Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Jakub Orzechowski Westholm"'
Publikováno v:
iScience, Vol 27, Iss 9, Pp 110659- (2024)
Summary: All organisms have to carefully regulate their gene expression, not least during development. mRNA levels are often used as proxy for protein output; however, this approach ignores post-transcriptional effects. In particular, mRNA-protein co
Externí odkaz:
https://doaj.org/article/8d514976a5f341399508fe621d9bce66
Autor:
Ammar Zaghlool, Adnan Niazi, Åsa K. Björklund, Jakub Orzechowski Westholm, Adam Ameur, Lars Feuk
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract Transcriptome analysis has mainly relied on analyzing RNA sequencing data from whole cells, overlooking the impact of subcellular RNA localization and its influence on our understanding of gene function, and interpretation of gene expression
Externí odkaz:
https://doaj.org/article/9a91b169ba164e37b3d0b15f348a8368
Autor:
Helena Sork, Mariana Conceicao, Giulia Corso, Joel Nordin, Yi Xin Fiona Lee, Kaarel Krjutskov, Jakub Orzechowski Westholm, Pieter Vader, Marie Pauwels, Roosmarijn E. Vandenbroucke, Matthew JA Wood, Samir EL Andaloussi, Imre Mäger
Publikováno v:
Cells, Vol 10, Iss 6, p 1543 (2021)
The extracellular environment consists of a plethora of molecules, including extracellular miRNA that can be secreted in association with extracellular vesicles (EVs) or soluble protein complexes (non-EVs). Yet, interest in therapeutic short RNA carr
Externí odkaz:
https://doaj.org/article/ae8e38fcc6d84a959bd9d3253b00dd47
Autor:
Sanja Vickovic, Patrik L. Ståhl, Fredrik Salmén, Sarantis Giatrellis, Jakub Orzechowski Westholm, Annelie Mollbrink, José Fernández Navarro, Joaquin Custodio, Magda Bienko, Lesley-Ann Sutton, Richard Rosenquist, Jonas Frisén, Joakim Lundeberg
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-9 (2016)
Currently available single-cell transcriptomic analyses are expensive and low throughput. Here, Vickovicet al. describe a new method called MASC-seq that is based on microarray barcoding of expression pattern and of low cost with high robustness.
Externí odkaz:
https://doaj.org/article/d8f2089612d04d53851c2f9124db5c0b
Autor:
Niklas Nordberg, Ida Olsson, Mattias Carlsson, Guo-Zhen Hu, Jakub Orzechowski Westholm, Hans Ronne
Publikováno v:
PLoS ONE, Vol 9, Iss 7, p e95078 (2014)
Rph1 and Gis1 are two related yeast zinc finger proteins that function as downstream effectors in the Ras/PKA, TOR and Sch9 nutrient signaling pathways. Both proteins also contain JmjC histone demethylase domains, but only Rph1 is known to be an acti
Externí odkaz:
https://doaj.org/article/f3626bbdd9d64fa284bc10633e7e8703
Autor:
Kailiang Sun, Jakub Orzechowski Westholm, Kazuya Tsurudome, Joshua W Hagen, Yubing Lu, Minoree Kohwi, Doron Betel, Fen-Biao Gao, A Pejmun Haghighi, Chris Q Doe, Eric C Lai
Publikováno v:
PLoS Genetics, Vol 8, Iss 2, p e1002515 (2012)
miR-124 is conserved in sequence and neuronal expression across the animal kingdom and is predicted to have hundreds of mRNA targets. Diverse defects in neural development and function were reported from miR-124 antisense studies in vertebrates, but
Externí odkaz:
https://doaj.org/article/2dc79ea36ad24fe7bab34e6b25d87eba
Autor:
Jakub Orzechowski Westholm, Susanna Tronnersjö, Niklas Nordberg, Ida Olsson, Jan Komorowski, Hans Ronne
Publikováno v:
PLoS ONE, Vol 7, Iss 2, p e31577 (2012)
Aging in organisms as diverse as yeast, nematodes, and mammals is delayed by caloric restriction, an effect mediated by the nutrient sensing TOR, RAS/cAMP, and AKT/Sch9 pathways. The transcription factor Gis1 functions downstream of these pathways in
Externí odkaz:
https://doaj.org/article/01445a9169cc42c5a7c83deb59272869
Publikováno v:
Hippocampus. 33:391-401
Hippocampal adult neural stem cells emerge from progeny of the neuroepithelial lineage during murine brain development. Hippocampus development is increasingly well understood. However, the clonal relationships between early neuroepithelial stem cell
Autor:
Yuvarani Masarapu, Egle Cekanaviciute, Zaneta Andrusivova, Jakub Orzechowski Westholm, Åsa Björklund, Robin Fallegger, Pau Badia-i-Mompel, Valery Boyko, Shubha Vasisht, Amanda Saravia-Butler, Samrawit Gebre, Enikö Lázár, Olaf Bergmann, Deanne Taylor, Douglas Wallace, Christer Sylvén, Julio Saez Rodriguez, Jonathan Galazka, Sylvain Costes, Stefania Giacomello
Impairment of the central nervous system (CNS) functions in astronauts is a major health risk for long-duration space missions. Here, for the first time, we combine single-cell multiomics (transcriptomics and chromatin accessibility) and spatial tran
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::67f890e7ac91f2287d9d35893fcba5bb
https://doi.org/10.21203/rs.3.rs-2865086/v1
https://doi.org/10.21203/rs.3.rs-2865086/v1
Autor:
Leonie von Berlin, Michael Ratz, Jonas Frisén, Jakub Orzechowski Westholm, Marcel Martin, Gioele La Manno, Joakim Lundeberg, Ludvig Larsson
SummaryThe mammalian brain contains a large number of specialized cells that develop from a thin sheet of neuroepithelial progenitor cells1,2. Recently, high throughput single-cell technologies have been used to define the molecular diversity of hund
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d33a468eb942c5c0a8b4cda31bc43db2
https://doi.org/10.1101/2021.08.31.458418
https://doi.org/10.1101/2021.08.31.458418