Výsledky vyhledávání - "Jalal Vakili"

Results of the Belgian expanded access program of eribulin in the treatment of metastatic breast cancer closely mirror those of the pivotal phase III trial

Autor: Jalal Vakili, Christiane Jungels, Andrea Gombos, Ahmad Awada, Lieveke Ameye, Martine Piccart-Gebhart, Marianne Paesmans, Philippe Aftimos, Laura Polastro, Dominique de Valeriola, Alfino Buttice, Thierry Gil, Joanne van den Eerenbeemt

Publikováno v: European journal of cancer (Oxford, England : 1990). 60

Background Eribulin is a non-taxane microtubule dynamics inhibitor that showed a survival benefit versus treatment of physician's choice in a phase III trial enrolling patients with metastatic breast cancer (MBC). Methods The E7389-G000-398 trial was

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a5d7fc5099c5a187720e41d14daded3
https://pubmed.ncbi.nlm.nih.gov/27107326

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Quantum Proteolytic Activation of Chemokine CCL15 by Neutrophil Granulocytes Modulates Mononuclear Cell Adhesiveness

Autor: S.E. Escher, Wolf-Georg Forssmann, Ulf Forssmann, Reinhard Henschler, Roxana Bistrian, Adjoa Frimpong-Boateng, Jalal Vakili, Nikolaj Spodsberg, Rudolf Richter

Publikováno v: The Journal of Immunology. 175:1599-1608

Monocyte infiltration into inflammatory sites is generally preceded by neutrophils. We show here that neutrophils may support this process by activation of CCL15, a human chemokine circulating in blood plasma. Neutrophils were found to release CCL15

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6caf5c752e81a7b176d57c24050ebf2c
https://doi.org/10.4049/jimmunol.175.3.1599

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Functional characterization of a human receptor for neuropeptide FF and related peptides

Autor: Jalal Vakili, Catherine Mollereau, Michel Detheux, Marc Parmentier, Masato Kotani, Stéphane Brézillon, Honoré Mazarguil, Gilbert Vassart, Jean-Marie Zajac, Emmanuel Le Poul

Publikováno v: British Journal of Pharmacology. 133:138-144

1. Neuropeptides FF (NPFF) and AF (NPAF) are involved in pain modulation and opioid tolerance. These peptides were known to act through uncharacterized G protein-coupled receptors (GPCR). We describe here, using an aequorin-based assay as screening t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5d7cd6f027d2edadd9f800d957244be0
https://doi.org/10.1038/sj.bjp.0704038

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Natural Proteolytic Processing of Hemofiltrate Cc Chemokine 1 Generates a Potent Cc Chemokine Receptor (Ccr)1 and Ccr5 Agonist with Anti-HIV Properties

Autor: Marc Parmentier, Jan Münch, Gilbert Vassart, Frank Kirchhoff, Ulf Forssmann, Ludger Ständker, Stefan Pöhlmann, Jalal Vakili, Knut Adermann, Michel Detheux, Wolf-Georg Forssmann

Publikováno v: The Journal of Experimental Medicine

Hemofiltrate CC chemokine (HCC)-1 is a recently described human chemokine that is constitutively expressed in numerous tissues and is present at high concentrations in normal plasma. Using a cell line expressing CC chemokine receptor (CCR)5 as a bioa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96db76135fe5280b88a1ad154ac1fd96
https://doi.org/10.1084/jem.192.10.1501

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Multiple Charged and Aromatic Residues in CCR5 Amino-terminal Domain Are Involved in High Affinity Binding of Both Chemokines and HIV-1 Env Protein

Autor: Jalal Vakili, Olivier Lorthioir, Frédérick Libert, Françoise Baleux, Gilbert Vassart, Benjamin J. Doranz, Joseph Rucker, Marc Parmentier, Isabelle Migeotte, Sarah S.W. Baik, Cédric Govaerts, Robert W. Doms, Cédric Blanpain

Publikováno v: Journal of Biological Chemistry. 274:34719-34727

CCR5 is a functional receptor for MIP-1alpha, MIP-1beta, RANTES (regulated on activation normal T cell expressed), MCP-2, and MCP-4 and constitutes the main coreceptor for macrophage tropic human and simian immunodeficiency viruses. By using CCR5-CCR

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63686a8e7ed347002a12c6660c631946
https://doi.org/10.1074/jbc.274.49.34719

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CCR5 Binds Multiple CC-Chemokines: MCP-3 Acts as a Natural Antagonist

Autor: Robert W. Doms, Cédric Govaerts, Jalal Vakili, Marc Parmentier, Benhur Lee, Cédric Blanpain, Gilbert Vassart, Isabelle Migeotte, Benjamin J. Doranz

Publikováno v: Blood. 94:1899-1905

CCR5 was first characterized as a receptor for MIP-1alpha, MIP-1beta, and RANTES, and was rapidly shown to be the main coreceptor for M-tropic human immunodeficiency virus (HIV)-1 strains and simian immunodeficiency virus (SIV). Chemokines constitute

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::703d8f06d1c9045eadb194d54110f9ae
https://doi.org/10.1182/blood.v94.6.1899.418k31_1899_1905

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Extracellular Cysteines of CCR5 Are Required for Chemokine Binding, but Dispensable for HIV-1 Coreceptor Activity

Autor: Isabelle Migeotte, Jalal Vakili, Benhur Lee, Marc Parmentier, Cédric Blanpain, Cédric Govaerts, Matthew Sharron, Vincent Dupriez, Gilbert Vassart, Benjamin J. Doranz, Robert W. Doms

Publikováno v: Journal of Biological Chemistry. 274:18902-18908

CCR5 is the major coreceptor for macrophage-tropic human immunodeficiency virus type I (HIV-1). For most G-protein-coupled receptors that have been tested so far, the disulfide bonds linking together the extracellular loops (ECL) are required for mai

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21e98b04d3f641dc79e98eb8ca5f4485
https://doi.org/10.1074/jbc.274.27.18902

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Significance of N-terminal proteolysis of CCL14a to activity on the chemokine receptors CCR1 and CCR5 and the human cytomegalovirus-encoded chemokine receptor US28

Autor: Jalal Vakili, Jan Münch, Henry F. Vischer, Ludger Ständker, Paola Casarosa, Rob Leurs, Martine J. Smit, Rudolf Richter, Jean-Yves Springael, Saskia Nijmeijer, Wolf-Georg Forssmann, Marc Parmentier, Michel Detheux

Publikováno v: Richter, R, Casarosa, P, Standker, L, Munch, J, Springael, J Y, Nijmeijer, S, Forssmann, W G, Vischer, H F, Vakili, J, Detheux, M, Parmentier, M, Leurs, R & Smit, M J 2009, ' Significance of N-terminal proteolysis of CCL14a to activity on the chemokine receptors CCR1 and CCR5 and the human cytomegalovirus-encoded chemokine receptor US28 ', Journal of Immunology, vol. 183, no. 2, pp. 1229-37 . https://doi.org/10.4049/jimmunol.0802145
Journal of Immunology, 183(2), 1229-37. American Association of Immunologists

The CC chemokine CCL14a is constitutively expressed in a large variety of tissues and its inactive proform CCL14a(1–74) circulates in high concentrations in plasma. CCL14a(1–74) is converted into CCL14a(9–74) by the proteases urokinase-type pla

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::028c72f032fba36bd1d1f674d0d66002
https://research.vu.nl/en/publications/62f52cf8-b9a2-46c2-84f8-c3eb425220e5

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