Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Jakub Jakowiecki"'
Publikováno v:
Biomolecules, Vol 11, Iss 7, p 935 (2021)
Alzheimer’s disease is the most common progressive neurodegenerative disorder and is characterized by the presence of amyloid β (Aβ) plaques in the brain. The γ-secretase complex, which produces Aβ, is an intramembrane-cleaving protease consist
Externí odkaz:
https://doaj.org/article/c3bf7f0914384f1b920ce64ce9a2807a
Autor:
Jakub Jakowiecki, Renata Abel, Urszula Orzeł, Paweł Pasznik, Robert Preissner, Sławomir Filipek
Publikováno v:
Molecules, Vol 26, Iss 9, p 2456 (2021)
The CB1 cannabinoid receptor (CB1R) contains one of the longest N termini among class A G protein-coupled receptors. Mutagenesis studies suggest that the allosteric binding site of cannabidiol (CBD) involves residues from the N terminal domain. In or
Externí odkaz:
https://doaj.org/article/007d1f4d20d541678928de7c3bdebe39
Publikováno v:
Molecules, Vol 25, Iss 8, p 1930 (2020)
Most G protein-coupled receptors that bind the hydrophobic ligands (lipid receptors and steroid receptors) belong to the most populated class A (rhodopsin-like) of these receptors. Typical examples of lipid receptors are: rhodopsin, cannabinoid (CB),
Externí odkaz:
https://doaj.org/article/ff05edf6023c42ac9e64c0e9415b8d76
Autor:
Urszula Orzeł, Paweł Pasznik, Przemysław Miszta, Marcin Lorkowski, Szymon Niewieczerzał, Jakub Jakowiecki, Sławomir Filipek
Publikováno v:
Nucleic Acids Research.
Despite recent advances in research, the mechanism of Alzheimer's disease is not fully understood yet. Understanding the process of cleavage and then trimming of peptide substrates, can help selectively block γ-secretase (GS) to stop overproduction
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ebfe99ada7a62471a4591b7dab49b8cb
https://doi.org/10.1093/nar/gkad409
https://doi.org/10.1093/nar/gkad409
Publikováno v:
Methods in Molecular Biology ISBN: 9781071629734
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6d4c1844b45d719c2aa18c2df8817aa7
https://doi.org/10.1007/978-1-0716-2974-1_19
https://doi.org/10.1007/978-1-0716-2974-1_19
Autor:
Robert Preissner, Slawomir Filipek, Jakub Jakowiecki, Urszula Orzeł, Pawel Pasznik, Renata Abel
Publikováno v:
Molecules, Vol 26, Iss 2456, p 2456 (2021)
Molecules
Volume 26
Issue 9
Molecules
Volume 26
Issue 9
The CB1 cannabinoid receptor (CB1R) contains one of the longest N termini among class A G protein-coupled receptors. Mutagenesis studies suggest that the allosteric binding site of cannabidiol (CBD) involves residues from the N terminal domain. In or
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb09c905a0214e3a49ef4d73eed03e3b
https://www.mdpi.com/1420-3049/26/9/2456
https://www.mdpi.com/1420-3049/26/9/2456
Autor:
Waseem Imtiaz Ahmad, Demet Araç, Patricio Atanes, Bellinda Benhamú, Apurba Bhattarai, Célia A. Bouazza, Robert Cerchio, Steven J. Charlton, Amitabha Chattopadhyay, Suzie Chen, Arnau Cordomí, George R. Dubyak, Frederick J. Ehlert, Treyton S. Farnan, Sławomir Filipek, Rafael Franco, Karolina Gherbi, Javier González-Maeso, Nickolaj J. Groenewoud, Thais Rafael Guimarães, Xu Han, Terence E. Hébert, Nicholas D. Holliday, Jakub Jakowiecki, Beata Jastrzebska, Karen Priyadarshini John, Sadashiva S. Karnik, Peter Keov, Amanuel Kibrom, Elizabeth A. Knauss, Irina Kufareva, G. Aditya Kumar, Steven La Plante, Sacha Thierry Larda, Katherine Leon, Jing Li, María L. López-Rodríguez, Ryan D. Martin, Yinglong Miao, Przemysław Miszta, Madhura Mohole, Gemma Navarro, Tony Ngo, Marvin T. Nieman, Szymon Niewieczerzał, Joseph T. Ortega, Aditya Pandey, Leonardo Pardo, Paul S.-H. Park, Shanta J. Persaud, Robert Scott Prosser, Xiangli Qu, Sudarshan Rajagopal, Kathy Sengmany, Durba Sengupta, Salvador Sierra, Khuraijam Dhanachandra Singh, Nicola J. Smith, Sean S. So, Amantha Thathiah, Rudy Toneatti, Henar Vázquez-Villa, Gayathri Viswanathan, David B. Wainscott, Jinan Wang, Dejian Wang, Francis S. Willard, Donna S. Woulfe, Beili Wu, Kevin Zheng
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::59703b19a2b7c1f802975ba0bbd6c816
https://doi.org/10.1016/b978-0-12-816228-6.01002-3
https://doi.org/10.1016/b978-0-12-816228-6.01002-3
G protein-coupled receptors (GPCRs) are activated or modulated by a very large set of divergent ligands. The GPCR superfamily of cell surface receptors plays a key role in cellular signaling in the human body, being involved in nearly all physiologic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6d94c957ca306999ae3f8d75dd1c8b92
https://doi.org/10.1016/b978-0-12-816228-6.00003-9
https://doi.org/10.1016/b978-0-12-816228-6.00003-9
GPCRM: a homology modeling web service with triple membrane-fitted quality assessment of GPCR models
Autor:
Agnieszka Sztyler, Slawomir Filipek, Przemyslaw Miszta, Jakub Jakowiecki, Dorota Latek, Pawel Pasznik
Publikováno v:
Nucleic Acids Research
Due to the involvement of G protein-coupled receptors (GPCRs) in most of the physiological and pathological processes in humans they have been attracting a lot of attention from pharmaceutical industry as well as from scientific community. Therefore,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33ec165559c627a8f83c31dc98470387
https://doi.org/10.1093/nar/gky429
https://doi.org/10.1093/nar/gky429
Autor:
Jan Ludwiczak, Piotr Maj, Magdalena Dąbrowska, Piotr Wilk, Slawomir Filipek, Wojciech Rypniewski, A. Dowiercial, Wojciech Rode, Tomasz Frączyk, Joanna Cieśla, Katarzyna Banaszak, Agnieszka K. Bronowska, Adam Jarmuła, Jakub Jakowiecki
Publikováno v:
Journal of Molecular Graphics and Modelling. 77:33-50
Three crystal structures are presented of nematode thymidylate synthases (TS), including Caenorhabditis elegans (Ce) enzyme without ligands and its ternary complex with dUMP and Raltitrexed, and binary complex of Trichinella spiralis (Ts) enzyme with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cae87707a533ef676cb7f197641ed06
https://doi.org/10.1016/j.jmgm.2017.08.008
https://doi.org/10.1016/j.jmgm.2017.08.008