Výsledky vyhledávání - "James, Cardelli"

Akademický článek

Modulating lysosomal function through lysosome membrane permeabilization or autophagy suppression restores sensitivity to cisplatin in refractory non-small-cell lung cancer cells.

Autor: Magdalena Circu, James Cardelli, Martin P Barr, Kenneth O'Byrne, Glenn Mills, Hazem El-Osta

Publikováno v: PLoS ONE, Vol 12, Iss 9, p e0184922 (2017)

Lung cancer is the leading cause of cancer-related deaths. Most patients develop resistance to platinum within several months of treatment. We investigated whether triggering lysosomal membrane permeabilization (LMP) or suppressing autophagy can rest

Externí odkaz: https://doaj.org/article/4991f40102d04804a67760c369a679f2

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Akademický článek

Identification of small molecules that disrupt vacuolar function in the pathogen Candida albicans.

Autor: Helene Tournu, Jennifer Carroll, Brian Latimer, Ana-Maria Dragoi, Samantha Dykes, James Cardelli, Tracy L Peters, Karen E Eberle, Glen E Palmer

Publikováno v: PLoS ONE, Vol 12, Iss 2, p e0171145 (2017)

The fungal vacuole is a large acidified organelle that performs a variety of cellular functions. At least a sub-set of these functions are crucial for pathogenic species of fungi, such as Candida albicans, to survive within and invade mammalian tissu

Externí odkaz: https://doaj.org/article/fa1b4889e65b408495d5ffedc4f469eb

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Akademický článek

A Novel High Content Imaging-Based Screen Identifies the Anti-Helminthic Niclosamide as an Inhibitor of Lysosome Anterograde Trafficking and Prostate Cancer Cell Invasion.

Autor: Magdalena L Circu, Samantha S Dykes, Jennifer Carroll, Kinsey Kelly, Floyd Galiano, Adam Greer, James Cardelli, Hazem El-Osta

Publikováno v: PLoS ONE, Vol 11, Iss 1, p e0146931 (2016)

Lysosome trafficking plays a significant role in tumor invasion, a key event for the development of metastasis. Previous studies from our laboratory have demonstrated that the anterograde (outward) movement of lysosomes to the cell surface in respons

Externí odkaz: https://doaj.org/article/2f097157e0174c958c65d78ad97492fe

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Akademický článek

Correction: A Novel High Content Imaging-Based Screen Identifies the Anti-Helminthic Niclosamide as an Inhibitor of Lysosome Anterograde Trafficking and Prostate Cancer Cell Invasion.

Autor: Magdalena L Circu, Samantha S Dykes, Jennifer Carroll, Kinsey Kelly, Floyd Galiano, Adam Greer, James Cardelli, Hazem El-Osta

Publikováno v: PLoS ONE, Vol 11, Iss 3, p e0151718 (2016)

Externí odkaz: https://doaj.org/article/ba9079fa8dbf402d83b8c0a385e9bf4d

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Modulating lysosomal function through lysosome membrane permeabilization or autophagy suppression restores sensitivity to cisplatin in refractory non-small-cell lung cancer cells

Autor: Magdalena Circu, James Cardelli, Martin P Barr, Kenneth O'Byrne, Glenn Mills, Hazem El-Osta

Publikováno v: PLoS ONE
PLoS ONE, Vol 13, Iss 5, p e0197016 (2018)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57fdea1827063534dfb6ec09019f852d
https://doi.org/10.1371/journal.pone.0197016

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Knockdown of core binding factorβ alters sphingolipid metabolism

Autor: Adam H, Greer, Thomas, Yong, Katie, Fennell, Yara W, Moustafa, Marcie, Fowler, Floyd, Galiano, Shu-Wing, Ng, Ross S, Berkowitz, James, Cardelli, Shari, Meyers, J Nathan, Davis

Publikováno v: Journal of cellular physiology. 228(12)

Core binding factor (CBF) is a heterodimeric transcription factor containing one of three DNA-binding proteins of the Runt-related transcription factor family (RUNX1-3) and the non-DNA-binding protein, CBFβ. RUNX1 and CBFβ are the most common targe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::5fe728e6b0d33cde1dd04155fa6aeb41
https://pubmed.ncbi.nlm.nih.gov/23813439

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Large-scale purification of latex bead phagosomes from mouse macrophage cell lines and subsequent preparation for high-throughput quantitative proteomics

Autor: Adam, Rupper, James, Cardelli

Publikováno v: Methods in molecular biology (Clifton, N.J.). 445

Phagocytosis involves the engagement of a diverse array of cell surface receptors whose signal must be integrated on the membrane of the forming phagosomal cup. This method enables the quantitative proteomic analysis of phagosome fractions derived fr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9c0de41cc27c26e67a4e2228eb2d1684
https://pubmed.ncbi.nlm.nih.gov/18425461

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The regulation of phagosome maturation in Dictyostelium

Autor: Damian, Duhon, James, Cardelli

Publikováno v: Journal of muscle research and cell motility. 23(7-8)

Macropinocytosis (fluid uptake) and phagocytosis (particle uptake) are processes that result in the formation of intracellular membrane enclosed vacuoles termed macropinosomes and phagosomes, respectively. Macropinosomes and phagosomes are modified b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::87d4c0dd8cf4be14cd4806e482c3b222
https://pubmed.ncbi.nlm.nih.gov/12952078

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