Zobrazeno 1 - 10
of 102
pro vyhledávání: '"Jamal Bouitbir"'
Autor:
Lea S Blaser, Urs Duthaler, Jamal Bouitbir, Anne B Leuppi-Taegtmeyer, Evangelia Liakoni, Reto Dolf, Michael Mayr, Jürgen Drewe, Stephan Krähenbühl, Manuel Haschke
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Aim: The objective was to investigate the effect of metamizole on renal function in healthy, salt-depleted volunteers. In addition, the pharmacokinetics of the four major metamizole metabolites were assessed and correlated with the pharmacodynamic ef
Externí odkaz:
https://doaj.org/article/90f5c5c6045e47539c09d00108323638
Autor:
Jamal Bouitbir, Miljenko Valentin Panajatovic, Theo Frechard, Noëmi Johanna Roos, Stephan Krähenbühl
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2020)
Tyrosine kinase inhibitors (TKIs) can cause skeletal muscle toxicity in patients, but the underlying mechanisms are mostly unclear. The goal of the current study was to better characterize the role of mitochondria in TKI-associated myotoxicity. We ex
Externí odkaz:
https://doaj.org/article/d08aa1bd952e46a3a84c2130decfb8e6
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2020)
The receptor tyrosine kinase inhibitor lapatinib, indicated to treat patients with HER2-positive breast cancer in combination with capecitabine, can cause severe hepatotoxicity. Lapatinib is further associated with mitochondrial toxicity and accumula
Externí odkaz:
https://doaj.org/article/304488ceebe54538b7c33266ec95e3f0
Publikováno v:
Frontiers in Pharmacology, Vol 10 (2019)
We will present a 42-year-old woman with acute myeloid leukemia and pulmonary aspergillosis. She was treated with several antifungal agents, including three triazoles. Voriconazole, posaconazole, and isavuconazole all led to hepatocellular liver inju
Externí odkaz:
https://doaj.org/article/dd5e199217194961b82c02847bbabd1e
Publikováno v:
Biomedicines, Vol 8, Iss 9, p 351 (2020)
Several studies showed an increased risk for diabetes with statin treatment. PGC-1α is an important regulator of muscle energy metabolism and mitochondrial biogenesis. Since statins impair skeletal muscle PGC-1α expression and reduced PGC-1α expre
Externí odkaz:
https://doaj.org/article/2b0ec6dc8af04968a7bde70f343420f6
Publikováno v:
Metabolites, Vol 10, Iss 7, p 282 (2020)
Bile acids control lipid homeostasis by regulating uptake from food and excretion. Additionally, bile acids are bioactive molecules acting through receptors and modulating various physiological processes. Impaired bile acid homeostasis is associated
Externí odkaz:
https://doaj.org/article/746a74b3ce954ef398b21588cec442b4
Publikováno v:
Biomedicines, Vol 8, Iss 7, p 212 (2020)
Metamizole is an analgesic, whose pharmacological and toxicological properties are attributed to N-methyl-aminoantipyrine (MAA), its major metabolite. In the presence of heme iron, MAA forms reactive metabolites, which are toxic for granulocyte precu
Externí odkaz:
https://doaj.org/article/89e52af7b8b14f85a83b4c817599a20b
Publikováno v:
Cells, Vol 9, Iss 4, p 965 (2020)
Hyperthermia is one of the severe acute adverse effects that can be caused by the ingestion of recreational drugs, such as methcathinones. The effect of hyperthermia on neurotoxicity is currently not known. The primary aim of our study was therefore
Externí odkaz:
https://doaj.org/article/9215721c3f38462fae207a6302d0c4aa
Autor:
Julien Pottecher, Chris Adamopoulos, Anne Lejay, Jamal Bouitbir, Anne-Laure Charles, Alain Meyer, Mervyn Singer, Valerie Wolff, Pierre Diemunsch, Gilles Laverny, Daniel Metzger, Bernard Geny
Publikováno v:
Frontiers in Physiology, Vol 9 (2018)
Objectives: Diabetic patients respond poorly to revascularization for peripheral arterial disease (PAD) but the underlying mechanisms are not well understood. We aimed to determine whether diabetes worsens ischemia-reperfusion (IR)-induced muscle dys
Externí odkaz:
https://doaj.org/article/ebdc17a3824c4b93a7cf99d9b348fe6e
Publikováno v:
Frontiers in Pharmacology, Vol 8 (2017)
Tyrosine kinase inhibitors (TKIs) are anticancer drugs with a lesser toxicity than classical chemotherapeutic agents but still with a narrow therapeutic window. While hepatotoxicity is known for most TKIs, underlying mechanisms remain mostly unclear.
Externí odkaz:
https://doaj.org/article/0b10a7289b494c778ece0d1ba486b805