Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Jakub O, Westholm"'
Autor:
Vivian Lobo, Evgeniia Shcherbinina, Jakub O. Westholm, Iwona Nowak, Hsiang-Chi Huang, Davide Angeletti, Dimitrios G. Anastasakis, Aishe A. Sarshad
Publikováno v:
Scientific Data, Vol 11, Iss 1, Pp 1-12 (2024)
Abstract In this study we examine the impact of cell confluency on gene expression. We focused on Argonaute (AGO) protein dynamics and associated gene and protein expression in HEK293, A375, and SHSY5Y cell lines. As a consequence of cell confluency,
Externí odkaz:
https://doaj.org/article/f6aebf60276846c7a605cfd3bfe3b5c2
Autor:
Yuvarani Masarapu, Egle Cekanaviciute, Zaneta Andrusivova, Jakub O. Westholm, Åsa Björklund, Robin Fallegger, Pau Badia-i-Mompel, Valery Boyko, Shubha Vasisht, Amanda Saravia-Butler, Samrawit Gebre, Enikő Lázár, Marta Graziano, Solène Frapard, Robert G. Hinshaw, Olaf Bergmann, Deanne M. Taylor, Douglas C. Wallace, Christer Sylvén, Konstantinos Meletis, Julio Saez-Rodriguez, Jonathan M. Galazka, Sylvain V. Costes, Stefania Giacomello
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Impairment of the central nervous system (CNS) poses a significant health risk for astronauts during long-duration space missions. In this study, we employed an innovative approach by integrating single-cell multiomics (transcriptomics and c
Externí odkaz:
https://doaj.org/article/e005e5c2fdd54d54a58a469fc7aa1cbf
Autor:
Bożena Bruhn-Olszewska, Hanna Davies, Daniil Sarkisyan, Ulana Juhas, Edyta Rychlicka-Buniowska, Magdalena Wójcik, Monika Horbacz, Marcin Jąkalski, Paweł Olszewski, Jakub O. Westholm, Agata Smialowska, Karol Wierzba, Åsa Torinsson Naluai, Niklas Jern, Lars-Magnus Andersson, Josef D. Järhult, Natalia Filipowicz, Eva Tiensuu Janson, Sten Rubertsson, Miklós Lipcsey, Magnus Gisslén, Michael Hultström, Robert Frithiof, Jan P. Dumanski
Publikováno v:
Genome Medicine, Vol 14, Iss 1, Pp 1-14 (2022)
Abstract Background The COVID-19 pandemic, which has a prominent social and economic impact worldwide, shows a largely unexplained male bias for the severity and mortality of the disease. Loss of chromosome Y (LOY) is a risk factor candidate in COVID
Externí odkaz:
https://doaj.org/article/47e00c830df04f0b876d13cf816381e5
Autor:
Anna M.L. Coenen-Stass, Helena Sork, Sole Gatto, Caroline Godfrey, Amarjit Bhomra, Kaarel Krjutškov, Jonathan R. Hart, Jakub O. Westholm, Liz O’Donovan, Andreas Roos, Hanns Lochmüller, Pier Lorenzo Puri, Samir EL Andaloussi, Matthew J.A. Wood, Thomas C. Roberts
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 13, Iss , Pp 1-15 (2018)
Extracellular small RNAs (sRNAs), including microRNAs (miRNAs), are promising biomarkers for diseases such as Duchenne muscular dystrophy (DMD), although their biological relevance is largely unknown. To investigate the relationship between intracell
Externí odkaz:
https://doaj.org/article/dc55244590fd44329400bbee0db3a420
Autor:
Jakub O. Westholm, Pedro Miura, Sara Olson, Sol Shenker, Brian Joseph, Piero Sanfilippo, Susan E. Celniker, Brenton R. Graveley, Eric C. Lai
Publikováno v:
Cell Reports, Vol 9, Iss 5, Pp 1966-1980 (2014)
Summary: Circularization was recently recognized to broadly expand transcriptome complexity. Here, we exploit massive Drosophila total RNA-sequencing data, >5 billion paired-end reads from >100 libraries covering diverse developmental stages, tissues
Externí odkaz:
https://doaj.org/article/fe79549a28ff41f09b8c144dc74c610f
Autor:
Peter Smibert, Pedro Miura, Jakub O. Westholm, Sol Shenker, Gemma May, Michael O. Duff, Dayu Zhang, Brian D. Eads, Joe Carlson, James B. Brown, Robert C. Eisman, Justen Andrews, Thomas Kaufman, Peter Cherbas, Susan E. Celniker, Brenton R. Graveley, Eric C. Lai
Publikováno v:
Cell Reports, Vol 1, Iss 3, Pp 277-289 (2012)
We analyzed the usage and consequences of alternative cleavage and polyadenylation (APA) in Drosophila melanogaster by using >1 billion reads of stranded mRNA-seq across a variety of dissected tissues. Beyond demonstrating that a majority of fly tran
Externí odkaz:
https://doaj.org/article/284d5c71c22741fdbc558274abeb334a
Autor:
Peter Smibert, Pedro Miura, Jakub O. Westholm, Sol Shenker, Gemma May, Michael O. Duff, Dayu Zhang, Brian D. Eads, Joe Carlson, James B. Brown, Robert C. Eisman, Justen Andrews, Thomas Kaufman, Peter Cherbas, Susan E. Celniker, Brenton R. Graveley, Eric C. Lai
Publikováno v:
Cell Reports, Vol 3, Iss 3, p 969 (2013)
Externí odkaz:
https://doaj.org/article/c9c98bce815640bd830f0e5ca4bd156d
Autor:
Liqun, Yao, Shenqiu, Wang, Jakub O, Westholm, Qi, Dai, Ryo, Matsuda, Chie, Hosono, Sarah, Bray, Eric C, Lai, Christos, Samakovlis
Publikováno v:
Development (Cambridge, England). 144(17)
Grainy head (Grh) is a conserved transcription factor (TF) controlling epithelial differentiation and regeneration. To elucidate Grh functions we identified embryonic Grh targets by ChIP-seq and gene expression analysis. We show that Grh controls hun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::868927e9435b4bbd95fe2465953cd6ad
https://pubmed.ncbi.nlm.nih.gov/28760809
https://pubmed.ncbi.nlm.nih.gov/28760809