Zobrazeno 1 - 10
of 57
pro vyhledávání: '"Jakub Kaminský"'
Autor:
Pavlo Potalitsyn, Lucie Mrázková, Irena Selicharová, Michaela Tencerová, Michaela Ferenčáková, Martina Chrudinová, Tereza Turnovská, Andrzej Marek Brzozowski, Aleš Marek, Jakub Kaminský, Jiří Jiráček, Lenka Žáková
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-15 (2023)
Abstract Insulin-like Growth Factor-2 (IGF2) is important for the regulation of human embryonic growth and development, and for adults’ physiology. Incorrect processing of the IGF2 precursor, pro-IGF2(156), leads to the formation of two IGF2 profor
Externí odkaz:
https://doaj.org/article/a75353d92d0a4e7788613a21e0db85e9
Autor:
Jan Jirát, Jan Rohlíček, Jakub Kaminský, Tomáš Jirkal, Luděk Ridvan, Eliška Skořepová, Vít Zvoníček, Michal Dušek, Miroslav Šoóš
Publikováno v:
IUCrJ, Vol 10, Iss 2, Pp 210-219 (2023)
The transformation processes of non-solvated ibrutinib into a series of halogenated benzene solvates are explored in detail here. The transformation was studied in real time by X-ray powder diffraction in a glass capillary. Crystal structures of chlo
Externí odkaz:
https://doaj.org/article/043c446e1ced43629bfa9c1f839c4b63
Publikováno v:
PLoS Computational Biology, Vol 18, Iss 1, p e1009678 (2022)
Sugars are crucial components in biosystems and industrial applications. In aqueous environments, the natural state of short saccharides or charged glycosaminoglycans is floating and wiggling in solution. Therefore, tools to characterize their struct
Externí odkaz:
https://doaj.org/article/bf6f22c832d94721b3166c1f7c64ac17
Publikováno v:
Molecules, Vol 27, Iss 23, p 8230 (2022)
The quality of theoretical NMR shieldings calculated at the quantum-chemical level depends on various theoretical aspects, of which the basis set type and size are among the most important factors. Nevertheless, not much information is available on t
Externí odkaz:
https://doaj.org/article/e97a72dfa4e24a14973ed33f0398994c
Publikováno v:
Journal of Chemical Theory and Computation. 18:4373-4386
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1f11e4c9e3447e51ee28c91e4042f06d
https://doi.org/10.1021/acs.jctc.2c00127
https://doi.org/10.1021/acs.jctc.2c00127
Autor:
Jingjing Lin, Seiya Asai, Irena Selicharová, Katarína Mitrová, Jakub Kaminský, Elinor Young, Jiří Jiráček
Publikováno v:
International Journal of Peptide Research and Therapeutics. 29
Insulin-like growth factor 1 (IGF-1) and its IGF-1 receptor (IGF-1R) belong to an important biological system that is involved in the regulation of normal growth, but that has also been recognized as playing a role in cancer. IGF-1R antagonists could
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::45d95ae8e18cccc074e175d37f2f27c9
https://doi.org/10.1007/s10989-023-10499-1
https://doi.org/10.1007/s10989-023-10499-1
Publikováno v:
Organic & Biomolecular Chemistry. 20:7613-7621
Modification of the carbohydrate scaffold is an important theme in drug and vaccine discovery. Therefore, the preparation of novel types of glycomimetics is of interest in synthetic carbohydrate chemistry. In this manuscript, we present an early inve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9dd648a9def02b2766ce3b7922ce5d4
https://doi.org/10.1039/d2ob01161a
https://doi.org/10.1039/d2ob01161a
Autor:
Tereza Hubáčková, Jan Kubelka, Jakub Kaminský, Nina Biačková, Františka Horáčková, Ondřej Socha
Publikováno v:
The Journal of Physical Chemistry B. 125:11350-11363
Lactic and malic acids are key substances in a number of biochemical processes in living cells and are also utilized in industry. Vibrational spectroscopy represents an efficient and sensitive way to study their structure and interactions. Since wate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3cf4e888fe3c99d7e8ee2b56d6f98350
https://doi.org/10.1021/acs.jpcb.1c05480
https://doi.org/10.1021/acs.jpcb.1c05480
Publikováno v:
Journal of chemical theory and computation. 18(7)
Determining the structure of saccharides in their native environment is crucial to understanding their function and more accurately targeting their utilization. Nuclear magnetic resonance observables such as the nuclear Overhauser effect or spin-spin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ed8036c669814595155fa36e0b5e6147
https://pubmed.ncbi.nlm.nih.gov/35687789
https://pubmed.ncbi.nlm.nih.gov/35687789
Autor:
Marta Lubos, Lucie Mrázková, Petra Gwozdiaková, Jan Pícha, Miloš Buděšínský, Jiří Jiráček, Jakub Kaminský, Lenka Žáková
Publikováno v:
Organicbiomolecular chemistry. 20(12)
Preptin is a 34-amino-acid-long peptide derived from the E-domain of a precursor of insulin-like growth factor 2 (pro-IGF2) with bone-anabolic and insulin secretion amplifying properties. Here, we describe the synthesis, structures, and biological ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cc8f83707e56f145314b9ae65af2030
https://pubmed.ncbi.nlm.nih.gov/35253830
https://pubmed.ncbi.nlm.nih.gov/35253830