Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Jakub Gemperle"'
Autor:
Lenka Koudelková, Markéta Pelantová, Zuzana Brůhová, Martin Sztacho, Vojtěch Pavlík, Dalibor Pánek, Jakub Gemperle, Pavel Talacko, Jan Brábek, Daniel Rösel
Publikováno v:
eLife, Vol 12 (2023)
The activation of Src kinase in cells is strictly controlled by intramolecular inhibitory interactions mediated by SH3 and SH2 domains. They impose structural constraints on the kinase domain holding it in a catalytically non-permissive state. The tr
Externí odkaz:
https://doaj.org/article/3b1c7c87d3bb4e7db96521db2ea11862
Publikováno v:
eLife, Vol 11 (2022)
CRISPR technology has made generation of gene knock-outs widely achievable in cells. However, once inactivated, their re-activation remains difficult, especially in diploid cells. Here, we present DExCon (Doxycycline-mediated endogenous gene Expressi
Externí odkaz:
https://doaj.org/article/0e55ab7449604c44903c7cabfb81df3a
Publikováno v:
Biology and Life Sciences Forum, Vol 21, Iss 1, p 29 (2023)
Endocytic recycling controls the return of internalised cargos to the plasma membrane to coordinate their positioning, availability and downstream signalling. The Rab4 and Rab11 small GTPase families regulate distinct recycling routes, broadly classi
Externí odkaz:
https://doaj.org/article/34a4c9de6bfe41e183ae5ac8eb8f7349
Publikováno v:
Molecular Oncology, Vol 13, Iss 2, Pp 264-289 (2019)
Protein p130Cas constitutes an adaptor protein mainly involved in integrin signaling downstream of Src kinase. Owing to its modular structure, p130Cas acts as a general regulator of cancer cell growth and invasiveness induced by different oncogenes.
Externí odkaz:
https://doaj.org/article/a8150fc97bc04d568eba1811cd1a86f5
Autor:
Jakub Gemperle, Rozálie Hexnerová, Martin Lepšík, Petr Tesina, Michal Dibus, Marian Novotný, Jan Brábek, Václav Veverka, Daniel Rosel
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-18 (2017)
Abstract CAS is a docking protein downstream of the proto-oncogene Src with a role in invasion and metastasis of cancer cells. The CAS SH3 domain is indispensable for CAS-mediated signaling, but structural aspects of CAS SH3 ligand binding and regula
Externí odkaz:
https://doaj.org/article/9f3efa9a9d654d38ab0c7c109782bb44
Autor:
Beverley Wilson, Chloe Flett, Jakub Gemperle, Craig Lawless, Matthew Hartshorn, Eleanor Hinde, Tess Harrison, Megan Chastney, Sarah Taylor, Jennifer Allen, Jim C. Norman, Thomas Zacharchenko, Patrick Caswell
Publikováno v:
Journal of Cell Science.
Endocytic recycling controls the return of internalised cargos to the plasma membrane to coordinate their positioning, availability and downstream signalling. The Rab4 and Rab11 small GTPase families regulate distinct recycling routes, broadly classi
Autor:
Lenka Koudelková, Zuzana Brůhová, Martin Sztacho, Vojtěch Pavlík, Dalibor Pánek, Jakub Gemperle, Jan Brábek, Daniel Rösel
The activation of Src kinase in cells is strictly controlled by intramolecular inhibitory interactions mediated by SH3 and SH2 domains. They impose structural constraints on the kinase domain holding it in a catalytically non-permissive state. The tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8307b96f9c387523d586edb3269e8be4
https://doi.org/10.1101/2022.08.23.504940
https://doi.org/10.1101/2022.08.23.504940
Autor:
Patrick Caswell, Jennifer Allen, Sarah Taylor, Megan Chastney, Thomas Harrison, Eleanor Hinde, Matthew Hartshorn, Chloe Flett, Craig Lawless, Jakub Gemperle, Beverley Wilson
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d8a0d88e11231c6d054f2bda86355f49
https://doi.org/10.15252/rc.2022767068
https://doi.org/10.15252/rc.2022767068
Publikováno v:
University of Manchester-PURE
bioRxiv
bioRxiv (the preprint server for biology)
bioRxiv
bioRxiv (the preprint server for biology)
CRISPR technology has made generation of gene knockouts widely achievable in cells. However, once inactivated, their reactivation remains difficult, especially in diploid cells. Here, we present DExCon (Doxycycline-mediated endogenous gene Expression
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d760f1394cb61bf3f581402d898abf3
https://doi.org/10.1101/2021.12.03.471086
https://doi.org/10.1101/2021.12.03.471086