Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Jakub Svenda"'
Autor:
Kamal Kumar, Herbert Waldmann, Lea Kremer, Lukas Maier, Carsten Strohmann, Jonathan O. Bauer, Slava Ziegler, Michael Sheremet, Jakub Svenda
Publikováno v:
Angewandte Chemie International Edition. 54:5596-5602
Biology-oriented synthesis employs the structural information encoded in complex natural products to guide the synthesis of compound collections enriched in bioactivity. The trans-hydrindane dehydro-δ-lactone motif defines the characteristic scaffol
Publikováno v:
Proceedings of the National Academy of Sciences. 108:6709-6714
Many first-line cancer drugs are natural products or are derived from them by chemical modification. The trioxacarcins are an emerging class of molecules of microbial origin with potent antiproliferative effects, which may derive from their ability t
Autor:
Jakub Svenda, Andrew G. Myers
Publikováno v:
Organic Letters. 11:2437-2440
Methyl alpha-methylene-beta-tert-butyldimethylsilyloxycarboxylate esters are found to undergo diastereoselective epoxidation in the presence of potassium tert-butoxide-tert-butyl hydroperoxide to form anti products. In an effort to better understand
Publikováno v:
Organic letters. 14(7)
Two routes to the 2,6-dideoxysugar methyl trioxacarcinoside A are described. Each was enabled by an apparent α-chelation-controlled addition of an allylmetal reagent to a ketone substrate containing a free α-hydroxyl group and a β-hydroxyl substit
Autor:
John F, Bower, Jakub, Svenda, Andrew J, Williams, Jonathan P H, Charmant, Ron M, Lawrence, Peter, Szeto, Timothy, Gallagher
Publikováno v:
Organic letters. 6(25)
[reaction: see text] A structurally diverse series of mono- and disubstituted 1,2- and 1,3-cyclic sulfamidates react with stabilized enolates, including malonate and phosphonoacetate variants, to provide, after lactamization, substituted and alpha-fu