Zobrazeno 1 - 10
of 28
pro vyhledávání: '"James, Hair"'
Publikováno v:
SLAS Discovery, Vol 27, Iss 2, Pp 95-106 (2022)
The field of Immuno-Oncology (IO) is evolving to utilise novel antibody backbones that can co-target multiple cell-surface stimulatory and inhibitory co-receptors (SICR). This approach necessitates a better understanding of SICR co-expression at the
Externí odkaz:
https://doaj.org/article/9087a34ea27f4b3ea19c5bd2348d173a
Autor:
Scott A. Hammond, Andrew Weinberg, Nicholas P. Morris, Louis Picker, Michael K. Axthelm, Andrew Sylwester, Haesun Park, Andrew J. Pierce, Lolke de Haan, Nicholas Buss, Steven Eck, Hui Feng, Melissa Damschroder, Qun Du, Shino Hanabuchi, James Hair, Kelly McGlinchey, Kathy Mulgrew, Stacy Kentner, Chad Morris, Catherine Augé, Michael D. Oberst
Expression of cell surface Fc gamma receptors on human cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::123f7d8216dfd0b1f3ce6f1f64cd89ab
https://doi.org/10.1158/1535-7163.22505539.v1
https://doi.org/10.1158/1535-7163.22505539.v1
Autor:
Yariv Mazor, Robert W. Wilkinson, Daniel J. Freeman, Ikbel Achour, William Dall'Acqua, Aleksandra D. Toloczko, Thomas V. Murray, Frances Neal, Gareth J. Browne, Godfrey J. Rainey, Michelle Morrow, Asis Palazon, Yanli Wu, James Dodgson, Michael G. Overstreet, Yaya Wang, Kathy Mulgrew, Stacy Kentner, Xiaofang Jin, Arthur Lewis, Kapil Vashisht, Shelby D. Gainer, Deepa S. Subramaniam, Ben Tran, Seock-Ah Im, Bo Wang, Sumati Hasani, Des C. Jones, James Hair, Anna Hansen, Lorraine Irving, Suzanne I. Sitnikova, Chunning Yang, Matthew J. Elder, Simon J. Dovedi
Supplementary Materials and Methods, and Supplementary Figures
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::238b4ab5c831dd6063dffdf564c8ad3c
https://doi.org/10.1158/2159-8290.22540037
https://doi.org/10.1158/2159-8290.22540037
Autor:
Scott A. Hammond, Andrew Weinberg, Nicholas P. Morris, Louis Picker, Michael K. Axthelm, Andrew Sylwester, Haesun Park, Andrew J. Pierce, Lolke de Haan, Nicholas Buss, Steven Eck, Hui Feng, Melissa Damschroder, Qun Du, Shino Hanabuchi, James Hair, Kelly McGlinchey, Kathy Mulgrew, Stacy Kentner, Chad Morris, Catherine Augé, Michael D. Oberst
Supplementary Methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae534900ee576be4839bebdf0965290a
https://doi.org/10.1158/1535-7163.22505521
https://doi.org/10.1158/1535-7163.22505521
Autor:
Scott A. Hammond, Andrew Weinberg, Nicholas P. Morris, Louis Picker, Michael K. Axthelm, Andrew Sylwester, Haesun Park, Andrew J. Pierce, Lolke de Haan, Nicholas Buss, Steven Eck, Hui Feng, Melissa Damschroder, Qun Du, Shino Hanabuchi, James Hair, Kelly McGlinchey, Kathy Mulgrew, Stacy Kentner, Chad Morris, Catherine Augé, Michael D. Oberst
Ligation of OX40 (CD134, TNFRSF4) on activated T cells by its natural ligand (OX40L, CD252, TNFSF4) enhances cellular survival, proliferation, and effector functions such as cytokine release and cellular cytotoxicity. We engineered a recombinant huma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b9055300403acf6ff9ac96ec905dac3f
https://doi.org/10.1158/1535-7163.c.6538102.v1
https://doi.org/10.1158/1535-7163.c.6538102.v1
Autor:
Yariv Mazor, Robert W. Wilkinson, Daniel J. Freeman, Ikbel Achour, William Dall'Acqua, Aleksandra D. Toloczko, Thomas V. Murray, Frances Neal, Gareth J. Browne, Godfrey J. Rainey, Michelle Morrow, Asis Palazon, Yanli Wu, James Dodgson, Michael G. Overstreet, Yaya Wang, Kathy Mulgrew, Stacy Kentner, Xiaofang Jin, Arthur Lewis, Kapil Vashisht, Shelby D. Gainer, Deepa S. Subramaniam, Ben Tran, Seock-Ah Im, Bo Wang, Sumati Hasani, Des C. Jones, James Hair, Anna Hansen, Lorraine Irving, Suzanne I. Sitnikova, Chunning Yang, Matthew J. Elder, Simon J. Dovedi
The clinical benefit of PD-1 blockade can be improved by combination with CTLA4 inhibition but is commensurate with significant immune-related adverse events suboptimally limiting the doses of anti-CTLA4 mAb that can be used. MEDI5752 is a monovalent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ca7eaed273b219faf1bb63ec9cf8694
https://doi.org/10.1158/2159-8290.c.6549263
https://doi.org/10.1158/2159-8290.c.6549263
Autor:
Scott A. Hammond, Andrew Weinberg, Nicholas P. Morris, Louis Picker, Michael K. Axthelm, Andrew Sylwester, Haesun Park, Andrew J. Pierce, Lolke de Haan, Nicholas Buss, Steven Eck, Hui Feng, Melissa Damschroder, Qun Du, Shino Hanabuchi, James Hair, Kelly McGlinchey, Kathy Mulgrew, Stacy Kentner, Chad Morris, Catherine Augé, Michael D. Oberst
Supplementary Figure 5. Lack of NK cell mediated ADCC and complement protein C1q binding by MEDI6383. Supplementary Figure 6. MEDI6383 mediated release of cytokines from primary human T cells.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db041ff2d652c7052f608239ed819b86
https://doi.org/10.1158/1535-7163.22505527.v1
https://doi.org/10.1158/1535-7163.22505527.v1
Autor:
Natalie J. Tigue, Lisa Bamber, John Andrews, Samantha Ireland, James Hair, Edward Carter, Sudharsan Sridharan, Jelena Jovanović, D. Gareth Rees, Jeremy S. Springall, Emilie Solier, Yi-Ming Li, Matthieu Chodorge, David Perez-Martinez, Daniel R. Higazi, Michael Oberst, Maureen Kennedy, Chelsea M. Black, Li Yan, Martin Schwickart, Shaun Maguire, Jennifer A. Cann, Lolke de Haan, Lesley L. Young, Tristan Vaughan, Robert W. Wilkinson, Ross Stewart
Publikováno v:
OncoImmunology, Vol 6, Iss 3 (2017)
Glucocorticoid-induced tumor necrosis factor receptor-related protein (GITR) is part of a system of signals involved in controlling T-cell activation. Targeting and agonizing GITR in mice promotes antitumor immunity by enhancing the function of effec
Externí odkaz:
https://doaj.org/article/2ce1d1f11ec645bc9ff9055a90e162ac
Autor:
Bo Wang, Frances Neal, Arthur Lewis, Kapil Vashisht, Deepa S. Subramaniam, Des C. Jones, Sumati Hasani, Daniel J. Freeman, Chunning Yang, Lorraine Irving, Michael G. Overstreet, Gareth J. Browne, Suzanne I. Sitnikova, James Hair, Robert W. Wilkinson, Yaya Wang, Ben Tran, Ikbel Achour, James Dodgson, Shelby D. Gainer, Xiaofang Jin, Seock-Ah Im, William F Dall'Acqua, Yariv Mazor, Godfrey Rainey, Asis Palazon, Anna Hansen, Yanli Wu, Matthew J. Elder, Stacy Kentner, Aleksandra D. Toloczko, Michelle Morrow, Murray Thomas Vincent, Simon J. Dovedi, Kathy Mulgrew
Publikováno v:
Cancer Discovery. 11:1100-1117
The clinical benefit of PD-1 blockade can be improved by combination with CTLA4 inhibition but is commensurate with significant immune-related adverse events suboptimally limiting the doses of anti-CTLA4 mAb that can be used. MEDI5752 is a monovalent
Autor:
Simon J, Dovedi, Matthew J, Elder, Chunning, Yang, Suzanne I, Sitnikova, Lorraine, Irving, Anna, Hansen, James, Hair, Des C, Jones, Sumati, Hasani, Bo, Wang, Seock-Ah, Im, Ben, Tran, Deepa S, Subramaniam, Shelby D, Gainer, Kapil, Vashisht, Arthur, Lewis, Xiaofang, Jin, Stacy, Kentner, Kathy, Mulgrew, Yaya, Wang, Michael G, Overstreet, James, Dodgson, Yanli, Wu, Asis, Palazon, Michelle, Morrow, Godfrey J, Rainey, Gareth J, Browne, Frances, Neal, Thomas V, Murray, Aleksandra D, Toloczko, William, Dall'Acqua, Ikbel, Achour, Daniel J, Freeman, Robert W, Wilkinson, Yariv, Mazor
Publikováno v:
Cancer discovery. 11(5)
The clinical benefit of PD-1 blockade can be improved by combination with CTLA4 inhibition but is commensurate with significant immune-related adverse events suboptimally limiting the doses of anti-CTLA4 mAb that can be used. MEDI5752 is a monovalent