Modeling the human Nav1.5 sodium channel: structural and mechanistic insights of ion permeation and drug blockade

Autor: Ahmed M, Jalily Hasani H, Ganesan A, Houghton M, Barakat K

Publikováno v: Drug Design, Development and Therapy, Vol Volume 11, Pp 2301-2324 (2017)

Marawan Ahmed,1 Horia Jalily Hasani,1,* Aravindhan Ganesan,1,* Michael Houghton,2–4 Khaled Barakat1–3 1Faculty of Pharmacy and Pharmaceutical Sciences, 2Li Ka Shing Institute of Virology, 3Li Ka Shing Applied Virology Institute, 4Department of Me

Externí odkaz: https://doaj.org/article/aa00505d5f2443d2b1eba468bcd77dc7

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Effects of protein-protein interactions and ligand binding on the ion permeation in KCNQ1 potassium channel.

Autor: Jalily Hasani H; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta, Canada., Ganesan A; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta, Canada., Ahmed M; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta, Canada., Barakat KH; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta, Canada.; Li Ka Shing Institute of Virology, University of Alberta, Edmonton, Alberta, Canada.; Li Ka Shing Applied Virology Institute, University of Alberta, Edmonton, Alberta, Canada.

Publikováno v: PloS one [PLoS One] 2018 Feb 14; Vol. 13 (2), pp. e0191905. Date of Electronic Publication: 2018 Feb 14 (Print Publication: 2018).