Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Jakub Švenda"'
Autor:
Dominik Madea, Taufiqueahmed Mujawar, Aleš Dvořák, Kateřina Pospíšilová, Lucie Muchová, Petra Čubáková, Miroslav Kloz, Jakub Švenda, Libor Vítek, Petr Klán
Publikováno v:
The Journal of Organic Chemistry. 87:3089-3103
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f35d475b0bb044016046a3c6ce727bb9
https://doi.org/10.1021/acs.joc.1c02870
https://doi.org/10.1021/acs.joc.1c02870
Publikováno v:
The Journal of Organic Chemistry. 86:11845-11861
We report synthesis of two diastereomeric structures previously proposed for the complex secondary metabolite pseurotin A(2). Both structures were accessed from the same building blocks taking advantage of a stereodivergent nickel(II)-iamine-catalyze
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7cf971a7994f914690f63f7b048ba4c2
https://doi.org/10.1021/acs.joc.1c01152
https://doi.org/10.1021/acs.joc.1c01152
Autor:
Paweł M. Szczepanik, Andrey A. Mikhaylov, Ondřej Hylse, Roman Kučera, Petra Daďová, Marek Nečas, Lukáš Kubala, Kamil Paruch, Jakub Švenda
Publikováno v:
Angewandte Chemie (International ed. in English). 62(1)
We report a new synthetic strategy for the flexible preparation of forskolin-like molecules. The approach is different from the previously published works and employs a convergent assembly of the tricyclic labdane-type core from pre-functionalized cy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8fd33816b71a5bc8ec0523e9ddc8460
https://pubmed.ncbi.nlm.nih.gov/36321750
https://pubmed.ncbi.nlm.nih.gov/36321750
Autor:
Petr Slavíček, Jakub Švenda, Jiří Janoš, Sadegh Mahvidi, Petr Klán, Jiří Suchan, Dominik Madea, Taufiqueahmed Pirsaheb Mujawar
Publikováno v:
The Journal of Physical Chemistry A. 124:10457-10471
The photochemistry of bilirubin has been extensively studied due to its importance in the phototherapy of hyperbilirubinemia. In the present work, we investigated the ultrafast photodynamics of a bilirubin dipyrrinone subunit, vinylneoxanthobilirubic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::480f629e272640253f4afcb01b7bc346
https://doi.org/10.1021/acs.jpca.0c08945
https://doi.org/10.1021/acs.jpca.0c08945
Autor:
Dominik, Madea, Taufiqueahmed, Mujawar, Aleš, Dvořák, Kateřina, Pospíšilová, Lucie, Muchová, Petra, Čubáková, Miroslav, Kloz, Jakub, Švenda, Libor, Vítek, Petr, Klán
Publikováno v:
The Journal of organic chemistry. 87(5)
Bilirubin (BR) is an essential metabolite formed by the catabolism of heme. Phototherapy with blue-green light can be applied to reduce high concentrations of BR in blood and is used especially in the neonatal period. In this work, we studied the pho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::55bdf66ad1393bfded6d534650f9c018
https://pubmed.ncbi.nlm.nih.gov/35130431
https://pubmed.ncbi.nlm.nih.gov/35130431
Autor:
Prabhakara R. Tharra, Andrey A. Mikhaylov, Jiří Švejkar, Marina Gysin, Sven N. Hobbie, Jakub Švenda
Publikováno v:
Angewandte Chemie (International ed. in English). 61(17)
We report a concise synthesis of the naturally occurring protein synthesis inhibitor (+)-actinobolin (1). The densely functionalized and stereochemically complex molecular structure of 1 was assembled from (-)-quinic acid, L-threonine, and L-alanine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21dece570054e402b57c9bc1f287025f
https://pubmed.ncbi.nlm.nih.gov/35167723
https://pubmed.ncbi.nlm.nih.gov/35167723
Publikováno v:
The Journal of organic chemistry. 86(17)
We report synthesis of two diastereomeric structures previously proposed for the complex secondary metabolite pseurotin A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::affe3bb662a41432a8a70f95d3999ea8
https://pubmed.ncbi.nlm.nih.gov/34378926
https://pubmed.ncbi.nlm.nih.gov/34378926
Autor:
Lucie Muchová, Jiří Janoš, Petr Slavíček, Libor Vítek, Dominik Madea, Jakub Švenda, David Chalupa, Sadegh Mahvidi, Petr Klán, Aleš Dvořák, Taufiqueahmed Pirsaheb Mujawar
Publikováno v:
The Journal of organic chemistry. 85(20)
Phototherapy is a standard treatment for severe neonatal jaundice to remove toxic bilirubin from the blood. Here, the wavelength-dependent photochemistry of vinylneoxanthobilirubic acid methyl ester, a simplified model of a bilirubin dipyrrinone subu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93d46344edfaf9465ba10556b573b9c0
https://pubmed.ncbi.nlm.nih.gov/33003699
https://pubmed.ncbi.nlm.nih.gov/33003699
Autor:
Judit E. Šponer, Dimitri Shcherbakov, Erik C. Böttger, Lucyna Michalska, Jakub Švenda, Jiří Šponer, Petra Vojáčková, Marek Nečas
Publikováno v:
Journal of the American Chemical Society. 142(16)
A stereoselective synthesis of the ribosome-binding antitumor antibiotic (-)-bactobolin A is reported. The presented approach makes effective use of (-)-quinic acid as a chiral pool starting material and substrate stereocontrol to establish the five
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3f2bd2f956c2e12c8caff0710e6330a
https://pubmed.ncbi.nlm.nih.gov/32285674
https://pubmed.ncbi.nlm.nih.gov/32285674
Autor:
Ondřej Hylse, Jakub Švenda, Tomas Perecko, Aneta Svobodová, Roman Kučera, Kamil Paruch, Lukáš Kubala, Lukáš Maier
Publikováno v:
Angewandte Chemie International Edition. 56:12586-12589
A 24-step synthesis of (±)-forskolin is presented, which delivered hundred milligram quantities of this complex diterpene in one pass. Transformations key to our approach include: a) a strategic allylic transposition, b) stepwise assembly of a steri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::841b098ffb21a7a047beedf846e7c52c
https://doi.org/10.1002/anie.201706809
https://doi.org/10.1002/anie.201706809