Zobrazeno 1 - 10
of 17
pro vyhledávání: '"James, Finke"'
Autor:
Jill W. Ford, Marieli Gonzalez-Cotto, Alexander W. MacFarlane, Suraj Peri, O. M. Zack Howard, Jeffrey J. Subleski, Karen J. Ruth, Mohammed Haseebuddin, Tahseen Al-Saleem, Youfeng Yang, Pat Rayman, Brian Rini, W. Marston Linehan, James Finke, Jonathan M. Weiss, Kerry S. Campbell, Daniel W. McVicar
Publikováno v:
Frontiers in Oncology, Vol 11 (2022)
Myeloid-derived suppressor cells (MDSC) and tumor-associated macrophages (TAM) contribute to cancer-related inflammation and tumor progression. While several myeloid molecules have been ascribed a regulatory function in these processes, the triggerin
Externí odkaz:
https://doaj.org/article/b29a1d769f3c4074858d8da7e828b13c
Autor:
Jill W. Ford, Marieli Gonzalez-Cotto, Alexander W. MacFarlane, Suraj Peri, O. M. Zack Howard, Jeffrey J. Subleski, Karen J. Ruth, Mohammed Haseebuddin, Tahseen Al-Saleem, Youfeng Yang, Pat Rayman, Brian Rini, W. Marston Linehan, James Finke, Jonathan M. Weiss, Kerry S. Campbell, Daniel W. McVicar
Publikováno v:
Frontiers in Oncology, Vol 11 (2022)
Myeloid-derived suppressor cells (MDSC) and tumor-associated macrophages (TAM) contribute to cancer-related inflammation and tumor progression. While several myeloid molecules have been ascribed a regulatory function in these processes, the triggerin
Autor:
Iris Yeong- Fung Sheng, C. Marcela Diaz-Montero, Patricia A. Rayman, Wei (Auston) Wei, Jaleh Fallah, James Finke, Jin Sub Kim, Paul G. Pavicic, Marcelo Lamenza, Donna Company, Andrew J. Stephenson, Steven Campbell, Georges-Pascal Haber, Byron H Lee, Omar Y. Mian, Timothy D. Gilligan, Brian I. Rini, Jorge A. Garcia, Petros Grivas, Moshe Chaim Ornstein
Publikováno v:
Journal of Clinical Oncology. 37:436-436
436 Background: MDSC have been linked to the chronic inflammatory microenvironment of tumor cells and pathologic outcomes in UC patients (pts) undergoing cystectomy. NLR is an established inflammatory biomarker with prognostic properties in mUC. We h
Autor:
Jaleh Fallah, C. Marcela Diaz-Montero, Patricia A. Rayman, Wei (Auston) Wei, Iris Yeong- Fung Sheng, James Finke, Jin Sub Kim, Paul G. Pavicic, Priscilla Dann, Donna Company, Andrew J. Stephenson, Steven Campbell, Georges-Pascal Haber, Byron H Lee, Omar Y. Mian, Timothy D. Gilligan, Brian I. Rini, Jorge A. Garcia, Petros Grivas, Moshe Chaim Ornstein
Publikováno v:
Journal of Clinical Oncology. 37:437-437
437 Background: MDSCs play an important role in maintaining a tumor immunosuppressive microenvironment. The association of circulating levels of MDSCs with pCR (pT0N0) and outcomes was investigated in patients (pts) with non-metastatic UC undergoing
Autor:
Haris Zahoor, Paul G Pavicic, Christopher Przybycin, Paul Elson, C. Marcela Diaz-Montero, James Finke, Patricia A. Rayman, Timothy D. Gilligan, Petros Grivas, Moshe Chaim Ornstein, Jorge A. Garcia, Brian I. Rini
Publikováno v:
Journal of Clinical Oncology. 35:4587-4587
4587 Background: TCI in tumors has been investigated as a biomarker of response to checkpoint inhibitors. A neo-adjuvant trial of checkpoint inhibition in locally-advanced RCC is ongoing at Cleveland Clinic, where TCI in pre-treatment renal mass bx w
Publikováno v:
Advances in experimental medicine and biology. 816
Renal cell carcinoma (RCC) constitutes more than 90 % of primary kidney tumors with the development of metastatic disease in the lung, bone, liver, and brain. Clear-cell RCC (CCRCC) is the most common histologic form of sporadic kidney cancer where t
Publikováno v:
The Journal of Immunology. 163:590-598
NF-κB is involved in the transcriptional control of various genes that act as extrinsic and intrinsic survival factors for T cells. Our findings show that suppression of NF-κB activity with cell-permeable SN50 peptide, which masks the nuclear local
Autor:
Weijun Ling, Patricia Rayman, Robert Uzzo, Peter Clark, Hyung Jin Kim, Raymond Tubbs, Andrew Novick, Ronald Bukowski, Thomas Hamilton, James Finke
Publikováno v:
Blood. 92:1334-1341
Activation of the transcription factor NFκB in peripheral blood T cells from patients with renal cell carcinoma (RCC) is compromised. This impaired signaling function results from a failure of RelA and c-Rel to translocate to the nucleus though norm
Autor:
Luis, Molto, Pat, Rayman, Ewa, Paszkiewicz-Kozik, Mark, Thornton, Lisa, Reese, John C, Thomas, Tanya, Das, Daisuke, Kudo, Ronald, Bukowski, James, Finke, Charles, Tannenbaum
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 9(11)
Tumors induce T-cell apoptosis as a mechanism of inhibiting antitumor immunity. Using coculture experiments, it has been shown that tumor lines stimulate T-cell apoptosis by a pathway involving a mitochondrial permeability transition and cytochrome c