Zobrazeno 1 - 9
of 9
pro vyhledávání: '"James, Schiemer"'
Autor:
James Schiemer, Andrew Maxwell, Reto Horst, Shenping Liu, Daniel P. Uccello, Kris Borzilleri, Nisha Rajamohan, Matthew F. Brown, Matthew F. Calabrese
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Bridging covalent ligand discovery with chimeric degrader design has emerged as a mechanism to target proteins that lack enzymatic activity or are intractable. Here, the authors use biochemical and cellular tools to deconvolute the role of covalent m
Externí odkaz:
https://doaj.org/article/8332ec11fd3e488aa9daf64205146e29
Autor:
Xidong Feng, Ye Che, Adam M. Gilbert, Reto Horst, Kris A. Borzilleri, Matthew Merrill Hayward, Carolyn A. Leverett, James Schiemer, Yilin Meng, Justin I. Montgomery, Matthew F. Calabrese, Mark C. Noe, Daniel P. Uccello, Stephen P. Brown, Matthew Frank Brown, Yingrong Xu
Publikováno v:
Nature Chemical Biology. 17:152-160
Heterobifunctional chimeric degraders are a class of ligands that recruit target proteins to E3 ubiquitin ligases to drive compound-dependent protein degradation. Advancing from initial chemical tools, protein degraders represent a mechanism of growi
Autor:
Andrew Levin, Shreeya Hegde, Michael R. Baldwin, Carolyn Okure, Athar H. Chishti, Edouard Vannier, William W. Bachovchin, Toshihiko Hanada, James Schiemer, Christopher Schwake
Publikováno v:
Biochem Biophys Res Commun
Malaria and babesiosis are bloodborne protozoan infections for which the emergence of drug-resistant strains poses a threat. Our previous phage display cDNA screens established the essentiality of Plasmodium falciparum signal peptide peptidase (SPP)
Autor:
James, Schiemer, Reto, Horst, Yilin, Meng, Justin I, Montgomery, Yingrong, Xu, Xidong, Feng, Kris, Borzilleri, Daniel P, Uccello, Carolyn, Leverett, Stephen, Brown, Ye, Che, Matthew F, Brown, Matthew M, Hayward, Adam M, Gilbert, Mark C, Noe, Matthew F, Calabrese
Publikováno v:
Nature chemical biology. 17(2)
Heterobifunctional chimeric degraders are a class of ligands that recruit target proteins to E3 ubiquitin ligases to drive compound-dependent protein degradation. Advancing from initial chemical tools, protein degraders represent a mechanism of growi
Autor:
Maima M. Kaiser, Toshihiko Hanada, Christopher Schwake, D. C. Ghislaine Mayer, Michael R. Baldwin, Yunzhe Lu, Athar H. Chishti, Haifa Almukadi, Shreeya Hegde, James Schiemer
Malaria remains a major global threat to human health and economic development. Microvascular lesions caused by Plasmodium falciparum–infected human erythrocytes/red blood cells are hallmarks of severe pathogenesis contributing to high mortality, p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::476f1f3d512a3d6e800b65d1d4e61a9b
https://europepmc.org/articles/PMC6356982/
https://europepmc.org/articles/PMC6356982/
Autor:
Suman Luthra, Graham M. West, Jeremy T. Starr, Matthew Frank Brown, Matthew F. Calabrese, Jinshan Chen, Hongyao Zhu, Xiayang Qiu, Daniel P. Uccello, Matthew Merrill Hayward, Jeanne S. Chang, Jotham Wadsworth Coe, Kathleen A. Farley, Kris A. Borzilleri, Mark C. Noe, Justin I. Montgomery, Adam M. Gilbert, Veerabahu Shanmugasundaram, Lara C. Czabaniuk, Robert M. Oliver, Carmen N. Garcia-Irrizary, Brandon P. Schuff, Chuong Nguyen, Yingrong Xu, James Schiemer, Jaymin C. Shah, Xidong Feng, Mark Niosi, Jennifer A. Young, WeiDong Ding, Ayman El-Kattan, Adelajda Zorba, James F. Smith
Proteolysis targeting chimeras (PROTACs) are heterobifunctional small molecules that simultaneously bind to a target protein and an E3 ligase, thereby leading to ubiquitination and subsequent degradation of the target. They present an exciting opport
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf434de63be490efb6416cf59a222839
https://europepmc.org/articles/PMC6077745/
https://europepmc.org/articles/PMC6077745/
Autor:
Jin-Sheng Huang, Glenn Merrill-Skoloff, Robert Flaumenhaft, Li Lin, Guy C. Le Breton, Athar H. Chishti, James Schiemer, Andrew Bohm
Integrins function as bi-directional signaling transducers that regulate cell-cell and cell-matrix signals across the membrane. A key modulator of integrin activation is talin, a large cytoskeletal protein that exists in an autoinhibited state in qui
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78454f9be185769961195c6747332124
https://europepmc.org/articles/PMC5207171/
https://europepmc.org/articles/PMC5207171/
Gα13 Switch Region 2 Binds to the Talin Head Domain and Activates αIIbβ3 Integrin in Human Platelets
Publikováno v:
The Journal of biological chemistry. 290(41)
Even though GPCR signaling in human platelets is directly involved in hemostasis and thrombus formation, the sequence of events by which G protein activation leads to αIIbβ3 integrin activation (inside-out signaling) is not clearly defined. We prev
Autor:
Robert Flaumenhaft, Athar H. Chishti, James Schiemer, Andrew Bohm, Glenn Merrill-Skoloff, Guy C. Le Breton
Publikováno v:
Blood. 128:712-712
Integrins function as bi-directional signaling transducers that regulate cell-cell and cell-matrix signals across the membrane. A key modulator of integrin activation is talin, a large cytoskeletal protein that exists in an autoinhibited state in qui