Zobrazeno 1 - 10
of 100
pro vyhledávání: '"Jakub Godlewski"'
Publikováno v:
Frontiers in Neurology, Vol 15 (2024)
Birth asphyxia and its main sequel, hypoxic-ischemic encephalopathy, are one of the leading causes of children’s deaths worldwide and can potentially worsen the quality of life in subsequent years. Despite extensive research efforts, efficient ther
Externí odkaz:
https://doaj.org/article/9af50b3c0df44ddf94db5fee61a044fe
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 35, Iss 1, Pp 102141- (2024)
MicroRNA-128-3p (miR-128-3p) is a versatile molecule with multiple functions in the physiopathology of the human central nervous system. Perturbations of miR-128-3p, which is enriched in the brain, contribute to a plethora of neurodegenerative disord
Externí odkaz:
https://doaj.org/article/9f2f13a2570b4fa6b6156efa76f25e46
Publikováno v:
Cells, Vol 12, Iss 4, p 552 (2023)
The ever-increasing number of cancer cases and persistently high mortality underlines the urgent need to acquire new perspectives for developing innovative therapeutic approaches. As the research on protein-coding genes brought significant yet only i
Externí odkaz:
https://doaj.org/article/adc32c606d2c4954b0932fd7b60685ce
Autor:
Vivek Bhaskaran, Michal O. Nowicki, Mahmoud Idriss, Miguel A. Jimenez, Gianmarco Lugli, Josie L. Hayes, Ahmad Bakur Mahmoud, Rachel E. Zane, Carmela Passaro, Keith L. Ligon, Daphne Haas-Kogan, Agnieszka Bronisz, Jakub Godlewski, Sean E. Lawler, E. Antonio Chiocca, Pierpaolo Peruzzi
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
The delivery of single therapeutic microRNAs in brain cancers is challenging. Here, the authors engineer three neuronal microRNAs (miR-124, 128 and 137) into a cluster that, targeting oncogenic chromatin repressors, increases survival of GBM-bearing
Externí odkaz:
https://doaj.org/article/9eb6fe5b852d43329fafc6511460a696
Publikováno v:
Antioxidants, Vol 10, Iss 11, p 1775 (2021)
The over-activation of NMDA receptors and oxidative stress are important components of neonatal hypoxia–ischemia (HI). Kynurenic acid (KYNA) acts as an NMDA receptor antagonist and is known as a reactive oxygen species (ROS) scavenger, which makes
Externí odkaz:
https://doaj.org/article/93a58beeddcc4ebeb74d1e4501a38547
Autor:
Jakub Godlewski, Ruben Ferrer-Luna, Arun K. Rooj, Marco Mineo, Franz Ricklefs, Yuji S. Takeda, M. Oskar Nowicki, Elżbieta Salińska, Ichiro Nakano, Hakho Lee, Ralph Weissleder, Rameen Beroukhim, E. Antonio Chiocca, Agnieszka Bronisz
Publikováno v:
Stem Cell Reports, Vol 8, Iss 6, Pp 1497-1505 (2017)
Despite the importance of molecular subtype classification of glioblastoma (GBM), the extent of extracellular vesicle (EV)-driven molecular and phenotypic reprogramming remains poorly understood. To reveal complex subpopulation dynamics within the he
Externí odkaz:
https://doaj.org/article/6a981b2fa5054d1bbf381dcaaae8eaed
MicroRNA-Mediated Dynamic Bidirectional Shift between the Subclasses of Glioblastoma Stem-like Cells
Autor:
Arun K. Rooj, Franz Ricklefs, Marco Mineo, Ichiro Nakano, E. Antonio Chiocca, Agnieszka Bronisz, Jakub Godlewski
Publikováno v:
Cell Reports, Vol 19, Iss 10, Pp 2026-2032 (2017)
Large-scale transcriptomic profiling of glioblastoma (GBM) into subtypes has provided remarkable insight into the pathobiology and heterogeneous nature of this disease. The mechanisms of speciation and inter-subtype transitions of these molecular sub
Externí odkaz:
https://doaj.org/article/ac691689f0e54125977baa005e86d372
Autor:
Marco Mineo, Franz Ricklefs, Arun K. Rooj, Shawn M. Lyons, Pavel Ivanov, Khairul I. Ansari, Ichiro Nakano, E. Antonio Chiocca, Jakub Godlewski, Agnieszka Bronisz
Publikováno v:
Cell Reports, Vol 15, Iss 11, Pp 2500-2509 (2016)
Long non-coding RNAs (lncRNAs) have an undefined role in the pathobiology of glioblastoma multiforme (GBM). These tumors are genetically and phenotypically heterogeneous with transcriptome subtype-specific GBM stem-like cells (GSCs) that adapt to the
Externí odkaz:
https://doaj.org/article/0acd0d2cd2a648f98bc5c0f9809c6463
Autor:
Nadiya M Teplyuk, Erik J Uhlmann, Galina Gabriely, Natalia Volfovsky, Yang Wang, Jian Teng, Priya Karmali, Eric Marcusson, Merlene Peter, Athul Mohan, Yevgenya Kraytsberg, Ron Cialic, E Antonio Chiocca, Jakub Godlewski, Bakhos Tannous, Anna M Krichevsky
Publikováno v:
EMBO Molecular Medicine, Vol 8, Iss 3, Pp 268-287 (2016)
Abstract MicroRNA‐10b (miR‐10b) is a unique oncogenic miRNA that is highly expressed in all GBM subtypes, while absent in normal neuroglial cells of the brain. miR‐10b inhibition strongly impairs proliferation and survival of cultured glioma ce
Externí odkaz:
https://doaj.org/article/e9a994ded85145f4bc720b5d9c37ec68
Publikováno v:
Antioxidants, Vol 9, Iss 8, p 747 (2020)
Rapid growth of brain tumors such as glioblastoma often results in oxygen deprivation and the emergence of hypoxic zones. In consequence, the enrichment of reactive oxygen species occurs, harming nonmalignant cells and leading them toward apoptotic c
Externí odkaz:
https://doaj.org/article/4bb491844afa403bb0b5893126a16f4b