Encoding and Transducing the Synaptic or Extrasynaptic Origin of NMDA Receptor Signals to the Nucleus

Autor: Werner Zuschratter, Marina Mikhaylova, Eckart D. Gundelfinger, Jale Sahin, Philipp Bethge, Michael R. Kreutz, Thilo Kähne, Rahul Kaushik, Sujoy Bera, Christina Spilker, Thomas Behnisch, Vladan Rankovic, Michael Naumann, Anna Karpova, Julia Bär, Pasham Parameshwar Reddy

Publikováno v: Cell. 152(5):1119-1133

SummaryThe activation of N-methyl-D-aspartate-receptors (NMDARs) in synapses provides plasticity and cell survival signals, whereas NMDARs residing in the neuronal membrane outside synapses trigger neurodegeneration. At present, it is unclear how the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cba422118470e177fd39cabeaa7b1cae

A comparison of the synaptic proteome in human chronic schizophrenia and rat ketamine psychosis suggest that prohibitin is involved in the synaptic pathology of schizophrenia

Autor: Ka Wan Li, Andrea Schmitt, Jale Sahin, Michael R. Kreutz, Karl-Heinz Smalla, Eckart D. Gundelfinger, Marina Mikhaylova, H.-G. Bernstein, B. Bogerts, August B. Smit, R.C. van der Schors

Publikováno v: Smalla, K H, Mikhaylova, M, Sahin, J, Bernstein, H G, Bogerts, B, Schmitt, A, van der Schors, R C, Smit, A B, Li, K W, Gundelfinger, E D & Kreutz, M R 2008, ' A comparison of the synaptic proteome in human chronic schizophrenia and rat ketamine psychosis suggest that prohibitin is involved in the synaptic pathology of schizophrenia ', Molecular Psychiatry, vol. 13, pp. 878-896 . https://doi.org/10.1038/mp.2008.60
Molecular Psychiatry, 13, 878-896. Nature Publishing Group

Many studies in recent years suggest that schizophrenia is a synaptic disease that crucially involves a hypofunction of N-methyl-D-aspartate receptor-mediated signaling. However, at present it is unclear how these pathological processes are reflected

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39c15e67e8917181763ba1854a93bd58
https://hdl.handle.net/1871.1/931a3e54-0c70-4844-ae68-be7eaaee348b

A reduced number of cortical neurons show increased Caldendrin protein levels in chronic schizophrenia

Autor: Eckart D. Gundelfinger, Michael R. Kreutz, Bernhard Bogerts, Karl-Heinz Smalla, Hans-Gert Bernstein, Jale Sahin

Publikováno v: Schizophrenia research. 96(1-3)

Caldendrin is a neuronal calcium sensor protein that is tightly associated with the postsynaptic density (PSD) of excitatory synapses. It has an established role in synapto-dendritic Ca 2+ -signaling as a multifunctional regulator of intracellular Ca

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05022c4213d1e48cadeb56027ddb3a7e
https://pubmed.ncbi.nlm.nih.gov/17719205