Výsledky vyhledávání - "James, K. T."

Osteoporosis identification among previously undiagnosed individuals with vertebral fractures

Autor: Gold, L. S., Cody, R. F., Tan, W. K., Marcum, Z. A., Meier, E. N., Sherman, K. J., James, K. T., Griffith, B., Avins, A. L., Kallmes, D. F., Suri, P., Friedly, J. L., Heagerty, P. J., Deyo, R. A., Luetmer, P. H., Rundell, S. D., Haynor, D. R., Jarvik, J. G.

Publikováno v: Osteoporos Int

Because osteoporosis is under-recognized in patients with vertebral fractures, we evaluated characteristics associated with osteoporosis identification. Most patients with vertebral fractures did not receive evaluation or treatment for osteoporosis.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::060be2f8bd690c325c7540804872d0dd
https://doi.org/10.1007/s00198-022-06450-7

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Akademický článek

Cardiac Glycosides Provide Neuroprotection against Ischemic Stroke: Discovery by a Brain Slice-Based Compound Screening Platform

Autor: Wang, James K. T., Portbury, Stuart, Thomas, Mary Beth, Barney, Shawn, Ricca, Daniel J., Morris, Dexter L., Warner, David S., Lo, Donald C.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America, 2006 Jul 01. 103(27), 10461-10466.

Externí odkaz: https://www.jstor.org/stable/30049646

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Uniting homeostatic plasticity and exosome biology: A revision of the conceptual framework for drug discovery in neurodegenerative diseases?

Autor: James K T, Wang

Publikováno v: Advances in pharmacology (San Diego, Calif.). 90

Neurodegenerative diseases (NDDs) are in need of new drug discovery approaches. Our previous systematic analyses of Huntington's Disease (HD) literature for protein-protein interactors (PPIs) and modifiers of mutant Huntingtin-driven phenotypes revea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::39261c30ea0ec8083236c287a6bf38fb
https://pubmed.ncbi.nlm.nih.gov/33706937

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Uniting homeostatic plasticity and exosome biology: A revision of the conceptual framework for drug discovery in neurodegenerative diseases?

Autor: James K T Wang

Publikováno v: A Tribute to Paul Greengard (1925-2019) ISBN: 9780128225165

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::32014bd0fc0100333f1d61cba00072df
https://doi.org/10.1016/bs.apha.2020.10.002

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Exosomes and Homeostatic Synaptic Plasticity Are Linked to Each other and to Huntington's, Parkinson's, and Other Neurodegenerative Diseases by Database-Enabled Analyses of Comprehensively Curated Datasets

Autor: Palazzolo Michael J, James K. T. Wang, Steve Horvath, Peter Langfelder

Publikováno v: Frontiers in neuroscience, vol 11, iss MAR
Frontiers in Neuroscience

Huntington's disease (HD) is a progressive and autosomal dominant neurodegeneration caused by CAG expansion in the huntingtin gene (HTT), but the pathophysiological mechanism of mutant HTT (mHTT) remains unclear. To study HD using systems biological

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::394cc62d2020e4d312a3f2c69cbb6acf
https://escholarship.org/uc/item/6xt5s5sb

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Neurotrophin-3 mediates the autocrine survival of the catecholaminergic CAD CNS neuronal cell line

Autor: James K. T. Wang, Dona M. Chikaraishi, Cheryl D. Horton, Yanping Qi

Publikováno v: Journal of Neurochemistry. 76:201-209

The mechanisms for neuronal survival in the CNS are not well understood, but are likely to be complex due to possible autocrine and redundant neurotrophic support. Most studies have focused on the nerve growth factor (NGF)/TrkA pathway in peripheral

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6e797a75f9c80595f4d5f118b174c45c
https://doi.org/10.1046/j.1471-4159.2001.00017.x

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Vasodilator-stimulated phosphoprotein (VASP) is phosphorylated on Ser157 by protein kinase C-dependent and -independent mechanisms in thrombin-stimulated human platelets

Autor: James K. T. Wentworth, Giordano Pula, Alastair W. Poole

Publikováno v: Biochemical Journal. 393:555-564

VASP (vasodilator-stimulated phosphoprotein) is an actin- and profilin-binding protein that is expressed in platelets at high levels and plays a major role in negatively regulating secretory and adhesive events in these cells. VASP is a major substra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fcab477ac957885370fcdcc20145e366
https://doi.org/10.1042/bj20050796

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Heterologous sensitization of adenylate cyclase is protein kinase A-dependent in Cath.a differentiated (CAD)-D2L cells

Autor: Michael A. Beazely, Val J. Watts, Christopher A. Johnston, James K. T. Wang, Amanda F. Vancura

Publikováno v: Journal of Neurochemistry. 82:1087-1096

Persistent activation of Gαi/o-coupled receptors results in a paradoxical enhancement of subsequent drug-stimulated adenylate cyclase activity. The exact mechanism of this up-regulation in the cyclic AMP signaling pathway, known as heterologous sens

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fb0dc9939b81cfeff6e96d32c154cd9c
https://doi.org/10.1046/j.1471-4159.2002.01033.x

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