Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Jamal B. Williams"'
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-9 (2024)
Abstract The primary purpose of this study is to highlight trends in the prevalence of attention deficit/hyperactivity disorders (ADHD) and conduct disorders (CD) between non-Hispanic White and non-Hispanic Black populations and identify potential di
Externí odkaz:
https://doaj.org/article/7f93677bafc34185a762b2b5ee495682
Autor:
Jamal B. Williams, Qing Cao, Wei Wang, Young-Ho Lee, Luye Qin, Ping Zhong, Yong Ren, Kaijie Ma, Zhen Yan
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
The study by Williams et al shows targeting the aberrant histone modifying enzyme Smyd3 rescues NMDAR and cognitive deficits in a mouse model of Alzheimer’s disease. It highlights the potential of epigenetic treatment in neurodegenerative diseases.
Externí odkaz:
https://doaj.org/article/0e0ce2cb83474727ba28a20c2c341e56
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
ASH1L haploinsufficiency is strongly linked to autism, despite the unknown mechanism. Here, the authors show that ASH1L deficiency in prefrontal cortex causes the downregulation of synaptic genes, leading to seizures, which is rescued by chemogenetic
Externí odkaz:
https://doaj.org/article/9cf490f4547141f4a572a7d190a6884a
Autor:
Maximiliano Rapanelli, Jamal B. Williams, Kaijie Ma, Fengwei Yang, Ping Zhong, Rajvi Patel, Manasa Kumar, Luye Qin, Benjamin Rein, Zi-Jun Wang, Bibi Kassim, Behnam Javidfar, Lizette Couto, Schahram Akbarian, Zhen Yan
Publikováno v:
Molecular Psychiatry. 27:3355-3366
Large-scale genetic studies have revealed that the most prominent genes disrupted in autism are chromatin regulators mediating histone methylation/demethylation, suggesting the central role of epigenetic dysfunction in this disorder. Here, we show th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6aa2e73f74973eedb56181f42fb0d5fa
https://doi.org/10.1038/s41380-022-01508-8
https://doi.org/10.1038/s41380-022-01508-8
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Nature Communications
Nature Communications
ASH1L, a histone methyltransferase, is identified as a top-ranking risk factor for autism spectrum disorder (ASD), however, little is known about the biological mechanisms underlying the link of ASH1L haploinsufficiency to ASD. Here we show that ASH1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3abb59d155278d31fcd2065824f00f5c
https://doaj.org/article/9cf490f4547141f4a572a7d190a6884a
https://doaj.org/article/9cf490f4547141f4a572a7d190a6884a
Autor:
Ben Rein, Ping Zhong, Freddy Zhang, Kaijie Ma, Fengwei Yang, Zi-Jun Wang, Qing Cao, Jamal B Williams, Zhen Yan
Publikováno v:
Neuropsychopharmacology
Large-scale genetic screening has identified KMT5B (SUV420H1), which encodes a histone H4 K20 di- and tri-methyltransferase highly expressed in prefrontal cortex (PFC), as a top-ranking high-risk gene for autism. However, the biological function of K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fedb9e2f35655bd2d9c6c318be1e0683
https://doi.org/10.1038/s41386-021-01029-y
https://doi.org/10.1038/s41386-021-01029-y
Autor:
Megan Conrow-Graham, Jamal B Williams, Jennifer Martin, Ping Zhong, Qing Cao, Benjamin Rein, Zhen Yan
Publikováno v:
Brain
ADNP and POGZ are two top-ranking risk factors for autism spectrum disorder and intellectual disability, but how they are linked to these neurodevelopmental disorders is largely unknown. Both ADNP and POGZ are chromatin regulators, which could profou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eaf0868fb5946b2c8d5f09a67ab325d7
https://pubmed.ncbi.nlm.nih.gov/35775424
https://pubmed.ncbi.nlm.nih.gov/35775424
Autor:
Jamal B. Williams, Qing Cao, Wei Wang, Young-Ho Lee, Luye Qin, Ping Zhong, Yong Ren, Kaijie Ma, Zhen Yan
Publikováno v:
Nature communications. 14(1)
Pleiotropic mechanisms have been implicated in Alzheimer’s disease (AD), including transcriptional dysregulation, protein misprocessing and synaptic dysfunction, but how they are mechanistically linked to induce cognitive deficits in AD is unclear.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a4f8101c069d36a548e09394e27293b
https://pubmed.ncbi.nlm.nih.gov/36609445
https://pubmed.ncbi.nlm.nih.gov/36609445
Publikováno v:
Aging Cell
Epigenetic abnormality is implicated in neurodegenerative diseases associated with cognitive deficits, such as Alzheimer's disease (AD). A common feature of AD is the accumulation of neurofibrillary tangles composed of hyperphosphorylated tau. Transg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94e2b2a3b7b227d235a8705162c019c5
https://pubmed.ncbi.nlm.nih.gov/34547169
https://pubmed.ncbi.nlm.nih.gov/34547169
Publikováno v:
Brain Communications
Alzheimer’s disease is a progressive neurodegenerative disorder associated with memory loss and impaired executive function. The molecular underpinnings causing cognitive deficits in Alzheimer’s disease are loosely understood. Here, we performed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1c00dd8560e381f352131c7183a8234
https://doi.org/10.1093/braincomms/fcab123
https://doi.org/10.1093/braincomms/fcab123