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Akademický článek

Identification of recent cases of hepatitis C virus infection using physical-chemical properties of hypervariable region 1 and a radial basis function neural network classifier

Autor: James Lara, Mahder Teka, Yury Khudyakov

Publikováno v: BMC Genomics, Vol 18, Iss S10, Pp 33-42 (2017)

Abstract Background Identification of acute or recent hepatitis C virus (HCV) infections is important for detecting outbreaks and devising timely public health interventions for interruption of transmission. Epidemiological investigations and chemist

Externí odkaz: https://doaj.org/article/3a03595efd07433c91008df43212501a

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Akademický článek

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Akademický článek

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Periodical

Development of the Methodology for in SilicoReactivity-Based Purge Predictions: Making Mirabilis Think Like a Chemist

Autor: McManus, James A., Lopez-Rodríguez, Rocío, Murphy, Natasha S., James, Lara, O’Connor, Daniel C., Gavins, Georgina C., Burns, Michael J.

Publikováno v: Organic Process Research & Development; October 2023, Vol. 27 Issue: 10 p1773-1783, 11p

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Periodical

Identifying the Risk of Formation of Nitrosamines and Other Potentially Mutagenic Impurities during API Manufacture Using In SilicoRisk Assessment

Autor: Murphy, Natasha S., O’Connor, Daniel C., Gavins, Georgina C., James, Lara, Lockett, Jonathan P., McManus, James A., Packer, Gemma, Lopez-Rodríguez, Rocío, Webb, Samuel J., Burns, Michael J.

Publikováno v: Organic Process Research & Development; October 2023, Vol. 27 Issue: 10 p1812-1819, 8p

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Quantitative differences between intra-host HCV populations from persons with recently established and persistent infections

Autor: Yury Khudyakov, Pavel Skums, James Lara, Pelin Icer Baykal, Alexander Zelikovsky

Publikováno v: Virus Evolution

SummaryBackgroundDetection of incident hepatitis C virus (HCV) infections is crucial for identification of outbreaks and development of public health interventions. However, there is no single diagnostic assay for distinguishing recent and persistent

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6e4f71c094fb5b029d1f99aadba98bd
https://doi.org/10.1093/ve/veaa103

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Complex genetic encoding of the hepatitis B virus on-drug persistence

Autor: James Lara, Lilia Ganova-Raeva, Guo-liang Xia, Hong Thai, Kathryn M. Kitrinos, Henry Lik-Yuen Chan, Yury Khudyakov, Anuj Gaggar, Xiao-Jun Xu

Publikováno v: Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)

Tenofovir disoproxil fumarate (TDF) is one of the nucleotide analogs capable of inhibiting the reverse transcriptase (RT) activity of HIV and hepatitis B virus (HBV). There is no known HBV resistance to TDF. However, detectable variation in duration

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::150c11e259124acb129c733ba2011cdc
https://pubmed.ncbi.nlm.nih.gov/32968103

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Akademický článek

The hepatitis E virus polyproline region is involved in viral adaptation.

Autor: Michael A Purdy, James Lara, Yury E Khudyakov

Publikováno v: PLoS ONE, Vol 7, Iss 4, p e35974 (2012)

Genomes of hepatitis E virus (HEV), rubivirus and cutthroat virus (CTV) contain a region of high proline density and low amino acid (aa) complexity, named the polyproline region (PPR). In HEV genotypes 1, 3 and 4, it is the only region within the non

Externí odkaz: https://doaj.org/article/b7f3daf801c745589c6761d3a2172850

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