Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Jakub, Gunera"'
Autor:
Timo Heinrich, Carl Peterson, Richard Schneider, Sakshi Garg, Daniel Schwarz, Jakub Gunera, Anita Seshire, Lisa Kötzner, Sarah Schlesiger, Djordje Musil, Heike Schilke, Benjamin Doerfel, Patrizia Diehl, Pia Böpple, Ana R. Lemos, Pedro M. F. Sousa, Filipe Freire, Tiago M. Bandeiras, Emma Carswell, Nicholas Pearson, Sameer Sirohi, Mollie Hooker, Elisabeth Trivier, Rebecca Broome, Alexander Balsiger, Abigail Crowden, Christian Dillon, Dirk Wienke
Publikováno v:
Journal of Medicinal Chemistry. 65:9206-9229
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e22c0126effbafdbcab44017975b2c5d
https://doi.org/10.1021/acs.jmedchem.2c00403
https://doi.org/10.1021/acs.jmedchem.2c00403
Autor:
Timo, Heinrich, Carl, Peterson, Richard, Schneider, Sakshi, Garg, Daniel, Schwarz, Jakub, Gunera, Anita, Seshire, Lisa, Kötzner, Sarah, Schlesiger, Djordje, Musil, Heike, Schilke, Benjamin, Doerfel, Patrizia, Diehl, Pia, Böpple, Ana R, Lemos, Pedro M F, Sousa, Filipe, Freire, Tiago M, Bandeiras, Emma, Carswell, Nicholas, Pearson, Sameer, Sirohi, Mollie, Hooker, Elisabeth, Trivier, Rebecca, Broome, Alexander, Balsiger, Abigail, Crowden, Christian, Dillon, Dirk, Wienke
Publikováno v:
Journal of medicinal chemistry. 65(13)
The dysregulated Hippo pathway and, consequently, hyperactivity of the transcriptional YAP/TAZ-TEAD complexes is associated with diseases such as cancer. Prevention of YAP/TAZ-TEAD triggered gene transcription is an attractive strategy for therapeuti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8f113375d5ab1fa46e3e2aecd3136fe8
https://pubmed.ncbi.nlm.nih.gov/35763499
https://pubmed.ncbi.nlm.nih.gov/35763499
Autor:
Jeyaprakashnarayanan Seenisamy, Frank Becker, Djordje Musil, Jörg Bomke, Jakub Gunera, Uwe Eckert, Timo Heinrich, Felix Rohdich, Kerrin Hansen, Beatrix Blume, Christian Siegl, Frank Zenke, Jens Pfalzgraf, Dieter Spuck, Ansgar Wegener, Birgitta Leuthner, Melanie Dietz, Manja Friese-Hamim
Publikováno v:
Journal of Medicinal Chemistry. 62:11119-11134
The recently disclosed next generation of reversible, selective, and potent MetAP-2 inhibitors introduced a cyclic tartronic diamide scaffold. However, the lead compound 1a suffered from enterohepatic circulation, preventing further development. Neve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::539fb7d602f3d1bbfe1d4a86e7331eb7
https://doi.org/10.1021/acs.jmedchem.9b01070
https://doi.org/10.1021/acs.jmedchem.9b01070
Publikováno v:
Journal of medicinal chemistry. 63(19)
The orexin receptors are peptide-sensing G protein-coupled receptors that are intimately linked with regulation of the sleep/wake cycle. We used a recently solved X-ray structure of the orexin receptor subtype 2 in computational docking calculations
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5065d3a1af9918cc2909bd2b48c8ed6c
https://pubmed.ncbi.nlm.nih.gov/32977721
https://pubmed.ncbi.nlm.nih.gov/32977721
Autor:
Dorothee Weikert, Peter Kolb, Peter Gmeiner, Harald Hübner, Christopher J. Langmead, Frank Kraus, Jakub Gunera, Daniel M. Rosenbaum, Jie Yin, Theresa Pröll, Jan Hellmann, Matthäus Drabek
Publikováno v:
Proc Natl Acad Sci U S A
Orexins are neuropeptides that activate the rhodopsin-like G protein-coupled receptors OX1R and OX2R. The orexin system plays an important role in the regulation of the sleep-wake cycle and the regulation of feeding and emotions. The nonselective ore
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1836323ed93ff337a8da4d68cb8d067d
https://pubmed.ncbi.nlm.nih.gov/32669442
https://pubmed.ncbi.nlm.nih.gov/32669442
Publikováno v:
ACS Medicinal Chemistry Letters. 8:481-485
The β2-adrenergic receptor (β2AR) is a G protein-coupled receptor (GPCR) and a well-explored target. Here, we report the discovery of 13 ligands, ten of which are novel, of this particular GPCR. They have been identified by similarity- and substruc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ffd39dd1db5605bfcb05ec93c0b092ee
https://doi.org/10.1021/acsmedchemlett.6b00363
https://doi.org/10.1021/acsmedchemlett.6b00363
Publikováno v:
Journal of Biological Chemistry. 292:4003-4021
Prenyltransferases of the dimethylallyltryptophan synthase (DMATS) superfamily catalyze the attachment of prenyl or prenyl-like moieties to diverse acceptor compounds. These acceptor molecules are generally aromatic in nature and mostly indole or ind
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b7c4fa750c7acd27ae558643806fc06
https://doi.org/10.1074/jbc.m116.759118
https://doi.org/10.1074/jbc.m116.759118
Autor:
Timo, Heinrich, Jeyaprakashnarayanan, Seenisamy, Frank, Becker, Beatrix, Blume, Jörg, Bomke, Melanie, Dietz, Uwe, Eckert, Manja, Friese-Hamim, Jakub, Gunera, Kerrin, Hansen, Birgitta, Leuthner, Djordje, Musil, Jens, Pfalzgraf, Felix, Rohdich, Christian, Siegl, Dieter, Spuck, Ansgar, Wegener, Frank T, Zenke
Publikováno v:
Journal of medicinal chemistry. 62(24)
The recently disclosed next generation of reversible, selective, and potent MetAP-2 inhibitors introduced a cyclic tartronic diamide scaffold. However, the lead compound
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2b4dcbfeb991a35c29e879c5251cd665
https://pubmed.ncbi.nlm.nih.gov/31725285
https://pubmed.ncbi.nlm.nih.gov/31725285
Publikováno v:
Advanced Synthesis & Catalysis. 357:975-986
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b6920fe9d86c7b17685adbad76e6cc39
https://doi.org/10.1002/adsc.201400958
https://doi.org/10.1002/adsc.201400958
Publikováno v:
ACS medicinal chemistry letters. 8(5)
The β
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::98f588f28c82e66cedb799a4704c6f2a
https://pubmed.ncbi.nlm.nih.gov/28523097
https://pubmed.ncbi.nlm.nih.gov/28523097