Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Jalal M. Kazan"'
Autor:
Jalal M. Kazan, Guillaume Desrochers, Claire E. Martin, Hyeonju Jeong, Dmitri Kharitidi, Pirjo M. Apaja, Ariel Roldan, Nicole St. Denis, Anne-Claude Gingras, Gergely L. Lukacs, Arnim Pause
Publikováno v:
iScience, Vol 24, Iss 11, Pp 103274- (2021)
Summary: Internalized and ubiquitinated signaling receptors are silenced by their intraluminal budding into multivesicular bodies aided by the endosomal sorting complexes required for transport (ESCRT) machinery. HD-PTP, an ESCRT protein, forms compl
Externí odkaz:
https://doaj.org/article/f8eb2fe20c114718a6151e5c0fe42afc
Autor:
Layal EL-Hajjar, Abdullah Shaito, Nour Jalaleddine, Kazem Zibara, Jalal M. Kazan, Jamal El-Saghir, Marwan El-Sabban
Publikováno v:
Data in Brief, Vol 22, Iss , Pp 635-638 (2019)
Bevacizumab or Avastin® (Av), the recombinant antibody targeting VEGF, improves progression-free but not overall survival of metastatic breast cancer patients due to development of Av resistance. We showed that Av-therapy-induced inflammatory microe
Externí odkaz:
https://doaj.org/article/33e7114a9460458e83134242ea4591c2
Autor:
Leeanna El-Houjeiri, Elite Possik, Tarika Vijayaraghavan, Mathieu Paquette, José A. Martina, Jalal M. Kazan, Eric H. Ma, Russell Jones, Paola Blanchette, Rosa Puertollano, Arnim Pause
Publikováno v:
Cell Reports, Vol 26, Iss 13, Pp 3613-3628.e6 (2019)
Summary: TFEB and TFE3 are transcriptional regulators of the innate immune response, but the mechanisms regulating their activation upon pathogen infection are poorly elucidated. Using C. elegans and mammalian models, we report that the master metabo
Externí odkaz:
https://doaj.org/article/246d937dce1a41f48fa99b90e869b2e7
Autor:
Anne-Claude Gingras, Jalal M. Kazan, Hyeonju Jeong, Arnim Pause, Pirjo M. Apaja, Gergely L. Lukacs, Nicole St. Denis, Ariel Roldan, Claire E. Martin, Guillaume Desrochers, Dmitri Kharitidi
Publikováno v:
iScience
iScience, Vol 24, Iss 11, Pp 103274-(2021)
iScience, Vol 24, Iss 11, Pp 103274-(2021)
Summary Internalized and ubiquitinated signaling receptors are silenced by their intraluminal budding into multivesicular bodies aided by the endosomal sorting complexes required for transport (ESCRT) machinery. HD-PTP, an ESCRT protein, forms comple
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6347425a68df1bf344d548d1f9888474
http://europepmc.org/articles/PMC8567383
http://europepmc.org/articles/PMC8567383
Publikováno v:
STAR Protocols. 3:101475
EGFR cell surface density, stability, internalization, and recycling can be measured by cell surface ELISA (cs-ELISA). Performing this experiment on ice impedes receptor internalization; thus the physiological cell surface receptor levels can be meas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ce961628f94bbc49a04dc275a1b0734
https://doi.org/10.1016/j.xpro.2022.101475
https://doi.org/10.1016/j.xpro.2022.101475
Publikováno v:
Biochemistry and Cell Biology. 97:68-72
Cell surface receptors trigger the activation of signaling pathways to regulate key cellular processes, including cell survival and proliferation. Internalization, sorting, and trafficking of activated receptors, therefore, play a major role in the r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a31eb1afd91779cefe7c92f44eea9bcd
https://doi.org/10.1139/bcb-2017-0322
https://doi.org/10.1139/bcb-2017-0322
Autor:
Layal El-Hajjar, Kazem Zibara, Jamal El-Saghir, Jalal M. Kazan, Marwan El-Sabban, Abdullah Shaito, Nour Jalaleddine
Publikováno v:
Cellular Signalling. 53:400-412
Background Bevacizumab or Avastin® (Av) is an anti-vascular endothelial growth factor agent. It does not improve survival of breast cancer patients due to development of refractoriness. Av treatment was shown to increase inflammation in a diabetic m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bcaf2763c2f6f2ea9332637f02cdf32
https://doi.org/10.1016/j.cellsig.2018.11.007
https://doi.org/10.1016/j.cellsig.2018.11.007
Publikováno v:
Clinical Immunology. 181:9-15
We aimed to investigate the immunologic effects of vitamin D replacement in RRMS patients. In a controlled single center study, patients deficient in 25-hydroxyvitamin D (serum level 35 ng/ml) were followed for the same period. Assessments were perfo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae0d65fac6f3f4f0fd22089a7a596b41
https://doi.org/10.1016/j.clim.2017.05.017
https://doi.org/10.1016/j.clim.2017.05.017
Publikováno v:
Biochemical Society Transactions. 45:845-854
Sustained cellular signalling originated from the receptors located at the plasma membrane is widely associated with cancer susceptibility. Endosomal sorting and degradation of the cell surface receptors is therefore crucial to preventing chronic dow
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8f92ced20d95fa5eabab1b6862b7e6e0
https://doi.org/10.1042/bst20160332
https://doi.org/10.1042/bst20160332
Autor:
Artur Kania, Arnim Pause, Halil Bagci, Daniel Morales, Sylvie Lahaie, Avihu Klar, Guillaume Desrochers, Noumeira Hamoud, Anne-Claude Gingras, Charles-Etienne Castonguay, Jalal M. Kazan, Jean-François Côté
Publikováno v:
Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-19 (2019)
Scientific Reports, Vol 9, Iss 1, Pp 1-19 (2019)
The signalling output of many transmembrane receptors that mediate cell-cell communication is restricted by the endosomal sorting complex required for transport (ESCRT), but the impact of this machinery on Eph tyrosine kinase receptor function is unk
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::393e2729cdd7143402297351e7121f20
https://doi.org/10.1038/s41598-019-48421-9
https://doi.org/10.1038/s41598-019-48421-9