Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Jakub Harnoš"'
Autor:
Kateřina Hanáková, Ondřej Bernatík, Marek Kravec, Miroslav Micka, Jitender Kumar, Jakub Harnoš, Petra Ovesná, Petra Paclíková, Matěj Rádsetoulal, David Potěšil, Konstantinos Tripsianes, Lukáš Čajánek, Zbyněk Zdráhal, Vítězslav Bryja
Publikováno v:
Cell Communication and Signaling, Vol 17, Iss 1, Pp 1-21 (2019)
Abstract Background Dishevelled (DVL) is an essential component of the Wnt signaling cascades. Function of DVL is controlled by phosphorylation but the molecular details are missing. DVL3 contains 131 serines and threonines whose phosphorylation gene
Externí odkaz:
https://doaj.org/article/59bcf25501ed4898813e2a7a806d2bac
Autor:
Jakub Harnoš, Maria Consuelo Alonso Cañizal, Miroslav Jurásek, Jitender Kumar, Cornelia Holler, Alexandra Schambony, Kateřina Hanáková, Ondřej Bernatík, Zbyněk Zdráhal, Kristína Gömöryová, Tomáš Gybeľ, Tomasz Witold Radaszkiewicz, Marek Kravec, Lukáš Trantírek, Jan Ryneš, Zankruti Dave, Ana Iris Fernández-Llamazares, Robert Vácha, Konstantinos Tripsianes, Carsten Hoffmann, Vítězslav Bryja
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-18 (2019)
Dishevelled (DVL) is the key component of Wnt signaling pathway that acts as a signaling hub. Here, authors study the conformational dynamics of DVL3 in vivo using their engineered FlAsH-based FRET biosensors and describe how Wnt activation opens DVL
Externí odkaz:
https://doaj.org/article/c656ec6d84244ea4ba47e39232d91995
Autor:
Karol Kaiser, Daniel Gyllborg, Jan Procházka, Alena Salašová, Petra Kompaníková, Francisco Lamus Molina, Rocio Laguna-Goya, Tomasz Radaszkiewicz, Jakub Harnoš, Michaela Procházková, David Potěšil, Roger A. Barker, Ángel Gato Casado, Zbyněk Zdráhal, Radislav Sedláček, Ernest Arenas, J. Carlos Villaescusa, Vítězslav Bryja
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
WNTs can signal over long distances but how this arises in the brain is unclear. Here, the authors show that WNT5A is secreted from the choroid plexus of the developing hindbrain (but not the telencephalon) and transported in the CSF with lipoprotein
Externí odkaz:
https://doaj.org/article/b5243ecd5bb74a85a22885abf4c818ed
Autor:
Katharina Seitz, Verena Dürsch, Jakub Harnoš, Vitezslav Bryja, Marc Gentzel, Alexandra Schambony
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e87132 (2014)
β-Catenin independent, non-canonical Wnt signaling pathways play a major role in the regulation of morphogenetic movements in vertebrates. The term non-canonical Wnt signaling comprises multiple, intracellularly divergent, Wnt-activated and β-Caten
Externí odkaz:
https://doaj.org/article/01757cc2e0e249979e3258fd9a6c6d28
Autor:
Vitezslav Bryja, Tomáš Gybel, Ranjani Sri Ganji, Jan Mulder, Jakub Harnoš, Jana Valnohova, Maria Kowalski-Jahn, Zbynek Zdrahal, Ondrej Bernatik, Cecilia Lindskog, Katerina Strakova, Vishnu M. Dhople, Gunnar Schulte
Publikováno v:
Journal of Biological Chemistry. 293:18477-18493
Frizzleds (FZDs) are receptors for secreted lipoglycoproteins of the Wingless/Int-1 (WNT) family, initiating an important signal transduction network in multicellular organisms. FZDs are G protein–coupled receptors (GPCRs), which are well known to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f07e2aceac2a4e8002ee3979f14b9a1f
https://doi.org/10.1074/jbc.ra118.004656
https://doi.org/10.1074/jbc.ra118.004656
Autor:
Petra Paclíková, Jakub Harnoš, Zbyněk Zdráhal, David Potěšil, Tomasz Witold Radaszkiewicz, Vítězslav Bryja
Publikováno v:
Cellular Signalling. 85:110058
Dishevelled (DVL) proteins are key mediators of most Wnt pathways. In all vertebrates, three DVL paralogs are present (DVL1, DVL2 and DVL3) but it is poorly defined to what extent they are functionally redundant. Here, we generated T-REx HEK 293 cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c49ccdfa87afe1cd5549b740a76a84e2
https://doi.org/10.1016/j.cellsig.2021.110058
https://doi.org/10.1016/j.cellsig.2021.110058
Autor:
Miroslav Micka, Matěj Rádsetoulal, Kateřina Hanáková, Petra Paclíková, Jakub Harnoš, Ondřej Bernatík, Petra Ovesná, Lukas Cajanek, Konstantinos Tripsianes, David Potěšil, Jitender Kumar, Zbyněk Zdráhal, Marek Kravec, Vítězslav Bryja
Publikováno v:
Cell Communication and Signaling : CCS
Cell Communication and Signaling, Vol 17, Iss 1, Pp 1-21 (2019)
Cell Communication and Signaling, Vol 17, Iss 1, Pp 1-21 (2019)
BackgroundDishevelled (DVL) is an essential component of the Wnt signaling cascades. Function of DVL is controlled by phosphorylation but the molecular details are missing. DVL3 contains 131 serines and threonines whose phosphorylation generates comp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0017372521a710f20157736618ecedae
https://doi.org/10.1186/s12964-019-0470-z
https://doi.org/10.1186/s12964-019-0470-z
Autor:
Anita Grund, Anne M. Merks, Annette Borchers, Jakub Harnoš, Sarah F. S. Becker, Vítězslav Bryja, Marie-Claire Kratzer, Jubin Kashef, Klaudia Giehl
Publikováno v:
Development (Cambridge, England). 147(10)
Directional migration during embryogenesis and tumor progression faces the challenge that numerous external signals need to converge to precisely control cell movement. The Rho guanine exchange factor (GEF) Trio is especially well suited to relay sig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0987676fefcc3ddcf05efba3b38dadda
https://pubmed.ncbi.nlm.nih.gov/32366678
https://pubmed.ncbi.nlm.nih.gov/32366678
Autor:
Alexandra Schambony, Tomasz Witold Radaszkiewicz, Maria Consuelo Alonso Cañizal, Robert Vácha, Jan Ryneš, Konstantinos Tripsianes, Jitender Kumar, Carsten Hoffmann, Zbyněk Zdráhal, Kateřina Hanáková, Zankruti Dave, Lukáš Trantírek, Miroslav Jurásek, Ana Iris Fernández-Llamazares, Jakub Harnoš, Marek Kravec, Cornelia Holler, Ondřej Bernatík, Vítězslav Bryja, Tomáš Gybeľ, Kristína Gömöryová
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-18 (2019)
Nature Communications
Nature Communications
Dishevelled (DVL) is the key component of the Wnt signaling pathway. Currently, DVL conformational dynamics under native conditions is unknown. To overcome this limitation, we develop the Fluorescein Arsenical Hairpin Binder- (FlAsH-) based FRET in v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5af2d2100c7aaed0c7ee83d894e2a39
https://doi.org/10.1038/s41467-019-09651-7
https://doi.org/10.1038/s41467-019-09651-7
Autor:
Zbyněk Zdráhal, J. Carlos Villaescusa, Rocio Laguna-Goya, Karol Kaiser, Francisco Lamus Molina, Vítězslav Bryja, Radislav Sedlacek, Daniel Gyllborg, Petra Kompanikova, Ernest Arenas, Ángel Gato Casado, Jakub Harnoš, Alena Salašová, Tomasz Witold Radaszkiewicz, David Potěšil, Michaela Prochazkova, Roger A. Barker, Jan Prochazka
Publikováno v:
Nature Communications
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Kaiser, K, Gyllborg, D, Procházka, J, Salašová, A, Kompaníková, P, Molina, F L, Laguna-Goya, R, Radaszkiewicz, T, Harnoš, J, Procházková, M, Potěšil, D, Barker, R A, Casado, Á G, Zdráhal, Z, Sedláček, R, Arenas, E, Villaescusa, J C & Bryja, V 2019, ' WNT5A is transported via lipoprotein particles in the cerebrospinal fluid to regulate hindbrain morphogenesis ', Nature Communications, vol. 10, no. 1, 1498 . https://doi.org/10.1038/s41467-019-09298-4
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Kaiser, K, Gyllborg, D, Procházka, J, Salašová, A, Kompaníková, P, Molina, F L, Laguna-Goya, R, Radaszkiewicz, T, Harnoš, J, Procházková, M, Potěšil, D, Barker, R A, Casado, Á G, Zdráhal, Z, Sedláček, R, Arenas, E, Villaescusa, J C & Bryja, V 2019, ' WNT5A is transported via lipoprotein particles in the cerebrospinal fluid to regulate hindbrain morphogenesis ', Nature Communications, vol. 10, no. 1, 1498 . https://doi.org/10.1038/s41467-019-09298-4
WNTs are lipid-modified proteins that control multiple functions in development and disease via short- and long-range signaling. However, it is unclear how these hydrophobic molecules spread over long distances in the mammalian brain. Here we show th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d8a03c1fdd2276e90d12c312ffda8f8
