Zobrazeno 1 - 10
of 42
pro vyhledávání: '"James, McColl"'
Autor:
Edward Jenkins, Markus Körbel, Caitlin O’Brien-Ball, James McColl, Kevin Y. Chen, Mateusz Kotowski, Jane Humphrey, Anna H. Lippert, Heather Brouwer, Ana Mafalda Santos, Steven F. Lee, Simon J. Davis, David Klenerman
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-21 (2023)
T cells can use TCR on microvilli to interact with peptide-MHC (pMHC) complexes on antigen presenting cells. Here the authors characterise how T cells use microvilli to interrogate reconstituted membranes for pMHC complexes and how this is regulated
Externí odkaz:
https://doaj.org/article/e163cebf0d034cc0b49fca7e959be290
Autor:
James McColl, David Klenerman
Publikováno v:
The Immune Synapse ISBN: 9781071631348
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::277861dfe8da9e21471ac4b3febefeae
https://doi.org/10.1007/978-1-0716-3135-5_3
https://doi.org/10.1007/978-1-0716-3135-5_3
Autor:
Edward Jenkins, Simon J. Davis, David Klenerman, Jane Humphrey, Ana Filipa L.O.M. Santos, Ivan B Dimov, James McColl, Alexander K. Winkel, Anna Lippert, Kevin Y. Chen, Kristian Franze
Publikováno v:
Biophysical Journal
Much of what we know about the early stages of T cell activation has been obtained from studies of T cells interacting with glass-supported lipid bilayers that favor imaging but are orders of magnitude stiffer than typical cells. We developed a metho
Autor:
Laura Weimann, Kristina A Ganzinger, James McColl, Kate L Irvine, Simon J Davis, Nicholas J Gay, Clare E Bryant, David Klenerman
Publikováno v:
PLoS ONE, Vol 8, Iss 5, p e64287 (2013)
Single-particle tracking (SPT) is widely used to study processes from membrane receptor organization to the dynamics of RNAs in living cells. While single-dye labeling strategies have the benefit of being minimally invasive, this comes at the expense
Externí odkaz:
https://doaj.org/article/4320fa141aa94701811e0dd120cf10e0
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2179
Avian (chick) embryos are an established and accessible model organism making them ideal for studying developmental processes. Chick embryos can be harvested from the egg and cultured allowing real-time observations and imaging. Here, we describe ex
Publikováno v:
Methods in Molecular Biology ISBN: 9781071607787
Avian (chick) embryos are an established and accessible model organism making them ideal for studying developmental processes. Chick embryos can be harvested from the egg and cultured allowing real-time observations and imaging. Here, we describe ex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b4fa234a82e63f5c63865b185ca77483
https://doi.org/10.1007/978-1-0716-0779-4_15
https://doi.org/10.1007/978-1-0716-0779-4_15
Autor:
Lisa-Maria Needham, Steven F. Lee, Simon J. Davis, Ricardo Henriques, Christophe Leterrier, Ana Filipa L.O.M. Santos, James McColl, Anoushka Handa, Alexander R. Carr, Aleks Ponjavic, Daniel Esteban-Ferrer, Alexandre Kitching, Alexander Spark
Publikováno v:
Nat Methods
Nature Methods
Nature Methods, Nature Publishing Group, 2020, ⟨10.1038/s41592-020-0962-1⟩
Nature Methods, 2020, ⟨10.1038/s41592-020-0962-1⟩
Nature Methods
Nature Methods, Nature Publishing Group, 2020, ⟨10.1038/s41592-020-0962-1⟩
Nature Methods, 2020, ⟨10.1038/s41592-020-0962-1⟩
International audience; vLUME is a virtual reality software package designed to render large three-dimensional single-molecule localization micros-copy datasets. vLUME features include visualization, seg-mentation, bespoke analysis of complex local g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a90f64dd13cff826b00e76282596d309
Autor:
Edward Jenkins, Ivan B Dimov, Kevin Y. Chen, Simon J. Davis, David Klenerman, Alexander K. Winkel, Anna Lippert, Jane Humphrey, Ana Filipa L.O.M. Santos, James McColl, Kristian Franze
The T-cell receptor (TCR) is thought to be triggered either by mechano-transduction or local tyrosine phosphatase exclusion at cell-cell contacts. However, the effects of the mechanical properties of activating surfaces have only been tested for late
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d0d00e8a03e37e6cfa4223c44f47a614
https://doi.org/10.1101/2020.06.05.134684
https://doi.org/10.1101/2020.06.05.134684
Autor:
Alexander K. Winkel, Simon J. Davis, David Klenerman, Steven F. Lee, Edward Jenkins, Aleks Ponjavic, Anna Lippert, Klara Kulenkampff, Jane Humphrey, Ana Filipa L.O.M. Santos, Kristian Franze, James McColl
Publikováno v:
BASE-Bielefeld Academic Search Engine
Biophysical Journal
Biophysical Journal
Cell-cell contacts often underpin signaling between cells. For immunology, the binding of a T cell receptor to an antigen-presenting pMHC initiates downstream signaling and an immune response. Although this contact is mediated by proteins on both cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de3cd88fe46690c89a7df2d877643cdc
Autor:
David Lando, Ulrike Endesfelder, Harald Berger, Lakxmi Subramanian, Paul D. Dunne, James McColl, David Klenerman, Antony M. Carr, Markus Sauer, Robin C. Allshire, Mike Heilemann, Ernest D. Laue
Publikováno v:
Open Biology, Vol 2, Iss 7 (2012)
The inheritance of the histone H3 variant CENP-A in nucleosomes at centromeres following DNA replication is mediated by an epigenetic mechanism. To understand the process of epigenetic inheritance, or propagation of histones and histone variants, as
Externí odkaz:
https://doaj.org/article/d4434d82101348dfb7371e24d1b3bdca