A randomised, double-blind, placebo-controlled trial of repeated nebulisation of non-viral cystic fibrosis transmembrane conductance regulator (CFTR) gene therapy in patients with cystic fibrosis

Autor: Eric WFW Alton, David K Armstrong, Deborah Ashby, Katie J Bayfield, Diana Bilton, Emily V Bloomfield, A Christopher Boyd, June Brand, Ruaridh Buchan, Roberto Calcedo, Paula Carvelli, Mario Chan, Seng H Cheng, David S Collie, Steve Cunningham, Heather E Davidson, Gwyneth Davies, Jane C Davies, Lee A Davies, Maria H Dewar, Ann Doherty, Jackie Donovan, Natalie S Dwyer, Hala I Elgmati, Rosanna F Featherstone, Jemyr Gavino, Sabrina Gea-Sorli, Duncan M Geddes, James SR Gibson, Deborah R Gill, Andrew P Greening, Uta Griesenbach, David M Hansell, Katharine Harman, Tracy E Higgins, Samantha L Hodges, Stephen C Hyde, Laura Hyndman, J Alastair Innes, Joseph Jacob, Nancy Jones, Brian F Keogh, Maria P Limberis, Paul Lloyd-Evans, Alan W Maclean, Michelle C Manvell, Dominique McCormick, Michael McGovern, Gerry McLachlan, Cuixiang Meng, M Angeles Montero, Hazel Milligan, Laura J Moyce, Gordon D Murray, Andrew G Nicholson, Tina Osadolor, Javier Parra-Leiton, David J Porteous, Ian A Pringle, Emma K Punch, Kamila M Pytel, Alexandra L Quittner, Gina Rivellini, Clare J Saunders, Ronald K Scheule, Sarah Sheard, Nicholas J Simmonds, Keith Smith, Stephen N Smith, Najwa Soussi, Samia Soussi, Emma J Spearing, Barbara J Stevenson, Stephanie G Sumner-Jones, Minna Turkkila, Rosa P Ureta, Michael D Waller, Marguerite Y Wasowicz, James M Wilson, Paul Wolstenholme-Hogg, on behalf of the UK Cystic Fibrosis Gene Therapy Consortium

Publikováno v: Efficacy and Mechanism Evaluation, Vol 3, Iss 5 (2016)

Background: Cystic fibrosis (CF) is a chronic, life-limiting disease caused by mutations in the CF transmembrane conductance regulator (CFTR) gene leading to abnormal airway surface ion transport, chronic lung infections, inflammation and eventual re

Externí odkaz: https://doaj.org/article/09b29fe1b155492fba24a177fe4be24c

Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.

Fiber-Optic Network Observations of Earthquake Wavefields

Autor: Lindsey, NJ, Martin, ER, Dreger, DS, Freifeld, B, Cole, S, James, SR, Biondi, BL, Ajo-Franklin, JB

Publikováno v: Geophysical Research Letters, vol 44, iss 23
Lindsey, NJ; Martin, ER; Dreger, DS; Freifeld, B; Cole, S; James, SR; et al.(2017). Fiber-Optic Network Observations of Earthquake Wavefields. Geophysical Research Letters, 44(23), 11-799. doi: 10.1002/2017GL075722. Lawrence Berkeley National Laboratory: Retrieved from: http://www.escholarship.org/uc/item/4q12j9t1

©2017. American Geophysical Union. All Rights Reserved. Our understanding of subsurface processes suffers from a profound observation bias: seismometers are sparse and clustered on continents. A new seismic recording approach, distributed acoustic s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::400e06c393b9e463aea86487d66f8c6d
https://escholarship.org/uc/item/4q12j9t1

A randomised, double-blind, placebo-controlled trial of repeated nebulisation of non-viral cystic fibrosis transmembrane conductance regulator (CFTR) gene therapy in patients with cystic fibrosis

Autor: Alton, Eric Wfw, Armstrong, David K, Ashby, Deborah, Bayfield, Katie J, Bilton, Diana, Bloomfield, Emily V, Boyd, A Christopher, Brand, June, Buchan, Ruaridh, Calcedo, Roberto, Carvelli, Paula, Chan, Mario, Cheng, Seng H, Collie, David S, Cunningham, Steve, Davidson, Heather E, Davies, Gwyneth, Davies, Jane C, Davies, Lee A, Dewar, Maria H, Doherty, Ann, Donovan, Jackie, Dwyer, Natalie S, Elgmati, Hala I, Featherstone, Rosanna F, Gavino, Jemyr, Gea-sorli, Sabrina, Geddes, Duncan M, Gibson, James Sr, Gill, Deborah R, Greening, Andrew P, Griesenbach, Uta, Hansell, David M, Harman, Katharine, Higgins, Tracy E, Hodges, Samantha L, Hyde, Stephen C, Hyndman, Laura, Innes, J Alastair, Jacob, Joseph, Jones, Nancy, Keogh, Brian F, Limberis, Maria P, Lloyd-evans, Paul, Maclean, Alan W, Manvell, Michelle C, Mccormick, Dominique, Mcgovern, Michael, Mclachlan, Gerry, Meng, Cuixiang, Montero, M Angeles, Milligan, Hazel, Moyce, Laura J, Murray, Gordon D, Nicholson, Andrew G, Osadolor, Tina, Parra-leiton, Javier, Porteous, David J, Pringle, Ian A, Punch, Emma K, Pytel, Kamila M, Quittner, Alexandra L, Rivellini, Gina, Saunders, Clare J, Scheule, Ronald K, Sheard, Sarah, Simmonds, Nicholas J, Smith, Keith, Smith, Stephen N, Soussi, Najwa, Soussi, Samia, Spearing, Emma J, Stevenson, Barbara J, Sumner-jones, Stephanie G, Turkkila, Minna, Ureta, Rosa P, Waller, Michael D, Wasowicz, Marguerite Y, Wilson, James M, Wolstenholme-hogg, Paul

Publikováno v: Alton, E W, Armstrong, D K, Ashby, D, Bayfield, K J, Bilton, D, Bloomfield, E V, Boyd, A C, Brand, J, Buchan, R, Calcedo, R, Carvelli, P, Chan, M, Cheng, S H, Collie, D S, Cunningham, S, Davidson, H E, Davies, G, Davies, J C, Davies, L A, Dewar, M H, Doherty, A, Donovan, J, Dwyer, N S, Elgmati, H I, Featherstone, R F, Gavino, J, Gea-sorli, S, Geddes, D M, Gibson, J S, Gill, D R, Greening, A P, Griesenbach, U, Hansell, D M, Harman, K, Higgins, T E, Hodges, S L, Hyde, S C, Hyndman, L, Innes, J A, Jacob, J, Jones, N, Keogh, B F, Limberis, M P, Lloyd-evans, P, Maclean, A W, Manvell, M C, Mccormick, D, Mcgovern, M, Mclachlan, G, Meng, C, Montero, M A, Milligan, H, Moyce, L J, Murray, G D, Nicholson, A G, Osadolor, T, Parra-leiton, J, Porteous, D J, Pringle, I A, Punch, E K, Pytel, K M, Quittner, A L, Rivellini, G, Saunders, C J, Scheule, R K, Sheard, S, Simmonds, N J, Smith, K, Smith, S N, Soussi, N, Soussi, S, Spearing, E J, Stevenson, B J, Sumner-jones, S G, Turkkila, M, Ureta, R P, Waller, M D, Wasowicz, M Y, Wilson, J M & Wolstenholme-hogg, P 2016, A randomised, double-blind, placebo-controlled trial of repeated nebulisation of non-viral cystic fibrosis transmembrane conductance regulator (CFTR) gene therapy in patients with cystic fibrosis . Efficacy and Mechanism Evaluation, no. 5, vol. 3, vol. 3 . https://doi.org/10.3310/eme03050

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______3094::652d7f6547305ca5fd120989d6732d40
https://hdl.handle.net/20.500.11820/6cbd29f1-9d74-4a71-a11a-6d87edad87e6

Changes in physiological, functional and structural markers of cystic fibrosis lung disease with treatment of a pulmonary exacerbation

Autor: Maria H Dewar, Ann Doherty, Clare Saunders, Mark G. Meister, Alex Horsley, Jane C. Davies, Andrew P. Greening, Samia Soussi, Yusura Bakar, N.J. Bell, Sarah Jeswiet, Javier Parra-Leiton, J. Alastair Innes, N. Voase, Deborah Ashby, David M. Hansell, Stephen C. Hyde, Zelena A. Aziz, Kenneth A Macleod, Deborah R. Gill, Mia D.B. Larsen, Shahrul Mt-Isa, Steve Cunningham, David J. Porteous, Uta Griesenbach, James Sr Gibson, Eric W.F.W. Alton, Margaret Rainer, Jackie Donovan, A. Christopher Boyd, Robert D. Gray, Philippa Tyler

Publikováno v: Thorax. 68(6)

BACKGROUND: Clinical trials in cystic fibrosis (CF) have been hindered by the paucity of well characterised and clinically relevant outcome measures. AIM: To evaluate a range of conventional and novel biomarkers of CF lung disease in a multicentre se

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d24f90246e33330256ac4ec7020e98ac
http://ora.ox.ac.uk/objects/uuid:df8d67e9-d5c5-458f-8955-b69a05397536