Zobrazeno 1 - 10
of 88
pro vyhledávání: '"Jakub Rohlena"'
Autor:
Pankaj Sharma, Elena Maklashina, Markus Voehler, Sona Balintova, Sarka Dvorakova, Michal Kraus, Katerina Hadrava Vanova, Zuzana Nahacka, Renata Zobalova, Stepana Boukalova, Kristyna Cunatova, Tomas Mracek, Hans K. Ghayee, Karel Pacak, Jakub Rohlena, Jiri Neuzil, Gary Cecchini, T. M. Iverson
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Complex II (CII) activity controls phenomena that require crosstalk between metabolism and signaling, including neurodegeneration, cancer metabolism, immune activation, and ischemia-reperfusion injury. CII activity can be regulated at the le
Externí odkaz:
https://doaj.org/article/a63f5096183a4241a866d4154beb8b16
Autor:
Zora Novakova, Mirko Milosevic, Zsofia Kutil, Marketa Ondrakova, Barbora Havlinova, Petr Kasparek, Cristian Sandoval-Acuña, Zuzana Korandova, Jaroslav Truksa, Marek Vrbacky, Jakub Rohlena, Cyril Barinka
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-17 (2022)
Abstract In humans, disruptions in the heme biosynthetic pathway are associated with various types of porphyrias, including variegate porphyria that results from the decreased activity of protoporphyrinogen oxidase IX (PPO; E.C.1.3.3.4), the enzyme c
Externí odkaz:
https://doaj.org/article/c8c3edc54eb849c18d405c9c691a81f8
Autor:
Zuzana Bielcikova, Jan Stursa, Ludmila Krizova, Lanfeng Dong, Jan Spacek, Stanislav Hlousek, Michal Vocka, Katerina Rohlenova, Olga Bartosova, Vladimir Cerny, Tomas Padrta, Michal Pesta, Pavel Michalek, Sona Stemberkova Hubackova, Katarina Kolostova, Eliska Pospisilova, Vladimir Bobek, Peter Klezl, Renata Zobalova, Berwini Endaya, Jakub Rohlena, Lubos Petruzelka, Lukas Werner, Jiri Neuzil
Publikováno v:
EClinicalMedicine, Vol 57, Iss , Pp 101873- (2023)
Summary: Background: Mitochondria present an emerging target for cancer treatment. We have investigated the effect of mitochondrially targeted tamoxifen (MitoTam), a first-in-class anti-cancer agent, in patients with solid metastatic tumours. Methods
Externí odkaz:
https://doaj.org/article/91ab15755d5b4f4c9326f015bc30ba5c
Publikováno v:
Cancers, Vol 15, Iss 18, p 4476 (2023)
A recent paper published in Nature Medicine reported on the Phase I clinical trial of a mitochondria-targeting anti-cancer agent IACS-01059 in patients with acute myeloid leukemia (AML) and solid tumors [...]
Externí odkaz:
https://doaj.org/article/50db9fdb6acc45ae9e63d8d3d91c68b4
Autor:
Petra Hyroššová, Mirko Milošević, Josef Škoda, Jiří Vachtenheim Jr, Jakub Rohlena, Kateřina Rohlenová
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Targeting tumor metabolism for cancer therapy is an old strategy. In fact, historically the first effective cancer therapeutics were directed at nucleotide metabolism. The spectrum of metabolic drugs considered in cancer increases rapidly – clinica
Externí odkaz:
https://doaj.org/article/7f3eb304ecb0414fb421b1c7b882e62f
Autor:
Alessia Roma, Matthew Tcheng, Nawaz Ahmed, Sarah Walker, Preethi Jayanth, Mark D. Minden, Julie A. Reisz, Angelo D'Alessandro, Jakub Rohlena, Paul A. Spagnuolo
Publikováno v:
Phytomedicine Plus, Vol 2, Iss 3, Pp 100300- (2022)
Background: Acute myeloid leukemia (AML) is a hematopoietic malignancy that results from the accumulation of undifferentiated myeloid cells in the peripheral blood and bone marrow. Limited therapeutics contribute to unfavorable patient outcomes, high
Externí odkaz:
https://doaj.org/article/d6cba8b6f3d64bb79a2161045226f5c7
Autor:
Verena Henrichs, Lenka Grycova, Cyril Barinka, Zuzana Nahacka, Jiri Neuzil, Stefan Diez, Jakub Rohlena, Marcus Braun, Zdenek Lansky
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Intracellular trafficking of organelles is driven by kinesin-1 stepping along microtubules, but crowding conditions impede kinesin-1 motility. Here authors demonstrate that TRAK1, an adaptor protein essential for mitochondrial trafficking, activates
Externí odkaz:
https://doaj.org/article/100a9a30842b49bfb6e6362c1f4832c1
Publikováno v:
Redox Report, Vol 25, Iss 1, Pp 26-32 (2020)
Increasing evidence points to the respiratory Complex II (CII) as a source and modulator of reactive oxygen species (ROS). Both functional loss of CII as well as its pharmacological inhibition can lead to ROS generation in cells, with a relevant impa
Externí odkaz:
https://doaj.org/article/67b2efa0763044b29ab37ab24fcd3cd6
Autor:
Ayenachew Bezawork-Geleta, He Wen, LanFeng Dong, Bing Yan, Jelena Vider, Stepana Boukalova, Linda Krobova, Katerina Vanova, Renata Zobalova, Margarita Sobol, Pavel Hozak, Silvia Magalhaes Novais, Veronika Caisova, Pavel Abaffy, Ravindra Naraine, Ying Pang, Thiri Zaw, Ping Zhang, Radek Sindelka, Mikael Kubista, Steven Zuryn, Mark P. Molloy, Michael V. Berridge, Karel Pacak, Jakub Rohlena, Sunghyouk Park, Jiri Neuzil
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
Mitochondrial complex II is normally composed of four subunits. Here the authors show that bioenergetic stress conditions give rise to a partially assembled variant of complex II, which shifts the anabolic pathways to less energy demanding processes.
Externí odkaz:
https://doaj.org/article/762a6e8dd0c245dd8c980ced8121b927
Autor:
Lan-Feng Dong, Jaromira Kovarova, Martina Bajzikova, Ayenachew Bezawork-Geleta, David Svec, Berwini Endaya, Karishma Sachaphibulkij, Ana R Coelho, Natasa Sebkova, Anna Ruzickova, An S Tan, Katarina Kluckova, Kristyna Judasova, Katerina Zamecnikova, Zuzana Rychtarcikova, Vinod Gopalan, Ladislav Andera, Margarita Sobol, Bing Yan, Bijay Pattnaik, Naveen Bhatraju, Jaroslav Truksa, Pavel Stopka, Pavel Hozak, Alfred K Lam, Radislav Sedlacek, Paulo J Oliveira, Mikael Kubista, Anurag Agrawal, Katerina Dvorakova-Hortova, Jakub Rohlena, Michael V Berridge, Jiri Neuzil
Publikováno v:
eLife, Vol 6 (2017)
Recently, we showed that generation of tumours in syngeneic mice by cells devoid of mitochondrial (mt) DNA (ρ0 cells) is linked to the acquisition of the host mtDNA. However, the mechanism of mtDNA movement between cells remains unresolved. To deter
Externí odkaz:
https://doaj.org/article/4285105d6a3d4ae5a57e35604fc4c03d