Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Jamal Elkhader"'
Autor:
Coryandar Gilvary, Jamal Elkhader, Neel Madhukar, Claire Henchcliffe, Marcus D Goncalves, Olivier Elemento
Publikováno v:
PLoS Computational Biology, Vol 16, Iss 8, p e1008098 (2020)
Drug repurposing, identifying novel indications for drugs, bypasses common drug development pitfalls to ultimately deliver therapies to patients faster. However, most repurposing discoveries have been led by anecdotal observations (e.g. Viagra) or ex
Externí odkaz:
https://doaj.org/article/b1f616d0a35042f5b2341dd32c460420
Supplementary Figure S4 PDF file 42K, Therapeutic efficacy of Lip-�CD137 or Lip-IL-2Fc as monotherapy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5553df6ec884cb72908a2bf051ab4216
https://doi.org/10.1158/0008-5472.22396922.v1
https://doi.org/10.1158/0008-5472.22396922.v1
Supplementary Figure Legends PDF file 84K, Legends for supplementary figures S1-S7
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b8cb48d38db68ae98f2d0f6a220234d
https://doi.org/10.1158/0008-5472.22396934.v1
https://doi.org/10.1158/0008-5472.22396934.v1
Autor:
Claire Henchcliffe, Coryandar Gilvary, Jamal Elkhader, Neel Madhukar, Olivier Elemento, Marcus D. Goncalves
Publikováno v:
PLoS Computational Biology, Vol 16, Iss 8, p e1008098 (2020)
PLoS computational biology, vol 16, iss 8
PLoS Computational Biology
PLoS computational biology, vol 16, iss 8
PLoS Computational Biology
Drug repurposing, identifying novel indications for drugs, bypasses common drug development pitfalls to ultimately deliver therapies to patients faster. However, most repurposing discoveries have been led by anecdotal observations (e.g. Viagra) or ex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1981b586062ac220e590c8b8ce5b7802
https://doaj.org/article/b1f616d0a35042f5b2341dd32c460420
https://doaj.org/article/b1f616d0a35042f5b2341dd32c460420
Publikováno v:
Trends in pharmacological sciences. 40(8)
Stakeholders across the entire healthcare chain are looking to incorporate artificial intelligence (AI) into their decision-making process. From early-stage drug discovery to clinical decision support systems, we have seen examples of how AI can impr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::075119439d46b6707c563375acdc1b4a
https://pubmed.ncbi.nlm.nih.gov/31277839
https://pubmed.ncbi.nlm.nih.gov/31277839
Publikováno v:
Cancer Research. 79:682-682
Despite recent advances in life sciences and technology, bringing a single drug to market has stayed drastically expensive, leading to a decline in the number of new drugs being clinically approved. Drug repurposing, identifying novel indications for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cb115cd56830dec7a18544c68c24ebc8
https://doi.org/10.1158/1538-7445.am2019-682
https://doi.org/10.1158/1538-7445.am2019-682
Publikováno v:
PMC
Immunostimulatory agonists such as anti-CD137 and interleukin (IL)-2 have elicited potent antitumor immune responses in preclinical studies, but their clinical use is limited by inflammatory toxicities that result upon systemic administration. We hyp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68bb098f5d46883571595d06c831908e
https://doi.org/10.1158/0008-5472.can-12-3343
https://doi.org/10.1158/0008-5472.can-12-3343
Autor:
Wuhbet Abraham, Dan H. Barouch, Peter C. DeMuth, Hualin Li, Adrienne V. Li, Kelly Stanley, Paula T. Hammond, Kaitlin M. Smith, Heikyung Suh, Christy L. Lavine, Michael S. Seaman, Jinyan Liu, Darrell J. Irvine, Joshua A. Kramer, Andrew D. Miller, Jamal Elkhader, Peter Abbink
Publikováno v:
PMC
Nature biotechnology
Nature biotechnology
Transcutaneous drug delivery from planar skin patches is effective for small-molecule drugs and skin-permeable vaccine adjuvants. However, to achieve efficient delivery of vaccines and other macromolecular therapeutics into the skin, penetration of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::419c78a32f411ccaef542b72d633e15a
https://orcid.org/0000-0003-0787-298X
https://orcid.org/0000-0003-0787-298X
Autor:
James J. Moon, Dan H. Barouch, Jamal Elkhader, Michael A. Seidman, Darrell J. Irvine, Wuhbet Abraham, Maria Hottelet Foley, Minmin Yen, Adrienne V. Li, Eung Jun Im, Heikyung Suh
Publikováno v:
PMC
Many pathogens infiltrate the body and initiate infection via mucosal surfaces. Hence, eliciting cellular immune responses at mucosal portals of entry is of great interest for vaccine development against mucosal pathogens. We describe a pulmonary vac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c980c7f012c57fefb79f740ea88fab8c
https://doi.org/10.1126/scitranslmed.3006516
https://doi.org/10.1126/scitranslmed.3006516
Autor:
Adrienne Li, James Moon, Jamal Elkhader, Mimi Yen, Wuhbet Abraham, Heikyung Suh, Darrell Irvine
Publikováno v:
The Journal of Immunology. 188:113.21-113.21
Mucosal vaccines offer needle-free administration and can stimulate immune responses systemically and at mucosal sites. “Vectorless” vaccines based on antigens packaged in synthetic nanoparticles (NPs) offer potential advantages in manufacturing,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::87e9ba83ecafea7b4b5f99095df72847
https://doi.org/10.4049/jimmunol.188.supp.113.21
https://doi.org/10.4049/jimmunol.188.supp.113.21