Zobrazeno 1 - 10
of 55
pro vyhledávání: '"Jakub Jończyk"'
Publikováno v:
Biomolecules, Vol 14, Iss 7, p 797 (2024)
The main protease (Mpro) of SARS-CoV-2 is an essential enzyme that plays a critical part in the virus’s life cycle, making it a significant target for developing antiviral drugs. The inhibition of SARS-CoV-2 Mpro has emerged as a promising approach
Externí odkaz:
https://doaj.org/article/1a6dd54d6a764ca385ba6a085067946b
Autor:
Kamila Czarnecka, Małgorzata Girek, Paweł Kręcisz, Robert Skibiński, Kamil Łątka, Jakub Jończyk, Marek Bajda, Piotr Szymczyk, Grzegorz Galita, Jacek Kabziński, Ireneusz Majsterek, Alba Espargaró, Raimon Sabate, Paweł Szymański
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 38, Iss 1 (2023)
Alzheimer’s disease (AD) is a progressive neurodegenerative brain disease. Thus, drugs including donepezil, rivastigmine, and galantamine are not entirely effective in the treatment of this multifactorial disease. The present study evaluates eight
Externí odkaz:
https://doaj.org/article/45d56f22c80743759b64fd4e3c5eda6c
Autor:
Natalia Szałaj, Justyna Godyń, Jakub Jończyk, Anna Pasieka, Dawid Panek, Tomasz Wichur, Krzysztof Więckowski, Paula Zaręba, Marek Bajda, Anja Pislar, Barbara Malawska, Raimon Sabate, Anna Więckowska
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 35, Iss 1, Pp 1944-1952 (2020)
Effective therapy of Alzheimer’s disease (AD) requires treatment with a combination of drugs that modulate various pathomechanisms contributing to the disease. In our research, we have focused on the development of multi-target-directed ligands –
Externí odkaz:
https://doaj.org/article/8664353705ab4c3dbfa4416d81bfa9d5
Autor:
Tomasz Kostrzewa, Jakub Jończyk, Joanna Drzeżdżon, Dagmara Jacewicz, Magdalena Górska-Ponikowska, Marcin Kołaczkowski, Alicja Kuban-Jankowska
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 13, p 7034 (2022)
One of the main goals of recent bioinorganic chemistry studies has been to design and synthesize novel substances to treat human diseases. The promising compounds are metal-based and metal ion binding components such as vanadium-based compounds. The
Externí odkaz:
https://doaj.org/article/9bb1c918558f4fc5b72830aa56892594
Autor:
Kamila Czarnecka, Małgorzata Girek, Karolina Maciejewska, Robert Skibiński, Jakub Jończyk, Marek Bajda, Jacek Kabziński, Przemysław Sołowiej, Ireneusz Majsterek, Paweł Szymański
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 33, Iss 1, Pp 158-170 (2018)
Alzheimer’s disease (AD) is the most common progressive form of brain neurodegeneration and the most prevailing cause of dementia. Unfortunately, the aetiology of AD is not completely studied but different factors are associated with the developmen
Externí odkaz:
https://doaj.org/article/ceb5be2cc9b04a48b2967c4cd91ccad8
Autor:
Jakub Jończyk, Jędrzej Kukułowicz, Kamil Łątka, Barbara Malawska, Young-Sik Jung, Kamil Musilek, Marek Bajda
Publikováno v:
Biomolecules, Vol 11, Iss 2, p 169 (2021)
Poisoning with organophosphorus compounds used as pesticides or misused as chemical weapons remains a serious threat to human health and life. Their toxic effects result from irreversible blockade of the enzymes acetylcholinesterase and butyrylcholin
Externí odkaz:
https://doaj.org/article/14ec8548063b41f1b2435717dd3df135
Autor:
Jakub Jończyk, Justyna Godyń, Ewelina Stawarska, Beata Morak-Młodawska, Małgorzata Jeleń, Krystian Pluta, Barbara Malawska
Publikováno v:
Molecules, Vol 25, Iss 11, p 2604 (2020)
The inverse correlation observed between Alzheimer’s disease (AD) and cancer has prompted us to look for cholinesterase-inhibiting activity in phenothiazine derivatives that possess anticancer properties. With the use of in silico and in vitro scre
Externí odkaz:
https://doaj.org/article/1a61fca694ef43b1a61990b7f12842f8
Autor:
Kamila Czarnecka, Małgorzata Girek, Przemysław Wójtowicz, Paweł Kręcisz, Robert Skibiński, Jakub Jończyk, Kamil Łątka, Marek Bajda, Anna Walczak, Grzegorz Galita, Jacek Kabziński, Ireneusz Majsterek, Piotr Szymczyk, Paweł Szymański
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 11, p 3765 (2020)
A series of new tetrahydroacridine and 3,5-dichlorobenzoic acid hybrids with different spacers were designed, synthesized, and evaluated for their ability to inhibit both cholinesterase enzymes. Compounds 3a, 3b, 3f, and 3g exhibited selective butyry
Externí odkaz:
https://doaj.org/article/e31425d6c23c4996a96f2fb20d8acfc8
Publikováno v:
PLoS ONE, Vol 12, Iss 10, p e0186108 (2017)
The crucial role of G-protein coupled receptors and the significant achievements associated with a better understanding of the spatial structure of known receptors in this family encouraged us to undertake a study on the histamine H3 receptor, whose
Externí odkaz:
https://doaj.org/article/fe3e0b7763de41a9b7954e7d6b4eb25d
Autor:
Dariusz Timler, Oktawiusz Bończak, Jakub Jończyk, Petre Iltchev, Andrzej Śliwczyński, Michał Marczak
Publikováno v:
Annals of Agricultural and Environmental Medicine, Vol 21, Iss 872203, Pp 212-216 (2014)
Aim. To analyze tears in sterile surgical gloves used by surgeons in the operating theatre of the Trauma and Orthopedic Surgery Department, Copernicus Memorial Hospital, Łódź, Poland Materials and Method. This study analyzes tears in sterile surg
Externí odkaz:
https://doaj.org/article/b0155adab54c4c24a483fe4dc4fe0c90