Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Jakub Šinský"'
Publikováno v:
Molecules, Vol 25, Iss 4, p 874 (2020)
Delivery of therapeutic agents into the brain is a major challenge in central nervous system drug development. The blood−brain barrier (BBB) prevents access of biotherapeutics to their targets in the central nervous system and, therefore, prohibits
Externí odkaz:
https://doaj.org/article/1fe4a38e64564cd5a6333670e566c2aa
Autor:
Dominika Olešová, Dana Dobešová, Petra Majerová, Radana Brumarová, Aleš Kvasnička, Štěpán Kouřil, Eva Stevens, Jozef Hanes, Ľubica Fialová, Alena Michalicová, Juraj Piešťanský, Jakub Šinský, Petr Kaňovský, David Friedecký, Andrej Kováč
Publikováno v:
Journal of Neuroinflammation, Vol 21, Iss 1, Pp 1-25 (2024)
Abstract Background Accumulation of tau leads to neuroinflammation and neuronal cell death in tauopathies, including Alzheimer’s disease. As the disease progresses, there is a decline in brain energy metabolism. However, the role of tau protein in
Externí odkaz:
https://doaj.org/article/4004cf4093e94f4d9b7e89e99d742211
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 17, p 9207 (2021)
Tau protein plays a critical role in the assembly, stabilization, and modulation of microtubules, which are important for the normal function of neurons and the brain. In diseased conditions, several pathological modifications of tau protein manifest
Externí odkaz:
https://doaj.org/article/c9864ab268f441fbbd78d9702694e916