Zobrazeno 1 - 10
of 10
pro vyhledávání: '"James, Chettle"'
Autor:
James Chettle, Raymond J. Louie, Olivia Larner, Robert Best, Kevin Chen, Josephine Morris, Zinaida Dedeic, Anna Childers, R. Curtis Rogers, Barbara R. DuPont, Cindy Skinner, Sébastien Küry, Kevin Uguen, Marc Planes, Danielle Monteil, Megan Li, Aviva Eliyahu, Lior Greenbaum, Nofar Mor, Thomas Besnard, Bertrand Isidor, Benjamin Cogné, Alyssa Blesson, Anne Comi, Ingrid M. Wentzensen, Blake Vuocolo, Seema R. Lalani, Roberta Sierra, Lori Berry, Kent Carter, Stephan J. Sanders, Sarah P. Blagden
Publikováno v:
HGG Advances, Vol 5, Iss 4, Pp 100345- (2024)
Summary: Autism spectrum disorder (ASD) is a neurodevelopmental disorder (NDD) that affects approximately 4% of males and 1% of females in the United States. While causes of ASD are multi-factorial, single rare genetic variants contribute to around 2
Externí odkaz:
https://doaj.org/article/e0e49cd5da4340678f3756e671807267
Autor:
Sebastian M.B. Nijman, Farasat Kazmi, In Hwa Um, Ruud G.P.M. van Stiphout, Gareth L. Bond, Mustafa Elshani, Valentina Ferrari, Ruth Plummer, David J. Harrison, Sarah P. Blagden, James Chettle, Mary Kudsy, Michaela Serpi, Stefan Symeonides, Josephine Morris, Hagen Schwenzer, Leticia Campo, Alistair Easton, Erica De Zan
Publikováno v:
Clinical Cancer Research. 27:6500-6513
Purpose: Nucleoside analogues form the backbone of many therapeutic regimens in oncology and require the presence of intracellular enzymes for their activation. A ProTide is comprised of a nucleoside fused to a protective phosphoramidate cap. ProTide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ad843422727b7b653fa57850e1f0ab05
https://doi.org/10.1158/1078-0432.ccr-21-1652
https://doi.org/10.1158/1078-0432.ccr-21-1652
Autor:
James Chettle, Zinaida Dedeic, Roman Fischer, Iolanda Vendrell, Leticia Campo, Alistair Easton, Molly Browne, Josephine Morris, Hagen Schwenzer, Pauline Lascaux, Rik Gijsbers, Elisabete Pires, Daniel J. Royston, David J. P. Ferguson, An Coosemans, Benedikt Kessler, James McCullagh, Ahmed A. Ahmed, Kristijan Ramadan, Martin Bushell, Adrian L. Harris, Colin R. Goding, Sarah P. Blagden
The protein mammalian target of rapamycin (mTOR) is a master regulator of cell homeostasis. Although mTOR is aberrantly overactivated in 70% ovarian cancers, mTOR cascade inhibitors (such as those blocking the kinase activity of mTOR itself or upstre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4d8462c75f390518b2b821ba0393ad55
https://doi.org/10.1101/2022.09.04.506559
https://doi.org/10.1101/2022.09.04.506559
Autor:
Sarah Bonham, Josephine Morris, Martin Fellermeyer, Roman Fischer, Andrew D Beggs, Joanne D. Stockton, James Chettle, Pia Neubert, Hagen Schwenzer, Sarah P. Blagden, Mai Abdel Mouti
Publikováno v:
RNA Biology
article-version (VoR) Version of Record
article-version (VoR) Version of Record
LARP1 is an oncogenic RNA-binding protein required for ribosome biogenesis and cancer cell survival. From published in vitro studies, there is disparity over which of two different LARP1 protein isoforms (termed the long LI-LARP1 and short SI-LARP1)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af9d83e75f29b92bbecceecdb8d29e7b
http://europepmc.org/articles/PMC7928056
http://europepmc.org/articles/PMC7928056
Autor:
Andrea J. Berman, Zinaida Dedeic, Sarah P. Blagden, James Chettle, Carson C. Thoreen, Philippe P. Roux
Publikováno v:
RNA Biology
article-version (VoR) Version of Record
article-version (VoR) Version of Record
The RNA-binding protein LARP1 has generated interest in recent years for its role in the mTOR signalling cascade and its regulation of terminal oligopyrimidine (TOP) mRNA translation. Paradoxically, some scientists have shown that LARP1 represses TOP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da1f7c47ca138788290af30583366b5b
http://europepmc.org/articles/PMC7928164
http://europepmc.org/articles/PMC7928164
Autor:
Hagen, Schwenzer, Erica, De Zan, Mustafa, Elshani, Ruud, van Stiphout, Mary, Kudsy, Josephine, Morris, Valentina, Ferrari, In Hwa, Um, James, Chettle, Farasat, Kazmi, Leticia, Campo, Alistair, Easton, Sebastian, Nijman, Michaela, Serpi, Stefan, Symeonides, Ruth, Plummer, David J, Harrison, Gareth, Bond, Sarah P, Blagden
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 27(23)
Nucleoside analogues form the backbone of many therapeutic regimens in oncology and require the presence of intracellular enzymes for their activation. A ProTide is comprised of a nucleoside fused to a protective phosphoramidate cap. ProTides are eas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1435cbfe29b519bf3ecbc035e215b2d0
https://pubmed.ncbi.nlm.nih.gov/34853073
https://pubmed.ncbi.nlm.nih.gov/34853073
Autor:
Erica de Zan, Mustafa Elshani, Michaela Serpi, Valentina Ferrari, Sarah P. Blagden, Sebastian M.B. Nijman, David J. Harrison, Hagen Schwenzer, Mary Kudsy, James Chettle, Josephine Morris, Ruud van Stiphout, Gareth P Bond
Publikováno v:
Cancer Research. 81:931-931
Background: 3'-deoxyadenosine (3'-dA; also known as cordycepin) is a nucleoside analog that has shown potent anti-cancer activity in non-clinical studies but has not been clinically developed because of its vulnerability to rapid degradation by the c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dff78a50087d1d665d5c0e1344f1ff74
https://doi.org/10.1158/1538-7445.am2021-931
https://doi.org/10.1158/1538-7445.am2021-931
Autor:
B.A. Blacklaws, Delphine Goubau, Caetano Reis e Sousa, Lucie Abeler-Dörner, Mahima Swamy, Probir Chakravarty, Adrian Hayday, Tanel Mahlakõiv, Jonathan L. Heeney, George Ramsay, Peter Staeheli, James Chettle
Publikováno v:
Nature Communications
Unrelenting environmental challenges to the gut epithelium place particular demands on the local immune system. In this context, intestinal intraepithelial lymphocytes (IEL) compose a large, highly conserved T cell compartment, hypothesized to provid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e3bb16957da2f8fddd048ec93187617
http://europepmc.org/articles/PMC4479038
http://europepmc.org/articles/PMC4479038
Autor:
Manuela Mura, John Le Quesne, Dahai Jiang, Cristian Rodriguez-Aguayo, Sarah P. Blagden, James Chettle, Gabriel Lopez-Berestein, Anil K. Sood, Essam Ghazaly, Chathunissa Gnanaranjan, Selanere Mangala, Chara Stavraka
Publikováno v:
Cancer Research. 77:B30-B30
Ovarian cancer is the most lethal of gynecological cancers killing 60% of women diagnosed with the disease within 5 years. The major contributor to this high mortality is the emergence of chemotherapy resistance; the tumor is initially sensitive to c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::82b69f0fc954382103f0253beb5fe93c
https://doi.org/10.1158/1538-7445.transcontrol16-b30
https://doi.org/10.1158/1538-7445.transcontrol16-b30
Autor:
Yuliya Demydchuk, James Chettle, Manuela Tosin, Hiroyuki Osada, Peter F. Leadlay, Frank Hahn, Yuhui Sun
Publikováno v:
Nature chemical biology
The protein phosphatase inhibitor RK-682 is one of a number of potentially valuable tetronate polyketide natural products. Understanding how the tetronate ring is formed has been frustrated by the inaccessibility of the putative substrates. We report
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bb79505900aabf22595974338f432b8
https://doi.org/10.1038/nchembio.285
https://doi.org/10.1038/nchembio.285