Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Jakub Zahumenský"'
Autor:
Maria Balazova, Petra Vesela, Lenka Babelova, Ivana Durisova, Paulina Kanovicova, Jakub Zahumensky, Jan Malinsky
Publikováno v:
Microbiology Spectrum, Vol 10, Iss 6 (2022)
ABSTRACT The absence of Isc1, the yeast homologue of mammalian neutral sphingomyelinase type 2, leads to severe mitochondrial dysfunction. We show that the deletion of another type C phospholipase, the phosphatidylglycerol (PG)-specific phospholipase
Externí odkaz:
https://doaj.org/article/c88b5cd984a24e3895f7ed9c633abd3b
Autor:
Katarina Vaskovicova, Petra Vesela, Jakub Zahumensky, Dagmar Folkova, Maria Balazova, Jan Malinsky
Publikováno v:
Biomolecules, Vol 10, Iss 11, p 1476 (2020)
Membrane proteins are targeted not only to specific membranes in the cell architecture, but also to distinct lateral microdomains within individual membranes to properly execute their biological functions. Yeast tetraspan protein Nce102 has been show
Externí odkaz:
https://doaj.org/article/ae7b3410a1b74050a45e24ee8b770849
Autor:
Jakub Zahumensky, Jan Malinsky
Publikováno v:
Biomolecules, Vol 9, Iss 8, p 305 (2019)
One of the best characterized fungal membrane microdomains is the MCC/eisosome. The MCC (membrane compartment of Can1) is an evolutionarily conserved ergosterol-rich plasma membrane domain. It is stabilized on its cytosolic face by the eisosome, a he
Externí odkaz:
https://doaj.org/article/036d50fbe27d4301b8ed3dd7fce3fba8
Autor:
Shamoon Naseem, Jakub Zahumenský, Carla E. Lanze, Lois M. Douglas, Jan Malínský, James B. Konopka
Publikováno v:
mSphere, Vol 9, Iss 12 (2024)
ABSTRACT The plasma membrane is critical for the virulence of the human fungal pathogen Candida albicans. In addition to functioning as a protective barrier, the plasma membrane plays dynamic roles in a wide range of functions needed for virulence in
Externí odkaz:
https://doaj.org/article/c34ccab149d844f982cdac1a2acaf5c8
Autor:
Jakub Zahumenský, Caroline Mota Fernandes, Petra Veselá, Maurizio Del Poeta, James B. Konopka, Jan Malínský
Publikováno v:
Microbiology Spectrum, Vol 10, Iss 4 (2022)
ABSTRACT Sphingolipids are essential building blocks of eukaryotic membranes and important signaling molecules that are regulated tightly in response to environmental and physiological inputs. While their biosynthetic pathway has been well-described,
Externí odkaz:
https://doaj.org/article/aeacbcde1ecf440c98ec1449610fafdd
Publikováno v:
Heliyon, Vol 10, Iss 19, Pp e38786- (2024)
The regulation of gene expression in eukaryotes relies largely on the action of exoribonucleases, evolutionarily conserved enzymes that digest decapped messenger RNAs in the 5’-3’ direction. The activity of Xrn1, the major yeast exoribonuclease,
Externí odkaz:
https://doaj.org/article/781c4d9aaab1450ba2847db64ed2e26d
Autor:
Paulína Káňovičová, Petra Čermáková, Dominika Kubalová, Lenka Bábelová, Petra Veselá, Martin Valachovič, Jakub Zahumenský, Anton Horváth, Jan Malínský, Mária Balážová
Publikováno v:
The Journal of Biological Chemistry
Barth syndrome (BTHS) is an inherited mitochondrial disorder characterized by a decrease in total cardiolipin and the accumulation of its precursor monolysocardiolipin due to the loss of the transacylase enzyme tafazzin. However, the molecular basis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dde4a52087aa3b610bb0be1c6a81a9d6
https://doi.org/10.1016/j.jbc.2021.101462
https://doi.org/10.1016/j.jbc.2021.101462
Autor:
Tereza Filipi, Zuzana Matusova, Pavel Abaffy, Ondrej Vanatko, Jana Tureckova, Sarka Benesova, Monika Kubiskova, Denisa Kirdajova, Jakub Zahumensky, Lukas Valihrach, Miroslava Anderova
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-15 (2023)
Abstract The role of glia in amyotrophic lateral sclerosis (ALS) is undeniable. Their disease-related activity has been extensively studied in the spinal cord, but only partly in the brain. We present herein a comprehensive study of glia in the corte
Externí odkaz:
https://doaj.org/article/a35f615333f640c2a67600c1ef38b273
Publikováno v:
FEMS Yeast Research. 17
Multidrug transporters are often responsible for failure of medical treatment, since they expel a variety of structurally and functionally unrelated drugs out of the cell. We found that the fluorescent probe diS-C3(3) is a substrate of not only Pdr5p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e8dcd33fcad683097fe643f980880ac
https://doi.org/10.1093/femsyr/fox073
https://doi.org/10.1093/femsyr/fox073
Autor:
Karel Sigler, Andrea Svenkrtova, Otakar Hlaváček, Dana Gášková, Tomáš Hendrych, Iva Jančíková, Jakub Zahumenský, Jaromír Plášek, Andrea Drietomská
Publikováno v:
Biochimica et biophysica acta. Biomembranes. 1859(10)
Tok1p is a highly specific yeast plasma membrane potassium channel with strong outward directionality. Its opening is induced by membrane depolarization. Although the biophysical properties of Tok1p are well-described, its potentially important physi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ba1af3649fff15eb017e3a209d5ff79
https://pubmed.ncbi.nlm.nih.gov/28669766
https://pubmed.ncbi.nlm.nih.gov/28669766