Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Jakub Otwinowski"'
Autor:
Colin LaMont, Jakub Otwinowski, Kanika Vanshylla, Henning Gruell, Florian Klein, Armita Nourmohammad
Publikováno v:
eLife, Vol 11 (2022)
Infusion of broadly neutralizing antibodies (bNAbs) has shown promise as an alternative to anti-retroviral therapy against HIV. A key challenge is to suppress viral escape, which is more effectively achieved with a combination of bNAbs. Here, we prop
Externí odkaz:
https://doaj.org/article/86a8df6aeacc4e3fb7de5ecd0db0f68b
Autor:
Nicholas C. Wu, Jakub Otwinowski, Andrew J. Thompson, Corwin M. Nycholat, Armita Nourmohammad, Ian A. Wilson
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
Antigenic site B in influenza A virus hemagglutinin (HA) is immunodominant in circulating human H3N2 strains. Using deep mutational scanning, Wu et al. here define the local fitness landscapes of HA antigenic site B in six human H3N2 strains, providi
Externí odkaz:
https://doaj.org/article/78bbd94e04ac49b8926eabf56d6fbb17
Publikováno v:
Entropy, Vol 22, Iss 9, p 967 (2020)
Evolutionary algorithms, inspired by natural evolution, aim to optimize difficult objective functions without computing derivatives. Here we detail the relationship between classical population genetics of quantitative traits and evolutionary optimiz
Externí odkaz:
https://doaj.org/article/75c5b89c2132402a8ee0863f69688341
Publikováno v:
PLoS Genetics, Vol 12, Iss 7, p e1006171 (2016)
The vertebrate adaptive immune system provides a flexible and diverse set of molecules to neutralize pathogens. Yet, viruses such as HIV can cause chronic infections by evolving as quickly as the adaptive immune system, forming an evolutionary arms r
Externí odkaz:
https://doaj.org/article/941cc82c0ce341a2b9957ec9802b0edf
Autor:
Jakub Otwinowski, Ilya Nemenman
Publikováno v:
PLoS ONE, Vol 8, Iss 5, p e61570 (2013)
Genotype-to-phenotype maps and the related fitness landscapes that include epistatic interactions are difficult to measure because of their high dimensional structure. Here we construct such a map using the recently collected corpora of high-throughp
Externí odkaz:
https://doaj.org/article/022c865a42d24bbcbbf487079ff81ced
Autor:
Michael N. Pun, Andrew Ivanov, Quinn Bellamy, Zachary Montague, Colin LaMont, Philip Bradley, Jakub Otwinowski, Armita Nourmohammad
Proteins play a central role in biology from immune recognition to brain activity. While major advances in machine learning have improved our ability to predict protein structure from sequence, determining protein function from structure remains a ma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef858fc37c732ac75f507b3ab39b6d64
Autor:
Jakub Otwinowski, Corwin M. Nycholat, Armita Nourmohammad, Nicholas C. Wu, Andrew J. Thompson, Ian A. Wilson
Publikováno v:
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
Nature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
Antigenic drift of influenza virus hemagglutinin (HA) is enabled by facile evolvability. However, HA antigenic site B, which has become immunodominant in recent human H3N2 influenza viruses, is also evolutionarily constrained by its involvement in re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78320ee26a5c38a6fe83a7e4bec17595
https://pubmed.ncbi.nlm.nih.gov/32144244
https://pubmed.ncbi.nlm.nih.gov/32144244
Autor:
William S DeWitt, Jakub Otwinowski, Owen Tak Yin Tsang, Huibin Lv, Meng Yuan, Giulio Isacchini, Armita Nourmohammad, Zachary Montague, J. S. Malik Peiris, Chris Ka Pun Mok, Hejun Liu, Ian A. Wilson, Garrick K. Yip, Nicholas C. Wu, Wilson W. Ng
Publikováno v:
Cell Reports
Cell Reports, Elsevier Inc, 2021, 35 (8), pp.109173. ⟨10.1016/j.celrep.2021.109173⟩
medRxiv
Cell Reports, Elsevier Inc, 2021, 35 (8), pp.109173. ⟨10.1016/j.celrep.2021.109173⟩
medRxiv
Individuals with the 2019 coronavirus disease (COVID-19) show varying severity of the disease, ranging from asymptomatic to requiring intensive care. Although monoclonal antibodies specific to the severe acute respiratory syndrome coronavirus 2 (SARS
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc508f71cd97bfc3c164745b8a7c819e
https://doi.org/10.1016/j.celrep.2021.109173
https://doi.org/10.1016/j.celrep.2021.109173
Publikováno v:
Molecular Biology and Evolution
Molecular Biology and Evolution, Oxford University Press (OUP), 2019, 36 (10), pp.2184-2194. ⟨10.1093/molbev/msz143⟩
Molecular Biology and Evolution, Oxford University Press (OUP), 2019, 36 (10), pp.2184-2194. ⟨10.1093/molbev/msz143⟩
During chronic infection, HIV-1 engages in a rapid coevolutionary arms race with the host’s adaptive immune system. While it is clear that HIV exerts strong selection on the adaptive immune system, the characteristics of the somatic evolution that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1169173faeb38305f26fdc3696d5c375
http://arxiv.org/abs/1802.08841
http://arxiv.org/abs/1802.08841