Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Jakub Hynšt"'
Autor:
Jakub Trizuljak, Paulína Likavcová, Kateřina Staňo Kozubík, Zuzana Vrzalová, Jakub Hynšt, Tereza Deissová, Jiří Štika, Lenka Radová, Marie Prudková, Jana Vaculová, Ivona Blaháková, Petr Smejkal, Jan Kamelander, Šárka Pospíšilová, Michael Doubek
Publikováno v:
Platelets, Vol 35, Iss 1 (2024)
Inherited thrombocytopenias (ITs) encompass a group of rare disorders characterized by diminished platelet count. Recent advancements have unveiled various forms of IT, with inherited thrombocytopenia 2 (THC2) emerging as a prevalent subtype associat
Externí odkaz:
https://doaj.org/article/fc05d1ef48eb442e9b39d2d47ebad9ef
Autor:
Anna Panovská, Hana Jelínková, Andrea Marečková, Šárka Pospíšilová, Michael Doubek, Veronika Navrkalová, Karol Pál, Jakub Hynšt, Karla Plevová, Šárka Pavlová, Andrea Janíková, Tomáš Reigl, Jana Kotašková, Zuzana Vrzalová, Kamila Stránská
Publikováno v:
The Journal of Molecular Diagnostics. 23:959-974
B-cell neoplasms represent a clinically heterogeneous group of hematologic malignancies with considerably diverse genomic architecture recently endorsed by next-generation sequencing (NGS) studies. Because multiple genetic defects have a potential or
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3c3f193c9f19fb0a0eaefd9054661519
https://doi.org/10.1016/j.jmoldx.2021.05.007
https://doi.org/10.1016/j.jmoldx.2021.05.007
Autor:
Šárka Pospíšilová, Hana Kubová, Petra Bencurova, Jiri Baloun, Milan Brázdil, Jakub Hynšt, Jan Oppelt
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Scientific Reports
Scientific Reports
Temporal lobe epilepsy (TLE) is the most common epilepsy type. TLE onset in infancy aggravates features like severity, drug responsiveness, or development of comorbidities. These aggravations may arise from altered micro RNA (miRNA) expression specif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e68177d873844982941b30580dd2d4dd
https://doaj.org/article/9db2b901db6249209f30744cba479bd3
https://doaj.org/article/9db2b901db6249209f30744cba479bd3
Autor:
Marcela Zenatova, Šárka Pospíšilová, Nikola Tom, Yvona Brychtová, Karla Plevová, Jitka Malčíková, Barbara Dvorackova, Šárka Pavlová, Jakub Hynšt, Jiri Mayer, Michael Doubek, Lenka Radová, Karol Pál, Boris Tichy, Kristyna Zavacka, Anna Panovská, Barbara Kunt Vonkova, Jana Kotašková, Eva Ondroušková
Publikováno v:
Blood
Patients with chronic lymphocytic leukemia (CLL) with TP53 mutations with a >10% variant allele frequency (VAF) are often refractory to chemotherapy and benefit from targeted therapy. Malcikova and colleagues correlated TP53 mutations with
Key P
Key P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9256fec657c01f658f2878cff713a6e
http://europepmc.org/articles/PMC8703362
http://europepmc.org/articles/PMC8703362
Autor:
Daniela Zackova, Zdenek Racil, Tomáš Jurček, Zdenka Herudkova, Martin Čulen, Jiri Mayer, Tomáš Loja, Lukas Stejskal, Marianna Romzova, Dagmar Smitalová, Jakub Hynšt, Nikola Tom
Publikováno v:
British journal of haematologyReferences. 194(3)
There is an emerging body of evidence that patients with chronic myeloid leukaemia (CML) may carry not only breakpoint cluster region-Abelson murine leukaemia viral oncogene homologue 1 (BCR-ABL1) kinase domain mutations (BCR-ABL1 KD mutations), but
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8345ada39b3024b03cc3d4a824bb4320
https://pubmed.ncbi.nlm.nih.gov/34212373
https://pubmed.ncbi.nlm.nih.gov/34212373
Publikováno v:
PeerJ, Vol 9, p e10897 (2021)
PeerJ
PeerJ
Molecular profiling of tumor samples has acquired importance in cancer research, but currently also plays an important role in the clinical management of cancer patients. Rapid identification of genomic aberrations improves diagnosis, prognosis and e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9678471d189951923a7b01ae183b52d1
https://doi.org/10.7717/peerj.10897
https://doi.org/10.7717/peerj.10897
Autor:
Veronika Mancikova, Michaela Pesova, Sarka Pavlova, Robert Helma, Kristyna Zavacka, Vaclav Hejret, Petr Taus, Jakub Hynst, Karla Plevova, Jitka Malcikova, Sarka Pospisilova
Publikováno v:
Molecular Oncology, Vol 17, Iss 1, Pp 82-97 (2023)
TP53 gene abnormalities represent the most important biomarker in chronic lymphocytic leukemia (CLL). Altered protein modifications could also influence p53 function, even in the wild‐type protein. We assessed the impact of p53 protein phosphorylat
Externí odkaz:
https://doaj.org/article/d23f7fd800de4b44a79aa2866eceb35e
Publikováno v:
PeerJ
PeerJ, Vol 7, p e7071 (2019)
PeerJ, Vol 7, p e7071 (2019)
Background Extensive genome rearrangements, known as chromothripsis, have been recently identified in several cancer types. Chromothripsis leads to complex structural variants (cSVs) causing aberrant gene expression and the formation of de novo fusio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26517faa1948987b1b29e8dc355720ab
https://doi.org/10.7717/peerj.7071
https://doi.org/10.7717/peerj.7071
Autor:
Petra Bencurova, Jiri Baloun, Jakub Hynst, Jan Oppelt, Hana Kubova, Sarka Pospisilova, Milan Brazdil
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract Temporal lobe epilepsy (TLE) is the most common epilepsy type. TLE onset in infancy aggravates features like severity, drug responsiveness, or development of comorbidities. These aggravations may arise from altered micro RNA (miRNA) expressi
Externí odkaz:
https://doaj.org/article/9db2b901db6249209f30744cba479bd3
Publikováno v:
PeerJ, Vol 7, p e7071 (2019)
Background Extensive genome rearrangements, known as chromothripsis, have been recently identified in several cancer types. Chromothripsis leads to complex structural variants (cSVs) causing aberrant gene expression and the formation of de novo fusio
Externí odkaz:
https://doaj.org/article/066305c8bc5144169287988ec546a725