Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Jakobus van Unen"'
Autor:
Niels Heemskerk, Lilian Schimmel, Chantal Oort, Jos van Rijssel, Taofei Yin, Bin Ma, Jakobus van Unen, Bettina Pitter, Stephan Huveneers, Joachim Goedhart, Yi Wu, Eloi Montanez, Abigail Woodfin, Jaap D. van Buul
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-17 (2016)
Endothelial cells can support leukocyte extravasation without causing vascular leakage, but the exact mechanism underlying this process has not been fully elucidated. Here the authors show that it is regulated through actomyosin-based endothelial por
Externí odkaz:
https://doaj.org/article/6c3133e60cd84e1f9874b018a721bd0a
Autor:
Marieke Mastop, Nathalie R Reinhard, Cristiane R Zuconelli, Fenna Terwey, Theodorus W J Gadella, Jakobus van Unen, Merel J W Adjobo-Hermans, Joachim Goedhart
Publikováno v:
PLoS ONE, Vol 13, Iss 4, p e0195649 (2018)
[This corrects the article DOI: 10.1371/journal.pone.0193705.].
Externí odkaz:
https://doaj.org/article/0b005f688a0b4cbe86761776992737de
Autor:
Marieke Mastop, Nathalie R Reinhard, Cristiane R Zuconelli, Fenna Terwey, Theodorus W J Gadella, Jakobus van Unen, Merel J W Adjobo-Hermans, Joachim Goedhart
Publikováno v:
PLoS ONE, Vol 13, Iss 3, p e0193705 (2018)
Förster Resonance Energy Transfer (FRET) provides a way to directly observe the activation of heterotrimeric G-proteins by G-protein coupled receptors (GPCRs). To this end, FRET based biosensors are made, employing heterotrimeric G-protein subunits
Externí odkaz:
https://doaj.org/article/fb7f53712c4d43f2ba1afea9d76b4818
Autor:
Jakobus van Unen, Anette D Stumpf, Benedikt Schmid, Nathalie R Reinhard, Peter L Hordijk, Carsten Hoffmann, Theodorus W J Gadella, Joachim Goedhart
Publikováno v:
PLoS ONE, Vol 11, Iss 1, p e0146789 (2016)
G-protein coupled receptors (GPCRs) can activate a heterotrimeric G-protein complex with subsecond kinetics. Genetically encoded biosensors based on Förster resonance energy transfer (FRET) are ideally suited for the study of such fast signaling eve
Externí odkaz:
https://doaj.org/article/112c57089ccf4aa78c57144f016e1bfe
Autor:
Lennart Brandenburg, Philipp Mertins, Kiara Freitag, Jakobus van Unen, Vivian Nguyen, Celina Wortmann, Paul Markus Mueller, Oliver Popp, Trendelina Rrustemi, Oliver Rocks, Lisa Spatt, Brett Larsen, Juliane Rademacher, Tony Pawson, Richard D. Bagshaw, Patricia Pascual-Vargas, Rebecca L Eccles, Olivier Pertz, Maciej T. Czajkowski, Carolin Barth, Evangelia Petsalaki, Monika Tucholska, Robert William Welke, Sunqu Zhang, Philipp Trnka, Geraldine Mbamalu, Louise E Heinrich, Anne-Claude Gingras, Marta Sanchez-Castro, Karen Colwill, Frederick P. Roth, Girolamo Giudice, Keziban M. Alp, Chris Bakal
Publikováno v:
Nature Cell Biology. 22:498-511
Rho GTPases are central regulators of the cytoskeleton and, in humans, are controlled by 145 multidomain guanine nucleotide exchange factors (RhoGEFs) and GTPase-activating proteins (RhoGAPs). How Rho signalling patterns are established in dynamic ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fc4598dba929d520edc41e8c6ebc87c3
https://doi.org/10.1038/s41556-020-0488-x
https://doi.org/10.1038/s41556-020-0488-x
Autor:
Joachim Goedhart, Jakobus van Unen
Publikováno v:
Small GTPases
Much of our current knowledge of Rho GTPase networks and the regulation by Rho guanine exchange factors (Rho GEFs) and Rho GTPase activating proteins (Rho GAPs) is based on population-based techniques. Over the last decades, technologies that enable
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2eab011b29db04c43b3aa6770628514
https://doi.org/10.1080/21541248.2017.1302551
https://doi.org/10.1080/21541248.2017.1302551
Autor:
Theodorus W. J. Gadella, Marten Postma, Joachim Goedhart, Eelco Hoogendoorn, Ali Rashidfarrokhi, Jakobus van Unen
Publikováno v:
Molecular Pharmacology, 90(3), 162-176. American Society for Pharmacology and Experimental Therapeutics
Genetically encoded biosensors based on Förster resonance energy transfer (FRET) can visualize responses of individual cells in real time. Here, we evaluated whether FRET-based biosensors provide sufficient contrast and specificity to measure activi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f457613db11f777c12afc44123ea0ed8
https://dare.uva.nl/personal/pure/en/publications/quantitative-singlecell-analysis-of-signaling-pathways-activated-immediately-downstream-of-histamine-receptor-subtypes(7bf567de-db2c-452d-829c-7a677dc04b5e).html
https://dare.uva.nl/personal/pure/en/publications/quantitative-singlecell-analysis-of-signaling-pathways-activated-immediately-downstream-of-histamine-receptor-subtypes(7bf567de-db2c-452d-829c-7a677dc04b5e).html
Autor:
Michel Bouvier, Merel J. W. Adjobo-Hermans, Joachim Goedhart, Jeanette Woolard, Jakobus van Unen, Carsten Hoffmann, Michael R. Bruchas, Ago Rinken, Stephen J. Hill
Publikováno v:
Molecular Pharmacology, 88, 589-95
Molecular Pharmacology, 88, 3, pp. 589-95
Molecular Pharmacology, 88(3), 589-595. American Society for Pharmacology and Experimental Therapeutics
Molecular Pharmacology, 88, 3, pp. 589-95
Molecular Pharmacology, 88(3), 589-595. American Society for Pharmacology and Experimental Therapeutics
Item does not contain fulltext The last frontier for a complete understanding of G-protein-coupled receptor (GPCR) biology is to be able to assess GPCR activity, interactions, and signaling in vivo, in real time within biologically intact systems. Th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2642076c04b30cb58711edc16a267aaf
https://doi.org/10.1124/mol.115.098897
https://doi.org/10.1124/mol.115.098897
Autor:
Nathalie R. Reinhard, Cristiane R. Zuconelli, Jakobus van Unen, Fenna Terwey, Joachim Goedhart, Marieke Mastop, Merel J. W. Adjobo-Hermans, Theodorus W. J. Gadella
Publikováno v:
PLoS ONE
PLoS One, 13, 3
PLoS ONE, 13(3):e0193705. Public Library of Science
PLoS ONE, Vol 13, Iss 3, p e0193705 (2018)
PLoS One, 13
PLoS One, 13, 3
PLoS ONE, 13(3):e0193705. Public Library of Science
PLoS ONE, Vol 13, Iss 3, p e0193705 (2018)
PLoS One, 13
Förster Resonance Energy Transfer (FRET) provides a way to directly observe the activation of heterotrimeric G-proteins by G-protein coupled receptors (GPCRs). To this end, FRET based biosensors are made, employing heterotrimeric G-protein subunits
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::989e1c0da9c58cc0c4727123a6fc228d
https://pubmed.ncbi.nlm.nih.gov/29617442
https://pubmed.ncbi.nlm.nih.gov/29617442
Autor:
Fenna Terwey, Nathalie R. Reinhard, Joachim Goedhart, Marieke Mastop, Theodorus W. J. Gadella, Cristiane R. Zuconelli, Jakobus van Unen, Merel J. W. Adjobo-Hermans
Förster Resonance Energy Transfer (FRET) provides a way to directly observe the activation of heterotrimeric G-proteins by G-protein coupled receptors (GPCRs). To this end, FRET based biosensors are made, employing heterotrimeric G-protein subunits
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::877a5460d91ce737766958f221374567
https://doi.org/10.1101/220632
https://doi.org/10.1101/220632
