperresponsiveness, which is eventually resulted from the excessive airway smooth muscle (ASM) con
Externí odkaz:
https://doaj.org/article/febcca5630c94857b017f7e4f52ca099
Autor:
Ryan E. Yoast, Scott M. Emrich, Xuexin Zhang, Ping Xin, Martin T. Johnson, Adam J. Fike, Vonn Walter, Nadine Hempel, David I. Yule, James Sneyd, Donald L. Gill, Mohamed Trebak
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
The essential role of ORAI1 channels in receptor-evoked Ca2+ signaling is well understood, but the roles of ORAI2 and ORAI3 remained obscure. Here authors show that ORAI2 and ORAI3 channels multimerize with ORAI1 to expand the range of sensitivity of
Externí odkaz:
https://doaj.org/article/d0bad2674967414e8be76ad70168e97d
Publikováno v:
Biomolecules, Vol 12, Iss 10, p 1455 (2022)
The cytosolic concentration of free calcium ions ([Ca2+]) is an important intracellular messenger in most cell types, and the spatial distribution of [Ca2+] is often critical. In a salivary gland acinar cell, a polarised epithelial cell, whose princi
Externí odkaz:
https://doaj.org/article/8503e13b1f304b36aedd4cc8487ccdb4
Autor:
Takahiro Takano, Amanda M Wahl, Kai-Ting Huang, Takanori Narita, John Rugis, James Sneyd, David I Yule
Publikováno v:
eLife, Vol 10 (2021)
Salivary fluid secretion involves an intricate choreography of membrane transporters to result in the trans-epithelial movement of NaCl and water into the acinus lumen. Current models are largely based on experimental observations in enzymatically is
Externí odkaz:
https://doaj.org/article/70400a41f69e4069aa4ae68cad70958b
Publikováno v:
iScience, Vol 23, Iss 5, Pp - (2020)
Summary: Ca2+ oscillations that depend on inositol-1,4,5-trisphosphate (IP3) have been ascribed to biphasic Ca2+ regulation of the IP3 receptor (IP3R) or feedback mechanisms controlling IP3 levels in different cell types. IP3 uncaging in hepatocytes
Externí odkaz:
https://doaj.org/article/2d1b25963461437bafc2ba97b1a7269f
Publikováno v:
SIAM Journal on Applied Dynamical Systems. 21:982-1029
Phenomena in chemistry, biology and neuroscience are often modelled using ordinary differential equations (ODEs) in which the right-hand-side is comprised of terms which correspond to individual 'processes' or 'fluxes'. Frequently, these ODEs are cha
Publikováno v:
Bulletin of Mathematical Biology. 85
The existence and properties of intracellular waves of increased free cytoplasmic calcium concentration (calcium waves) are strongly affected by the binding and unbinding of calcium ions to a multitude of different buffers in the cell. These buffers
Publikováno v:
PLoS Computational Biology, Vol 13, Iss 2, p e1005275 (2017)
Saliva is an essential part of activities such as speaking, masticating and swallowing. Enzymes in salivary fluid protect teeth and gums from infectious diseases, and also initiate the digestion process. Intracellular calcium (Ca2+) plays a critical
Externí odkaz:
https://doaj.org/article/2a032bc58cbc441fbd130420785f054e
Publikováno v:
Bulletin of Mathematical Biology. 84
Saliva is produced in two stages in the salivary glands: the secretion of primary saliva by the acinus and the modification of saliva composition to final saliva by the intercalated and striated ducts. In order to understand the saliva modification p