Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Jakub M. Swiercz"'
Autor:
Rui Xu, Carsten Höß, Jakub M. Swiercz, Dominique T. Brandt, Veronika Lutz, Natalia Petersen, Rui Li, Dandan Zhao, Arkadiusz Oleksy, Tilbe Creigh-Pulatmen, Martina Trokter, Marina Fedorova, Ann Atzberger, Rune B. Strandby, August A. Olsen, Michael P. Achiam, David Matthews, Magdalena Huber, Hermann-Josef Gröne, Stefan Offermanns, Thomas Worzfeld
Publikováno v:
Science translational medicine. 14(654)
Peptic ulcer disease is a frequent clinical problem with potentially serious complications such as bleeding or perforation. A decisive factor in the pathogenesis of peptic ulcers is gastric acid, the secretion of which is controlled by the hormone ga
Publikováno v:
PLoS ONE, Vol 9, Iss 8, p e105661 (2014)
Plexins are widely expressed transmembrane proteins that mediate the cellular effects of semaphorins. The molecular mechanisms of plexin-mediated signal transduction are still poorly understood. Here we show that signalling via B-family plexins leadi
Externí odkaz:
https://doaj.org/article/39f04672d825470e9f38d98e6632baf9
Autor:
Jakub M. Swiercz, Daniel Heil, Hendrik Nolte, Moritz Bünemann, Marie-Josée Santoni, Ramesh K. Krishnan, Jenny Pestel, Mario Looso, Lida Yang, Thomas Worzfeld, Stefan Offermanns, Jean-Paul Borg, Harmandeep Kaur, Tianliang Sun, Cornelius Krasel
Publikováno v:
Journal of Cell Biology
Journal of Cell Biology, Rockefeller University Press, 2017, 216 (1), pp.199-215. ⟨10.1083/jcb.201602002⟩
Journal of Cell Biology, 2017, 216 (1), pp.199-215. ⟨10.1083/jcb.201602002⟩
The Journal of Cell Biology
Journal of Cell Biology, Rockefeller University Press, 2017, 216 (1), pp.199-215. ⟨10.1083/jcb.201602002⟩
Journal of Cell Biology, 2017, 216 (1), pp.199-215. ⟨10.1083/jcb.201602002⟩
The Journal of Cell Biology
Semaphorins are ligands for their receptors, plexins. In this study, Sun et al. show that a transmembrane semaphorin, Sema4A, transduces signals in a reverse manner to control migration of cancer and dendritic cells via the cell polarity protein Scri
Autor:
Thomas Worzfeld, Jakub M. Swiercz
Publikováno v:
Methods in Molecular Biology ISBN: 9781493964468
Plexins comprise a family of transmembrane receptors for semaphorins. Plexins of the B- and D-subfamily interact with the receptor tyrosine kinase ErbB-2, and this interaction has been shown to be functionally relevant for various biological processe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f6f1f32c53e2c35cfbdda9ca2efe950f
https://doi.org/10.1007/978-1-4939-6448-2_9
https://doi.org/10.1007/978-1-4939-6448-2_9
Autor:
Thomas, Worzfeld, Jakub M, Swiercz
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 1493
Plexins comprise a family of transmembrane receptors for semaphorins. Plexins of the B- and D-subfamily interact with the receptor tyrosine kinase ErbB-2, and this interaction has been shown to be functionally relevant for various biological processe
Autor:
Joachim Wittbrodt, Felix Loosli, Stefan Offermanns, Cathrin Herder, Rebecca Quiring, Jakub M. Swiercz, Ravindra Peravali, Claudia Müller
Publikováno v:
Development. 140:2787-2797
The vertebrate central nervous system develops from an epithelium where cells are polarized along the apicobasal axis. Loss of this polarity results in abnormal organ architecture, morphology and proliferation. We found that mutations of the guanine
Autor:
Thomas Worzfeld, Stefan Offermanns, Jakub M. Swiercz, Beate K. Straub, Kishor K. Sivaraj, Mario Looso
Publikováno v:
Journal of Clinical Investigation. 122:1296-1305
Diagnosis of metastatic breast cancer is associated with a very poor prognosis. New therapeutic targets are urgently needed, but their development is hampered by a lack of understanding of the mechanisms leading to tumor metastasis. Exemplifying this
Autor:
Martin Schneider, Charlotte Rolny, Mauro Risio, Jakub M. Swiercz, Claus Christensen, Andrea Casazza, Andrea Bertotti, Ivana Sarotto, Sabrina Rizzolio, Luca Tamagnone, Paolo M. Comoglio, Livio Trusolino, Veronica Finisguerra, Massimiliano Mazzone, Jürgen Weitz, Lorena Capparuccia, Andrea Camperi
Publikováno v:
Journal of Clinical Investigation; Vol 120
Semaphorin 3E (Sema3E) is a secreted molecule implicated in axonal path finding and inhibition of developmental and postischemic angiogenesis. Sema3E is also highly expressed in metastatic cancer cells, but its mechanistic role in tumor progression w
Publikováno v:
Molecular and Cellular Biology. 29:6321-6334
The semaphorin 4D (Sema4D) receptor plexin-B1 constitutively interacts with particular Rho guanine nucleotide exchange factors (RhoGEFs) and thereby mediates Sema4D-induced RhoA activation, a process which involves the tyrosine phosphorylation of ple
Autor:
Alexandra Hirschberg, Jakub M. Swiercz, Rohini Kuner, Suhua Deng, Stefan Offermanns, Alexander Korostylev, Luca Tamagnone, Thomas Worzfeld, Pietro Fazzari, Peter Vodrazka
Publikováno v:
European Journal of Neuroscience. 30:1193-1208
Semaphorins and their receptors, plexins, have emerged as key regulators of various aspects of neuronal development. In contrast to the Plexin-A family, the cellular functions of Plexin-B family proteins in developing neurons are only poorly understo