Zobrazeno 1 - 10
of 809
pro vyhledávání: '"James, Larkin"'
Autor:
Richard Culliford, Samuel E. D. Lawrence, Charlie Mills, Zayd Tippu, Daniel Chubb, Alex J. Cornish, Lisa Browning, Ben Kinnersley, Robert Bentham, Amit Sud, Husayn Pallikonda, The Renal Cancer Genomics England Consortium, Anna Frangou, Andreas J. Gruber, Kevin Litchfield, David Wedge, James Larkin, Samra Turajlic, Richard S. Houlston
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Clear cell renal cell carcinoma (ccRCC) is the most common form of kidney cancer, but a comprehensive description of its genomic landscape is lacking. We report the whole genome sequencing of 778 ccRCC patients enrolled in the 100,000 Genome
Externí odkaz:
https://doaj.org/article/25c1fd274e444b1a83a98b4d7c16c2c8
Autor:
Mélissa Mialon, James Larkin, Clare Patton, Mimi Tatlow-Golden, Kathryn Reilly, Paula Leonard, Malvina Walsh, Norah Campbell
Publikováno v:
BJGP Open, Vol 8, Iss 2 (2024)
Externí odkaz:
https://doaj.org/article/5a84e97d2db5469f97ab23cebbe488e8
Autor:
Nick Powell, Mark R Thursz, Kevin J Woollard, James Larkin, Samra Turajlic, Stephen R Atkinson, Robert D Goldin, Evangelos Triantafyllou, Lucia A Possamai, Charalambos G Antoniades, Cathrin L C Gudd, Eoin Mitchell, Marie-Anne Mawhin
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 12, Iss 4 (2024)
Background Checkpoint inhibitor-induced hepatitis (CPI-hepatitis) is an emerging problem with the widening use of CPIs in cancer immunotherapy. Here, we developed a mouse model to characterize the mechanism of CPI-hepatitis and to therapeutically tar
Externí odkaz:
https://doaj.org/article/ef7d49df3e824b6ba015b5adda0e950e
Autor:
Rene van Tienhoven, Diahann T. S. L. Jansen, Miso Park, John C. Williams, James Larkin, Sergio A. Quezada, Bart O. Roep
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionThe autoimmune response in type 1 diabetes (T1D), in which the beta cells expressing aberrant or modified proteins are killed, resembles an effective antitumor response. Defective ribosomal protein products in tumors are targets of the an
Externí odkaz:
https://doaj.org/article/75386fe00e12430880c10e6752c5be13
Autor:
Muirne Spooner, James Larkin, Siaw Cheok Liew, Mohamed Hasif Jaafar, Samuel McConkey, Teresa Pawlikowska
Publikováno v:
BMC Medical Education, Vol 23, Iss 1, Pp 1-11 (2023)
Abstract Introduction While feedback aims to support learning, students frequently struggle to use it. In studying feedback responses there is a gap in explaining them in relation to learning theory. This study explores how feedback experiences influ
Externí odkaz:
https://doaj.org/article/79b2db79e7d3480f831e76ed2c322844
Autor:
Maria Pierce, Louise Foley, Bridget Kiely, Aisling Croke, James Larkin, Susan M. Smith, Barbara Clyne, Edel Murphy
Publikováno v:
Research Involvement and Engagement, Vol 9, Iss 1, Pp 1-22 (2023)
Abstract Background Incorporating Public and Patient Involvement (PPI) into doctoral research is valued by PhD funders and scholars. Providing early career researchers with appropriate training to develop skills to conduct meaningful PPI involvement
Externí odkaz:
https://doaj.org/article/275013921d564d4dba5544b99f6f6568
Autor:
Matthew R. Orton, Evan Hann, Simon J. Doran, Scott T. C. Shepherd, Derfel Ap Dafydd, Charlotte E. Spencer, José I. López, Víctor Albarrán-Artahona, Francesca Comito, Hannah Warren, Joshua Shur, Christina Messiou, James Larkin, Samra Turajlic, on behalf of the TRACERx Renal Consortium, Dow-Mu Koh
Publikováno v:
Cancer Imaging, Vol 23, Iss 1, Pp 1-14 (2023)
Abstract Background The aim of this work is to evaluate the performance of radiomics predictions for a range of molecular, genomic and clinical targets in patients with clear cell renal cell carcinoma (ccRCC) and demonstrate the impact of novel featu
Externí odkaz:
https://doaj.org/article/776e2f4a16584d99afb2c139c1ffe7f5
Autor:
James Larkin, Harriet Kluger, Omid Hamid, Jeffrey Weber, Amod A Sarnaik, Brian Gastman, Jeffrey Chou, John M Kirkwood, Eric Whitman, Martin Wermke, Evidio Domingo-Musibay, Theresa Medina, Sajeve Thomas, Wen Shi, Xiao Wu, Jason A Chesney, Giri Sulur, Friedrich Graf Finckenstein
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)
Externí odkaz:
https://doaj.org/article/dd15fbf338ed45b1a76ce053944ef9df
Autor:
Gino K In, James Larkin, Yazan Samhouri, Marcus Butler, Victoria Atkinson, Jeffrey Chou, Juan Martin-Liberal, Patrick Terheyden, Sajeve Thomas, Wen Shi, Xiao Wu, Andrew S Poklepovic, Young Hong, Giri Sulur, Friedrich Graf Finckenstein, John B Haanen, Andrew JS Furness, Philip Lammers, Ryan H Nguyen, Idit Peretz
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)
Externí odkaz:
https://doaj.org/article/e9124cbb47384a959e3a6d05d13868b4
Autor:
Sebastian Bauer, James Larkin, F. Stephen Hodi, Frank Stephen, Ellen H. W. Kapiteijn, Gary K. Schwartz, Emilano Calvo, Padmaja Yerramilli-Rao, Sophie Piperno-Neumann, Richard D. Carvajal
Publikováno v:
Frontiers in Oncology, Vol 12 (2023)
BackgroundUveal melanoma is a disease characterized by constitutive activation of the G alpha pathway and downstream signaling of protein kinase C (PKC) and the mitogen-activated protein kinase (MAPK) pathway. While limited clinical activity has been
Externí odkaz:
https://doaj.org/article/333ba02eee294c13b68620231919623d